N-(4-Hydroxy-phenyl)-3,3-dimethyl-butyramide | 134106-95-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-Hydroxy-phenyl)-3,3-dimethyl-butyramide
• 英文别名: N-(4-Hydroxyphenyl)-3,3-dimethylbutanamide
• CAS: 134106-95-9
• 化学式: C₁₂H₁₇NO₂
• 分子量: 207.272
• InChiKey: ZYYGQDHVDFMJCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(4-Hydroxy-phenyl)-3,3-dimethyl-butyramide 、 3-methyl-1-{[methyl(phenyl)amino]carbonyl}-1H-imidazol-3-ium iodide 生成 Methyl-phenyl-carbamic acid 4-(3,3-dimethyl-butyrylamino)-phenyl ester
  参考文献：
  名称：

  Compounds and uses thereof for decreasing activity of hormone-sensitive lipase

  摘要：

  使用化合物抑制激素敏感脂肪酶，包含该化合物的制药组合物，使用这些化合物和组合物的治疗方法以及新型化合物。这些化合物是激素敏感脂肪酶的抑制剂，可用于治疗和/或预防需要降低激素敏感脂肪酶活性的医学疾病。

  公开号：

  US20030166644A1
• 作为产物：
  描述：

  3,3-二甲基-1-丁酸 、 对氨基苯酚 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 生成 N-(4-Hydroxy-phenyl)-3,3-dimethyl-butyramide
  参考文献：
  名称：

  Fenretinide Derivatives Act as Disrupters of Interactions of Serum Retinol Binding Protein (sRBP) with Transthyretin and the sRBP Receptor

  摘要：

  Serum retinol binding protein (sRBP) is released from the liver as a complex with transthyretin (TTR), a process under the control of dietary retinol. Elevated levels of sRBP may be involved in inhibiting cellular responses to insulin and in generating first insulin resistance and then type 2 diabetes, offering a new target for therapeutic attack for these conditions. A series of retinoid analogues were synthesized and examined for their binding to sRBP and their ability to disrupt the sRBP-TTR and sRBP-sRBP receptor interactions. A number inhibit the sRBP-TTR and sRBP-sRBP receptor interactions as well as or better than Fenretinide (FEN), presenting a potential novel dual mechanism of action and perhaps offering a new therapeutic intervention against type 2 diabetes and its development. Shortening the chain length of the FEN derivative substantially abolished binding to sRBP, indicating that the strength of the interaction the polyene chain region. Differences in potency against the sRBP-TTR and sRBP-sRBP receptor interactions suggest variant effects of the compounds on the two loops of sRBP guarding the entrance of the binding pocket that are responsible for these two protein-protein interactions.

  DOI：

  10.1021/jm200256g

文献信息

• Use of compounds for decreasing activity of hormone-sensitive
  申请人：——

  公开号：US20030166690A1

  公开（公告）日：2003-09-04

  Use of compounds to inhibit hormone-sensitive lipase, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and novel compounds. The present compounds are inhibitors of hormone-sensitive lipase and may be useful in the treatment and/or prevention of medical disorders where a decreased activity of hormone-sensitive lipase is desirable.

  使用化合物来抑制激素敏感性脂肪酶，包括这些化合物的制药组合物，使用这些化合物和组合物的治疗方法，以及新颖的化合物。这些化合物是激素敏感性脂肪酶的抑制剂，可用于治疗和/或预防需要降低激素敏感性脂肪酶活性的医学疾病。
• Use of compounds for decreasing activity of hormone-sensitive lipase
  申请人：Nero Nordisk A/S

  公开号：US07067517B2

  公开（公告）日：2006-06-27

  Use of compounds to inhibit hormone-sensitive lipase, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and novel compounds. The present compounds are inhibitors of hormone-sensitive lipase and may be useful in the treatment and/or prevention of medical disorders where a decreased activity of hormone-sensitive lipase is desirable.

  使用化合物抑制荷尔蒙敏感性脂肪酶，包括这些化合物的制药组合物，使用这些化合物和组合物的治疗方法，以及新型化合物。这些化合物是荷尔蒙敏感性脂肪酶的抑制剂，可能在需要降低荷尔蒙敏感性脂肪酶活性的医疗障碍的治疗和/或预防中有用。
• High-fluidity polycarbonates and process for preparing them
  申请人：ENICHEM S.p.A.

  公开号：EP0409312A2

  公开（公告）日：1991-01-23

  Linear, thermoplastic, aromatic polycarbonates having an average viscosimetric molecular weight comprised within the range of from 10,000 to 30,000, endowed with high fluidity in the molten state, are obtained by means of the use of chain capping agents of phenol-amidic nature, having the general formula: wherein: R, R₁, which can be either equal to, or different from, each other, are H or CH₃; R₂ is an either linear or branched alkyl radical, containing from 1 to 7 carbon atoms, or a cycloalkyl or alkylene-cycloalkyl radical of from 5 to 7 carbon atoms, with said alkyl, cycloalkyl or alkylene-cycloalkyl radicals possibly bearing a halogen atom.

  线性、热塑性、芳香族聚碳酸酯的平均粘度分子量在 10,000 至 30,000 之间，在熔融状态下具有高流动性，可通过使用具有通式的苯酚-氨基性质的链封端剂获得： 其中 R、R₁ 可以是 H 或 CH₃，也可以互不相同； R₂ 是含有 1 至 7 个碳原子的直链或支链烷基，或含有 5 至 7 个碳原子的环烷基或亚烷基环烷基，所述烷基、环烷基或亚烷基环烷基可能含有卤素原子。
• COMPOSITIONS FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE
  申请人：NOVO NORDISK A/S

  公开号：EP1458375A2

  公开（公告）日：2004-09-22
• US7067517B2
  申请人：——

  公开号：US7067517B2

  公开（公告）日：2006-06-27