Alcohols for the α-Alkylation of Methyl Ketones and Indirect Aza-Wittig Reaction Promoted by Nickel Nanoparticles
作者:Francisco Alonso、Paola Riente、Miguel Yus
DOI:10.1002/ejoc.200800729
日期:2008.10
Nickelnanoparticles have been found to activate primary alcohols used for the α-alkylation of ketones or in indirectaza-Wittigreactions. These processes involve hydrogen transfer from the alcohol to the intermediate α,β-unsaturated ketone or imine, respectively. All these reactions are carried out in the absence of any ligand, hydrogen acceptor or base under mild reaction conditions. For the first
Development of a convoluted polymeric nanopalladium catalyst: α-alkylation of ketones and ring-opening alkylation of cyclic 1,3-diketones with primary alcohols
作者:Yoichi M.A. Yamada、Yasuhiro Uozumi
DOI:10.1016/j.tet.2007.05.071
日期:2007.8
A novel solid-phase catalyst of palladium nanoparticles, nano-Pd-V, was prepared from PdCl2 with main-chain viologen polymersviacomplexation and reduction. This insoluble nanocatalyst nano-Pd-V efficiently promoted α-alkylation of ketones with primary alcohols in the presence of Ba(OH)2·H2O under atmospheric conditions without organic solvents. The nano-Pd-V catalyst was reused without loss of catalytic
A one-pot process for the enantioselective preparation of saturated secondary alcohols from propargyl ketones under hydrogen transfer conditions
作者:Nicolas Bogliotti、Peter I. Dalko、Janine Cossy
DOI:10.1016/j.tetlet.2005.08.008
日期:2005.10
Propargyl ketones can be directly transformed to enantio-enriched saturated secondary alcohols in a one-pot reaction using chiral RuCl[N-(tosyl)-1,2-diphenylethylenediamine)(p-cymene) and Pd/BaSO4 as catalysts, undertransfer hydrogenation conditions.
在转移条件下,使用手性RuCl [ N-(甲苯磺酰基)-1,2-二苯基乙二胺)(p - cymene)和Pd / BaSO 4作为催化剂,可以在一锅反应中将炔丙基酮直接转化为对映体富集的饱和仲醇。氢化条件。
Photodegradable Antimicrobial Agents: Synthesis and Mechanism of Degradation
作者:Vebjørn Eikemo、Bjarte Holmelid、Leiv K. Sydnes、Magne O. Sydnes
DOI:10.1021/acs.joc.2c00681
日期:2022.6.17
As a strategy to inactivate antimicrobialagents after use, we designed a range of ethanolamine derivatives where four of them possessed interesting activity. The ethanolamine moiety facilitates photodecomposition, which in a potential drug will take place after use. Herein, the synthetic preparation of these compounds and the mechanism of photoinactivation are described.