6-formyl-N-methyl-2-naphthylamine | 1018839-94-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 6-formyl-N-methyl-2-naphthylamine
• 英文别名: 6-formyl-2-(N-methylamino)naphthalene；6-(methylamino)naphthalene-2-carbaldehyde
• CAS: 1018839-94-5
• 化学式: C₁₂H₁₁NO
• 分子量: 185.225
• InChiKey: CXMRVPIRPHNCAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-formyl-N-methyl-2-naphthylamine 在 1-羟基苯并三唑 、 对甲苯磺酸 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 51.0h， 生成
  参考文献：
  名称：

  一种高灵敏度的双光子荧光探针，用于检测活组织中的线粒体锌离子。

  摘要：

  我们报告了一个高灵敏度的双光子探针（SZn2-Mito），该探针显示响应Zn（2+）的70倍双光子激发的荧光增强，并可以在大鼠海马切片中选择性检测线粒体Zn（2+），通过使用双光子显微镜，可以观察到100-200微米的深度。

  DOI：

  10.1039/c2cc31077e
• 作为产物：
  描述：

  6-methylamino-2-naphthonitrile 在 二异丁基氢化铝 、 硫酸 、 水 、 氯化铵 作用下， 以 甲苯 为溶剂， 反应 4.5h， 以41%的产率得到6-formyl-N-methyl-2-naphthylamine
  参考文献：
  名称：

  一种用于硒蛋白检测的荧光探针化合物及其制备方法

  摘要：

  本发明涉及一种用于硒蛋白检测的荧光探针化合物，所述化合物结构如式Ⅰ所示。与传统检测技术相比，非侵入性的荧光探针检测操作简单、方便、快速，灵敏度高，选择性好，响应时间短，可对检测目标物进行原位、实时监测，且应用范围广泛。式Ⅰ。

  公开号：

  CN109251160A

文献信息

• Two-photon dyes for real-time imaging of lipid rafts
  申请人：Cho Bong-Rae

  公开号：US20080071106A1

  公开（公告）日：2008-03-20

  Two-photon dyes for real-time imaging of lipid rafts are provided. The two-photon dyes emit fluorescence with high intensity in the environments of cell membranes and can be used to clearly discriminate the hydrophobic and hydrophilic domains of the cell membranes. Therefore, the use of the two-photon dyes enables satisfactory imaging of actual lipid raft domains. In addition, since the two-photon dyes show no cytotoxicity, they can be suitably used in bioimaging applications, for example, real-time imaging of lipid rafts over a long period of time.

  提供了用于实时成像脂质微囊的双光子染料。这些双光子染料在细胞膜环境中发出高强度的荧光，可以清晰地区分细胞膜的疏水和亲水区域。因此，使用双光子染料可以令人满意地成像实际脂质微囊区域。此外，由于双光子染料不显示细胞毒性，它们可以适当地用于生物成像应用，例如长时间的实时成像脂质微囊。
• [EN] COMPOUNDS AND METHODS FOR OPTICAL SENSING OF ELECTRICAL ACTIVITY IN BIOLOGICAL SYSTEMS<br/>[FR] COMPOSÉS ET PROCÉDÉS DE DÉTECTION OPTIQUE D'ACTIVITÉ ÉLECTRIQUE DANS DES SYSTÈMES BIOLOGIQUES
  申请人：UNIV CONNECTICUT

  公开号：WO2019140270A1

  公开（公告）日：2019-07-18

  Disclosed are tethered chromophore compositions comprising a membrane-spanning tether. The compounds can include covalently tethered fluorophore-quencher combinations useful for measuring action potentials and other fast electrical events in cells and tissues.

  公开了一种包括跨膜系链的系链色素组合物。这些化合物可以包括共价系链的荧光物质-猝灭剂组合，用于测量细胞和组织中的动作电位和其他快速电事件。
• 이광자 형광 프로브, 이의 제조방법 및 이를 이용한 pH 이미지화 방법
  申请人：AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION 아주대학교산학협력단(220040257423) BRN ▼124-82-14602

