6,7-dimethoxy-3-propylquinoxalin-2-ol | 99208-21-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6,7-dimethoxy-3-propylquinoxalin-2-ol
• CAS: 99208-21-6
• 化学式: C₁₃H₁₆N₂O₃
• 分子量: 248.282
• InChiKey: DHWDZEBFXYKZFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.31
• 重原子数：
  18.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  64.47
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  6,7-dimethoxy-3-propylquinoxalin-2-ol 在 三氯氧磷 作用下， 生成
  参考文献：
  名称：

  Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor

  摘要：

  Following our previous publication describing the biological profiles, we herein describe the structure-activity relationships of a core set of quinoxalines as the hGLP-1 receptor agonists. The most potent and efficacious compounds are 6,7-dichloroquinoxalines bearing an alkyl sulfonyl group at the C-2 position and a secondary alkyl amino group at the C-3 position. These findings serve as a valuable starting point for the discovery of more drug-like small molecule agonists for the hGLP-1 receptor. (C) Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.06.086
• 作为产物：
  描述：

  1,2-二氨基-4,5-二甲氧基苯 、 alkaline earth salt of/the/ methylsulfuric acid 在 溶剂黄146 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 6,7-dimethoxy-3-propylquinoxalin-2-ol
  参考文献：
  名称：

  Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor

  摘要：

  Following our previous publication describing the biological profiles, we herein describe the structure-activity relationships of a core set of quinoxalines as the hGLP-1 receptor agonists. The most potent and efficacious compounds are 6,7-dichloroquinoxalines bearing an alkyl sulfonyl group at the C-2 position and a secondary alkyl amino group at the C-3 position. These findings serve as a valuable starting point for the discovery of more drug-like small molecule agonists for the hGLP-1 receptor. (C) Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.06.086

文献信息

• Hara, Shuuji; Yamaguchi, Masatoshi; Nakamura, Masaru, Chemical and pharmaceutical bulletin, 1985, vol. 33, # 8, p. 3493 - 3498
  作者：Hara, Shuuji、Yamaguchi, Masatoshi、Nakamura, Masaru、Ohkura, Yosuke

  DOI：——

  日期：——