蒽醌醇衍生物 | 56975-13-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 蒽醌醇衍生物
• 英文名称: 1-dodecyl-2-<(2-hydroxyethyl)amino>ethanol
• 英文别名: 1-(2-Hydroxyethylamino)tetradecan-2-ol
• CAS: 56975-13-4
• 化学式: C₁₆H₃₅NO₂
• 分子量: 273.459
• InChiKey: IEXSDLUUGZIKLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  19
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  蒽醌醇衍生物 在 吡啶 、 正丁基锂 作用下， 反应 0.58h， 生成 N-tosyl-1-dodecyl-2-<(2-tosyloxyethyl)amino>ethanol
  参考文献：
  名称：

  Selective delivery of cytotoxic compounds to cells by the LDL pathway

  摘要：

  Cancer cells need cholesterol to make new membrane. They get it either by de novo synthesis or from low-density lipoprotein (LDL), or both. Some types of cancer have very high LDL requirements. LDL particles, which circulate in the blood, contain a cholesteryl ester core surrounded by a phospholipid coat containing apoproteins that are recognized by LDL receptors on cell surfaces. After attachment to cells, LDL is endocytosed into lysosomes, where the core is exposed and hydrolyzed. A technique is known whereby LDL can be isolated, its core removed and replaced by a compatible lipophilic substance, and then reconstituted into intact LDL particles that are recognized and internalized by cells in the normal manner. A series of cytotoxic compounds has been synthesized, designed to be compatible with reconstituted LDL, and directed against cancers that copiously internalize LDL. They were evaluated by measuring the toxicity of reconstituted LDL toward test cells bearing LDL receptors. Selectivity was determined by comparison, either with mutant cells with few LDL receptors or with reconstituted methylated LDL (which is not recognized by LDL receptors) on normal cells. Two compounds, 19 and 25, were found that reconstitute well, kill or arrest the test cells at reasonably low concentrations, and are completely selective, suggesting that they are delivered to cells exclusively via the LDL pathway.

  DOI：

  10.1021/jm00374a017
• 作为产物：
  描述：

  1-十四烯 在 间氯过氧苯甲酸 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 48.0h， 生成 蒽醌醇衍生物
  参考文献：
  名称：

  Selective delivery of cytotoxic compounds to cells by the LDL pathway

  摘要：

  Cancer cells need cholesterol to make new membrane. They get it either by de novo synthesis or from low-density lipoprotein (LDL), or both. Some types of cancer have very high LDL requirements. LDL particles, which circulate in the blood, contain a cholesteryl ester core surrounded by a phospholipid coat containing apoproteins that are recognized by LDL receptors on cell surfaces. After attachment to cells, LDL is endocytosed into lysosomes, where the core is exposed and hydrolyzed. A technique is known whereby LDL can be isolated, its core removed and replaced by a compatible lipophilic substance, and then reconstituted into intact LDL particles that are recognized and internalized by cells in the normal manner. A series of cytotoxic compounds has been synthesized, designed to be compatible with reconstituted LDL, and directed against cancers that copiously internalize LDL. They were evaluated by measuring the toxicity of reconstituted LDL toward test cells bearing LDL receptors. Selectivity was determined by comparison, either with mutant cells with few LDL receptors or with reconstituted methylated LDL (which is not recognized by LDL receptors) on normal cells. Two compounds, 19 and 25, were found that reconstitute well, kill or arrest the test cells at reasonably low concentrations, and are completely selective, suggesting that they are delivered to cells exclusively via the LDL pathway.

  DOI：

  10.1021/jm00374a017

文献信息

• RESIN COMPOSITION AND MOLDED PRODUCT OBTAINED BY MOLDING THE RESIN COMPOSITION
  申请人：Shibuya Atsushi

  公开号：US20100074083A1

  公开（公告）日：2010-03-25

  Provided are a resin composition comprising 100 parts by mass of the polymer having an alicyclic structure at least in a part of a repeating structural unit and 0.05 to 5 parts by mass of a hindered amine compound having a carbon atom at a ratio of from 67% by weight to 80% by weight in the molecular structure and having a molecular weight of from 500 to 3500, a novel piperidine derivative having a piperidylaminotriazine skeleton, a molded product such as an optical component obtained by molding the resin composition, and an optical pickup device which employs the optical component.

