solver 2,4,6-trimethylbenzenesulfonate | 78907-59-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: solver 2,4,6-trimethylbenzenesulfonate
• 英文别名: silver2,4,6-trimethylbenzenesulfonate；silver(I) mesitylsufonate；silver 2,4,6-trimethylbenzenesulfonate；Silver;2,4,6-trimethylbenzenesulfonate
• CAS: 78907-59-2
• 化学式: Ag*C₉H₁₁O₃S
• 分子量: 307.119
• InChiKey: HCQZNCVCVSEABN-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.51
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  65.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-bromo-4-methyl-2-pentanone 、 solver 2,4,6-trimethylbenzenesulfonate 以 乙腈 为溶剂， 反应 30.0h， 以66%的产率得到4-methyl-1-(2,4,6-trimethylbenzenesulfonyloxy)-2-pentanone
  参考文献：
  名称：

  降血脂药的研究。二。合成1-芳烃磺酰氧基-2-烷酮衍生物作为有效的酯酶抑制剂和降血脂药。

  摘要：

  合成了许多具有直链或支链不同长度烷基链的2-氧代烷基芳磺酸盐衍生物、2-氧代烷基双芳磺酸盐衍生物以及在烷基链的2-位具有缩酮部分的烷基芳磺酸盐衍生物，并评估了它们的酯酶抑制活性及降血脂活性。在这些化合物中，1-(2,4,6-三甲基苯磺酰氧基)-2-十二烷酮（III-1u）、1-(2,3,4,6-四甲基苯磺酰氧基)-2-己烷酮（III-1w）、-2-辛烷酮（III-1x）和-2-癸烷酮（III-1y）表现出强效的酯酶抑制活性（IC50分别为3×10-10、2×10-10、2×10-10和3×10-11M）。然而，相对于III和XII，具有烷基链上缩酮部分的磺酸盐（XV）和双磺酸盐（XVI）对酯酶的抑制活性较低。大多数化合物III和部分化合物XII表现出强效的降血脂活性，对应于体内超过50%的脂质降低效果（血浆甘油三酯和胆固醇酯）。讨论了这些化合物的构效关系。

  DOI：

  10.1248/cpb.34.3252
• 作为产物：
  描述：

  均三甲苯磺酸 、 silver nitrate 在 Na₂CO₃ 作用下， 以 水 为溶剂， 生成 solver 2,4,6-trimethylbenzenesulfonate
  参考文献：
  名称：

  Facile Synthesis of Effcient and Selective Ruthenium Olefin Metathesis Catalysts with Sulfonate and Phosphate Ligands

  摘要：

  A series of novel, air-stable ruthenium NHC catalysts with sulfonate and phosphate anions have been prepared easily in one pot at high yields using commercially available precursors. The catalysts were found to be effective for ring-opening metathesis polymerization, ring-closing metathesis, and cross-metathesis. The catalysts showed higher cis-selectivity in olefin cross-metathesis reactions as compared to earlier known ruthenium-based olefin metathesis catalysts, with allylbenzene and cis-1,4-diacetoxybutene as substrates.

  DOI：

  10.1021/om1007924

文献信息

• Studies of hypolipidemic agents. I. Syntheses and hypolipidemic activities of 1-substituted 2-alkanone derivatives.
  作者：KAZUO OGAWA、TADAFUMI TERADA、YOSHIYUKI MURANAKA、TOSHIHIRO HAMAKAWA、SADAO HASHIMOTO、SETSURO FUJII

  DOI：10.1248/cpb.34.1118

  日期：——

  Many 1-substituted 2-alkanone derivatives were synthesized and their inhibitory activities toward pancreatic lipase and esterase were examined in order to obtain hypolipidemic agents. 1-Benzenesulfonyloxy-2-pentanone (VI-2a) and 1-(2, 4, 6-trimethylbenzenesulfonyloxy)-2-pentanone (VI-2q) exhibited not only potent and selective esterase inhibitions (IC50 : 9.0×10-7M and 1.0×10-6M, respectively), but also potent hypolipidemic action (90 and 92% reductions of plasma triglyceride, and 53 and 90% reductions of plasma total cholesterol, respectively). A novel working hypothesis is presented to account for the lowering of the plasma lipids level, i.e., that inhibition of esterase and lipase activities in the small intestinal lumen may be responsible for the decrease in the plasma lipids level.

  合成了许多1-取代的2-酮烷基衍生物，并考察了它们对胰脂肪酶和酯酶的抑制活性，以期获得降脂药物。1-苯磺酰氧基-2-戊酮（VI-2a）和1-(2, 4, 6-三甲基苯磺酰氧基)-2-戊酮（VI-2q）不仅表现出显著且具有选择性的酯酶抑制（IC50：9.0×10^-7M 和 1.0×10^-6M），而且还具有强效的降脂作用（血浆甘油三脂分别减少90%和92%，血浆总胆固醇分别减少53%和90%）。提出了一个新的工作假设来解释血浆脂质水平的降低，即小肠腔内酯酶和脂肪酶活性的抑制可能是导致血浆脂质水平下降的原因。
• Building Stereoselectivity into a Chemoselective Ring-Opening Metathesis Polymerization Catalyst for Alternating Copolymerization
  作者：Sebastian Torker、Andre Müller、Peter Chen

  DOI：10.1002/anie.200906846

  日期：——

  This way and that: Ruthenium complexes with asymmetric bidentate phosphine ligands bearing two substituents that differ in size (green spheres) produce a totally alternating copolymer of norbornene and cyclooctene by ring‐opening metathesis polymerization (ROMP). The E/Z ratio can be influenced systematically by changing the bulkiness of the aryl sulfonate ligand (blue rectangles).

