A broad range of benzophenonehydrazone derivatives was prepared and tested against selected chewing insect pests, allowing the analysis of structure-activity relationships. Good activity was found only when the aromatic rings were substituted at the 4-positions with an halogen atom and a triflate or perhaloalkoxy group. In contrast, a number of substituents on the hydrazone part led to active compounds
The Alkylation of 6-(Trifluoromethyl)-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxide and Related Compounds. A New Reaction of ortho Esters with Sulfonamides<sup>1</sup>
作者:HARRY L. YALE、JOHN T. SHEEHAN
DOI:10.1021/jo01069a033
日期:1961.11
Inhibitors of gastric acid secretion: N-sulphonyl formamidines in a series of new histamine H2-receptor antagonists