N'-(11H-indeno[1,2-b]quinoxalin-11-ylidene)-4-methylbenzohydrazide | 1544692-18-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N'-(11H-indeno[1,2-b]quinoxalin-11-ylidene)-4-methylbenzohydrazide
• CAS: 1544692-18-3
• 化学式: C₂₃H₁₆N₄O
• 分子量: 364.406
• InChiKey: OGEFNXARKVRTAQ-UHFFFAOYSA-N

物化性质

• 熔点：
  198-200 °C
• 密度：
  1.32±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  28.0
• 可旋转键数：
  2.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  67.24
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  邻苯二胺 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 3.0h， 生成 N'-(11H-indeno[1,2-b]quinoxalin-11-ylidene)-4-methylbenzohydrazide
  参考文献：
  名称：

  Synthesis of novel indenoquinoxaline derivatives as potent α-glucosidase inhibitors

  摘要：

  A series of new N-(11H-Indeno[1,2-b]quinoxalin-11-ylidene)benzohydrazide derivatives (3a-3p) were synthesized and evaluated for their alpha-glucosidase inhibitory activity. The synthesized compounds 3d, 3f, 3g, 3k, 3n, 3p and 4 showed significant alpha-glucosidase inhibitory activity as compared to acrabose, a standard drug used to treat type II diabetes. Structures of the synthesized compounds were determined by using FT-IR, H-1 NMR, C-13 NMR, mass spectrometry and elemental analysis techniques. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.12.024

文献信息

• Synthesis of novel indenoquinoxaline derivatives as potent α-glucosidase inhibitors
  作者：Madiha Sahar Khan、Munawar Ali Munawar、Mohammad Ashraf、Umber Alam、Athar Ata、Abdullah Mohamed Asiri、Samina Kousar、Misbahul Ain Khan

  DOI：10.1016/j.bmc.2013.12.024

  日期：2014.2

  A series of new N-(11H-Indeno[1,2-b]quinoxalin-11-ylidene)benzohydrazide derivatives (3a-3p) were synthesized and evaluated for their alpha-glucosidase inhibitory activity. The synthesized compounds 3d, 3f, 3g, 3k, 3n, 3p and 4 showed significant alpha-glucosidase inhibitory activity as compared to acrabose, a standard drug used to treat type II diabetes. Structures of the synthesized compounds were determined by using FT-IR, H-1 NMR, C-13 NMR, mass spectrometry and elemental analysis techniques. (C) 2013 Elsevier Ltd. All rights reserved.