  这样的方式：具有不对称双齿膦配体的钌配合物带有两个大小不同的取代基（绿色球体），通过开环复分解聚合（ROMP）生成降冰片烯和环辛烯的完全交替的共聚物。的E / Z 比率可以系统通过改变芳基磺酸盐配位体（蓝色矩形）的体积的影响。
• Catalyst for olefin polymerization, process for the polymerization of
  申请人：Mitsui Petrochemical Industries, Ltd.

  公开号：US05412128A1

  公开（公告）日：1995-05-02

  The catalyst for olefin polymerization of the present invention contains R.sub.k.sup.1 R.sub.l.sup.2 R.sub.m.sup.3 M(SO.sub.3 R.sup.4) (M=Zr, Ti or Hf; R.sup.1-3 =a group having a cyclopentadienyl skeleton) as a catalyst component of a transition metal compound. According to the catalyst of the invention, an olefin polymer having excellent particle properties can be prepared with high polymerization activities, and further a copolymer having a narrow composition distribution can be prepared when two or more monomers are copolymerized. Of the above-mentioned transition metal compounds, a compound represented by the following formula is a novel compound unknown so far and shows excellent catalytic properties. ##STR1## (Cp=a group having a cyclopentadienyl skeleton, X=SO.sub.3 R, a halogen atom, R, OR, NR.sub.n, S(O).sub.q R, SiR.sub.3 or P (O).sub.q R.sub.3, n=1, 2 or 3; q=0, 1 or 2)

  本发明的烯烃聚合催化剂包含R.sub.k.sup.1 R.sub.l.sup.2 R.sub.m.sup.3 M(SO.sub.3 R.sup.4) (M=Zr、Ti或Hf；R.sup.1-3=具有环戊二烯基骨架的基团)作为过渡金属化合物的催化组分。根据本发明的催化剂，可以高聚合活性制备具有优异粒子性能的烯烃聚合物，进一步，在共聚合两种或更多单体时，可以制备具有窄分子量分布的共聚物。在上述过渡金属化合物中，以下式所表示的化合物是迄今为止未知的新化合物，且表现出优异的催化性能。##STR1## (Cp=具有环戊二烯基骨架的基团，X=SO.sub.3 R、卤素原子、R、OR、NR.sub.n、S(O).sub.q R、SiR.sub.3或P(O).sub.q R.sub.3，n=1、2或3；q=0、1或2)
• QUINOLINIUM SINGLE CRYSTALS FOR USE IN NONLINEAR OPTICS
  申请人：AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

  公开号：US20140204457A1

  公开（公告）日：2014-07-24

  The present invention relates to quinolinium-derived single crystals for use in nonlinear optics, which exhibit high molecular orientation and macroscopic optical nonlinearity. When the quinolinium-derived crystals according to the present invention are applied to THz wave light sources, higher THz wave generating efficiency may be obtained as compared with inorganic crystals or existing organic M crystals.

  本发明涉及用于非线性光学的喹啉衍生物单晶，其具有高分子取向和宏观光学非线性性。当根据本发明的喹啉衍生物晶体应用于THz波光源时，与无机晶体或现有有机M晶体相比，可以获得更高的THz波产生效率。
• Catalyst for olefin polymerization, process for the polymerization of olefin, and transition metal compound employable for the catalyst
  申请人：MITSUI PETROCHEMICAL INDUSTRIES, LTD.

  公开号：EP0519746A1

  公开（公告）日：1992-12-23

  A catalyst for use in the polymerization of at least one olefin comprising [A] a catalyst component comprising a compound of a transition metal of Group IVB of the Periodic Table having a ligand containing a -SO₃R group wherein R is an alkyl group, an alkyl group substituted with a halogen atom, an aryl group, or an aryl group substituted with a halogen atom or an alkyl group, and a ligand having a cyclopentadienyl skeleton, and [B] an organoaluminum oxy-compound. This provides an olefin polymer having excellent particle properties at high polymerization activities, and enables the production of a copolymer having a narrow composition distribution. The transition metal compound preferably is a novel compound of the formula (Cp is a group having a cyclopentadienyl skeleton, R is an optionally substituted alkyl or aryl group, and X is SO₃R, a halogen atom, R, OR, NRn, S(O)qR, SiR₃ or P(O)qR₃, wherein n = 1, 2 or 3; q = 0, 1 or 2).

  一种用于聚合至少一种烯烃的催化剂，包括 [A] 催化剂组分，包括元素周期表第 IVB 族过渡金属化合物，其配体含有 -SO₃R 基团，其中 R 是烷基、被卤素原子取代的烷基、芳基或被卤素原子或烷基取代的芳基，以及具有环戊二烯基骨架的配体，以及 [B] 有机铝氧化合物。 这样，烯烃聚合物在高聚合活性下具有优异的颗粒特性，并能生产出成分分布较窄的共聚物。过渡金属化合物最好是如下式的新型化合物 (Cp 是具有环戊二烯基骨架的基团，R 是任选取代的烷基或芳基，X 是 SO₃R、卤素原子、R、OR、NRn、S(O)qR、SiR₃ 或 P(O)qR₃，其中 n = 1、2 或 3；q = 0、1 或 2）。