  提供的是一种树脂组合物，包括100质量部分具有环脂环结构的聚合物和0.05至5质量部分的分子结构中至少有部分碳原子的受阻胺化合物，其分子结构中碳原子占比从67%到80%。分子量在500至3500之间，一种具有哌啶氨基三嗪骨架的新型哌啶衍生物，以及通过模压树脂组合物获得的光学元件等成型产品，以及采用该光学元件的光学拾取器件。
• Resin composition and optical component
  申请人：Shibuya Atsushi

  公开号：US20090310471A1

  公开（公告）日：2009-12-17

  There are provided a resin composition that is suitable for an optical component which, while maintaining moldability, low birefringence, heat resistance, mass productivity, mechanical strength, and light transmittance, hardly exhibits a low light transmittance during the use of a blue-violet laser beam source and a deterioration in optical properties, and an optical component produced by molding the resin composition, and a optical pickup device using the optical component. The present invention provides a resin composition comprising 0.05 to 5 parts by weight of the specific hindered amine compound based on 100 parts by weight of the polymer having an alicyclic structure in at least a part of repeating structural unit, an optical component produced by molding the resin composition, and a optical pickup device using the optical component.

  提供了一种树脂组合物，适用于光学元件，同时保持可塑性、低双折射、耐热性、大规模生产能力、机械强度和光透过率，且在使用蓝紫色激光光源时几乎不表现出低光透过率和光学性能的恶化，以及通过模塑树脂组合物制成的光学元件和使用该光学元件的光学拾取装置。本发明提供了一种树脂组合物，其中包含100份重量的具有脂环结构的聚合物中的至少一部分重复结构单元，以0.05至5份重量的特定阻碍胺化合物为基础，以及通过模塑树脂组合物制成的光学元件和使用该光学元件的光学拾取装置。
• Schmiermittelzusammensetzungen
  申请人：CIBA-GEIGY AG

  公开号：EP0239536A2

  公开（公告）日：1987-09-30

  Schmiermittelzusammensetzungen mit ausgezeichneten korrosionsin­hibierenden und antioxidativen Eigenschaften enthaltend einen überwiegenden Anteil eines mineralischen Schmieröls und einen geringen, funktionell-wirksamen Anteil einer Additivzusammensetzung aus A) einem Hydroxyalkylalkanolamin-Korrosionsinhibitor, B) einem phenolischen Antioxidans und/oder C) einem aminischen Antioxidans und D) einem Metalldeaktivator vom Azol-Typ.

  具有优异缓蚀和抗氧化性能的润滑油组合物，其主要成分为矿物润滑油，次要成分为功能有效的下列添加剂组合物 A) 一种羟基烷基醇胺缓蚀剂、 B) 酚类抗氧化剂和/或 C) 氨基抗氧化剂和 D) 一种唑类金属失活剂。
• RESIN COMPOSITION AND OPTICAL COMPONENT
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1878769A1

  公开（公告）日：2008-01-16

  There are provided a resin composition that is suitable for an optical component which, while maintaining moldability, low birefringence, heat resistance, mass productivity, mechanical strength, and light transmittance, hardly exhibits a low light transmittance during the use of a blue-violet laser beam source and a deterioration in optical properties, and an optical component produced by molding the resin composition, and a optical pickup device using the optical component. The present invention provides a resin composition comprising 0.05 to 5 parts by weight of the specific hindered amine compound based on 100 parts by weight of the polymer having an alicyclic structure in at least a part of repeating structural unit, an optical component produced by molding the resin composition, and a optical pickup device using the optical component.

  本发明提供了一种适用于光学部件的树脂组合物，该光学部件在保持成型性、低双折射、耐热性、质量生产性、机械强度和透光率的同时，在使用蓝紫色激光光束源时几乎不会出现透光率低和光学特性劣化的现象，还提供了一种通过成型该树脂组合物生产的光学部件，以及一种使用该光学部件的光学拾取装置。本发明提供了一种树脂组合物，该树脂组合物包含 0.05 至 5 份（按重量计）特定受阻胺化合物（以 100 份（按重量计）具有脂环结构的聚合物的至少一部分重复结构单元为基准）、通过模塑该树脂组合物生产的光学元件以及使用该光学元件的光学拾取装置。
• Antistatic composition
  申请人：——

  公开号：US20040171762A1

  公开（公告）日：2004-09-02

  Polymer compositions comprising a) a polymer substrate selected from the group consisting of the polyolefins, polyesters, polyamides and polylactic acids and b) a combination of i) at least one permanent antistatic additive selected from the group consisting of the polyetheresteramides and ii) at least one migratory antistatic additive selected from the group consisting of the alkylsulfonic acid salts, the alkyl diethanolamines and the alkyl diethanolamides, are effectively antistatic.

  聚合物组合物，包括 a) 选自聚烯烃、聚酯、聚酰胺和聚乳酸的聚合物基材，以及 b) 以下物质的组合 i) 至少一种选自聚醚酯酰胺类的永久抗静电添加剂和 从烷基磺酸盐、烷基二乙醇胺和烷基二乙醇酰胺组成的组中选出的至少一种抗静电迁移添加剂、 可有效抗静电。