  公开号：KR101584606B1

  公开（公告）日：2016-01-13

  본 발명은 pH를 이미지화하는 이광자 형광 프로브에 관한 것으로서, 본 발명의 이광자 형광 프로브는 벤즈이미다졸 구조 유도체를 기반으로 하여 산성 영역의 pH 및 그 변화량을 감지한다. 상기 프로브는 고유 등방사성 점, 적은 독성 및 높은 광안정성을 가지며, pH 4-7에서 이광자 형광의 색 변화를 나타내면서 pH를 0.001 단위로 측정할 수 있다. 본 발명에 따른 이광자 형광 프로브는 살아있는 세포와 생체 조직 내부에 선택적으로 염색됨과 동시에 산성 pH와 반응하여 강한 형광의 색 변화(청색-녹색)를 나타낸다. 또한 물에 대한 높은 용해도와 적은 분자량으로 인하여 세포에 쉽게 로딩될 수 있다. 또한, 60분 이상의 시간에 걸쳐 생체 세포 및 100-200 μm 깊이의 생체 조직에서 선택적으로 pH를 탐지할 수 있으므로 생체 세포 또는 온건한 생체 조직 내의 pH의 분포 및 활성을 비율영상으로 조사할 수 있다. 이에 따라 pH의 정량적인 분석이 가능하고 서로 다른 시료의 비교 분석이 가능하게 됨으로써 pH와 관련된 생명과학 연구와 질병의 조기 진단, 진단 시약과 치료제의 개발 등에 크게 기여할 수 있다.

  This invention relates to a photon fluorescent probe that visualizes pH. The photon fluorescent probe of this invention is based on a benzimidazole derivative structure and detects the pH of acidic regions and its changes. The probe has inherent isotropic emission, low toxicity, and high photostability, and can indicate color changes in photon fluorescence between pH 4-7, allowing for pH measurement in increments of 0.001 units. The photon fluorescent probe according to this invention selectively stains living cells and biological tissues internally while reacting with acidic pH to show a strong fluorescence color change (blue-green). Additionally, due to high solubility in water and low molecular weight, it can be easily loaded into cells. Furthermore, it can selectively detect pH in living cells over a period of 60 minutes or more and in biological tissues at depths of 100-200 μm, enabling the investigation of the distribution and activity of pH in living cells or intact biological tissues through ratio imaging. Therefore, it enables quantitative analysis of pH, comparison analysis of different samples, and can significantly contribute to life science research related to pH, early diagnosis of diseases, and the development of diagnostic reagents and treatments.
• 一种用于多硫化物检测的荧光探针化合物及其制备方法
  申请人：中国科学院烟台海岸带研究所

  公开号：CN109232360A

  公开（公告）日：2019-01-18

  本发明涉及一种用于多硫化物检测的荧光探针化合物及其制备方法。所述化合物结构如式Ⅰ所示。与传统检测技术相比，非侵入性的荧光探针检测操作简单、方便、快速，灵敏度高，选择性好，响应时间短，可对检测目标物进行原位、实时监测，且应用范围广泛。式I。
• High Spatiotemporal Resolution Observation of Glutathione Hydropersulfides in Living Cells and Tissue via a Two-Photon Ratiometric Fluorescent Probe
  作者：Yue Wang、Liangwei Zhang、Songzi Zhang、Zhe Liu、Lingxin Chen

  DOI：10.1021/acs.analchem.9b01511

  日期：2019.6.18

  the role of GSSH in biological systems is a lack of detection tools with high spatiotemporal resolution. To address the issues, we are seeking novel chemical tools for GSSH detection. We herein develop the first two-photon ratiometric fluorescent probe (TP-Dise) for GSSH detection with high spatial and temporal resolution in living cells and tissue. On the basis of our probe TP-Dise, we investigate

  谷胱甘肽氢过氧化物（GSSH）被认为在信号转导，氧化还原稳态和代谢调节中起关键作用。但是，GSSH在这些方面的详细生物学功能极为模棱两可。理解GSSH在生物系统中的作用的主要障碍是缺乏具有高时空分辨率的检测工具。为了解决这些问题，我们正在寻找用于GSSH检测的新型化学工具。我们在这里开发了第一个两光子比例荧光探针（TP-DiSE）用于GSSH检测，在活细胞和组织中具有高时空分辨率。在我们的探针TP-DiSE的基础上，我们研究了GSSH的生物合成，结果表明GSSH主要来自两种硫转移酶CBS和CSE。此外，我们首次探索了GSSH在保护细胞免受汞离子诱导的细胞损伤中的生物学功能。实验结果表明，汞离子可能通过引起线粒体自噬而诱导细胞死亡。GSSH既可以充当拮抗剂，也可以充当抗氧化剂，并可以有效减轻汞胁迫所造成的损害。