1-tetralylidenecyanothioacetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 1-tetralylidenecyanothioacetamide
• 英文别名: (2E)-2-cyano-2-(3,4-dihydro-2H-naphthalen-1-ylidene)ethanethioamide
• 化学式: C₁₃H₁₂N₂S
• 分子量: 228.318
• InChiKey: BMZRGSGCZWPVGS-VAWYXSNFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  81.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-tetralylidenecyanothioacetamide 在 哌啶 、 硫酸氢铵 、 四氯化锡 作用下， 以 乙醇 、 乙腈 为溶剂， 反应 51.0h， 生成 [(2R,3S,4S,5R,6R)-3,4,5-triacetyloxy-6-[1-cyano-4-(furan-2-yl)-2-sulfanylidene-5,6-dihydrobenzo[f]isoquinolin-3-yl]oxan-2-yl]methyl acetate
  参考文献：
  名称：

  Novel Synthesis of a New Class of Polynuclear Pyridinethione Nucleosides

  摘要：

  A novel synthesis of a new class of polynuclear pyridinethione glycosides utilizing the reactions of phenanthridine analogues and proportional to-bromoglucose or proportional to-bromogalactose tetraacetate as starting components is described.

  DOI：

  10.1080/07328319708001365
• 作为产物：
  描述：

  2-氰基硫代乙酰胺 、 3,4-二氢-1(2H)-萘酮 在 乙酸铵 、 溶剂黄146 作用下， 以 苯 为溶剂， 反应 4.0h， 以40%的产率得到1-tetralylidenecyanothioacetamide
  参考文献：
  名称：

  Rearrangement studies on 1-tetralylidenecyanothioacetamide: A different novel synthetic routes to strong fluorescent phenanthridine and phenanthrene analogues

  摘要：

  A novel synthesis of strong fluorescent phenanthridine and phenanthrene analogues utilizing arylmethylenecyanothioacetamides and 1-tetralylidenemalononitrile or 1-tetralylidenecyanothioacetamide and arylmethylenemalononitriles as starting components is described.

  DOI：

  10.1016/0040-4020(95)00063-e

文献信息

• NUCLEIC ACID COMPONENTS AND THEIR ANALOGUES: A NOVEL AND EFFICIENT METHOD FOR THE SYNTHESIS OF A NEW CLASS OF BIPYRIDYL AND BIHETEROCYCLIC-NITRO GEN THIOGLYCOSIDES FROM PYRIDINE-2(1H)-THIONES
  作者：Galal H. Elgemeie、Mervat M. El-Enany、Mohamed M. Ismail、Eman K. Ahmed

  DOI：10.1081/ncn-120014820

  日期：——

  ABSTRACT A novel synthesis of a new class of bipyridyl and biheterocyclic-nitrogen thioglycosides utilizing the reactions of heterocyclic substituted pyridine-2(1H)-thiones and α-bromoglucose or α-bromogalactose tetraacetate as starting components is described.

  摘要描述了利用杂环取代的吡啶-2(1H)-硫酮和 α-溴葡萄糖或 α-溴半乳糖四乙酸酯作为起始组分的反应，合成了一类新的联吡啶和双杂环氮硫糖苷。
• Rearrangement studies on 1-tetralylidenecyanothioacetamide: A different novel synthetic routes to strong fluorescent phenanthridine and phenanthrene analogues
  作者：Galal E.H. Elgemeie、Nahed M. Fathy

  DOI：10.1016/0040-4020(95)00063-e

  日期：1995.3

  A novel synthesis of strong fluorescent phenanthridine and phenanthrene analogues utilizing arylmethylenecyanothioacetamides and 1-tetralylidenemalononitrile or 1-tetralylidenecyanothioacetamide and arylmethylenemalononitriles as starting components is described.
• Novel Synthesis of a New Class of Polynuclear Pyridinethione Nucleosides
  作者：Galal E. H. Elgemeie、Adel M. E. Attia、Nahed M. Fathy

  DOI：10.1080/07328319708001365

  日期：1997.4

  A novel synthesis of a new class of polynuclear pyridinethione glycosides utilizing the reactions of phenanthridine analogues and proportional to-bromoglucose or proportional to-bromogalactose tetraacetate as starting components is described.