4-Morpholino-pyridine-2,6-dicarboxylic acid | 1186079-88-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-Morpholino-pyridine-2,6-dicarboxylic acid
• 英文别名: 4-morpholin-4-ylpyridine-2,6-dicarboxylic acid
• CAS: 1186079-88-8
• 化学式: C₁₁H₁₂N₂O₅
• 分子量: 252.227
• InChiKey: HEUCIBREYIIVAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  100
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  乙醇 、 4-Morpholino-pyridine-2,6-dicarboxylic acid 在 硫酸 作用下， 以95%的产率得到diethyl 4-(4-morpholinyl)-pyridine-2,6-dicarboxylate
  参考文献：
  名称：

  Optimization of a series of 2,4-diaminopyridines as neuropeptide Y Y1 receptor antagonists with reduced hERG activity

  摘要：

  The synthesis and evaluation of a series of 2,4-diaminopyridine-based neuropeptide Y Y1 ( NPY Y1) receptor antagonists are described. Compound 1 was previously reported by our laboratory to be a potent and selective Y1 antagonist; however, 1 was also found to have potent hERG inhibitory activity. The main focus of this communication is structure-activity relationship development aimed at eliminating the hERG activity of 1. This resulted in the identification of compound 3d as a potent and selective NPY Y1 antagonist with reduced hERG liability. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.05.069
• 作为产物：
  描述：

  吗啉 、 4-氯吡啶-2,6-二羧酸 在 水 作用下， 反应 18.5h， 生成 4-Morpholino-pyridine-2,6-dicarboxylic acid
  参考文献：
  名称：

  Luminescent lanthanide complex, and articles and inks containing the luminescent complex

  摘要：

  发光镧系络合物和含有该络合物的油墨，以及其制备方法和包括该络合物的物品，其中该络合物包括以下公式： 其中，M从碱金属阳离子Li+，Na+，K+，Rb+和Cs+及其混合物中选择，并存在于中和络合物的电荷中；Ln从Ce，Pr，Nd，Sm，Eu，Gd，Tb，Dy，Ho，Er，Tm和Yb的三价稀土阳离子及其混合物中选择；R是C5到C6杂环芳基；Y是通过N原子与R连接的可选择取代的C3-C8杂环烷基；n是3或5的整数；x是0或1的整数。

  公开号：

  US09163155B2

文献信息

• [EN] 4-SUBSTITUTED PYRIDINE-2,6-DICARBOXYLIC ACID DERIVATIVES AND METHOD OF PREPARING SAME<br/>[FR] DÉRIVÉS D'ACIDE PYRIDINE-2,6-DICARBOXYLIQUE 4-SUBSTITUÉS ET LEUR PROCÉDÉ DE PRÉPARATION
  申请人：OKINAWA INST OF SCIENCE AND TECHNOLOGY SCHOOL CORP

  公开号：WO2016038890A1

  公开（公告）日：2016-03-17

  The present invention relates to novel 4-substituted pyridine-2,6-dicarboxylic acid derivatives, compounds of formula I, wherein R1 and R2are defined herein. The compounds of formula I are useful for making pharmaceutical compositions to treat proliferative diseases. The present invention also relates to concise methods for preparing compounds of formula I that may be performed under mild reaction conditions.

  本发明涉及新颖的4-取代吡啶-2,6-二羧酸衍生物，化合物的化学式为I，其中R1和R2如本文所定义。化合物的化学式I可用于制备用于治疗增殖性疾病的药物组合物。本发明还涉及用于制备化合物的简洁方法，该方法可在温和的反应条件下进行。
• LUMINESCENT LANTHANIDE COMPLEX, AND ARTICLES AND INKS CONTAINING THE LUMINESCENT COMPLEX
  申请人：Sicpa Holding SA

  公开号：US20140093664A1

  公开（公告）日：2014-04-03

  Luminescent lanthanide complex and inks containing the complex as well as its method of production and article including the complex, wherein the complex includes the formula: wherein M is chosen from the alkali cations Li + , Na + , K + , Rb + and Cs + and mixtures thereof and is present to neutralize charge of the complex; wherein Ln is chosen from the trivalent rare-earth cations of Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, and Yb and mixtures thereof; wherein R is a C 5 to C 6 heteroaryl: wherein Y is an optionally substituted C 3 -C 8 heterocycloalkyl moiety linked to R by an N atom; wherein n is an integer of 3 or 5; and wherein x is an integer of 0 or 1.

  发光镧系络合物和含有该复合物的油墨，以及其制备方法和包括该复合物的物品，其中该复合物的化学式为：其中M选自碱金属阳离子Li+，Na+，K+，Rb+和Cs+及其混合物，并存在于中和该复合物的电荷；其中Ln选自Ce，Pr，Nd，Sm，Eu，Gd，Tb，Dy，Ho，Er，Tm和Yb的三价稀土阳离子及其混合物；其中R是C5到C6的杂环芳基：其中Y是通过N原子与R连接的可选择取代的C3-C8杂环烷基基团；其中n是3或5的整数；其中x是0或1的整数。
• 4-SUBSTITUTED PYRIDINE-2,6-DICARBOXYLIC ACID DERIVATIVES AND METHOD OF PREPARING SAME
  申请人：Okinawa Institute of Science and Technology School Corporation

  公开号：EP3191451B1

  公开（公告）日：2019-06-05
• US9163155B2
  申请人：——

  公开号：US9163155B2

  公开（公告）日：2015-10-20
• Optimization of a series of 2,4-diaminopyridines as neuropeptide Y Y1 receptor antagonists with reduced hERG activity
  作者：Minoru Kameda、Kensuke Kobayashi、Hirokatsu Ito、Hiroshi Miyazoe、Toshiaki Tsujino、Chisato Nakama、Hiroshi Kawamoto、Makoto Ando、Sayaka Ito、Tomoki Suzuki、Tetsuya Kanno、Takeshi Tanaka、Yoshio Tahara、Takeshi Tani、Sachiko Tanaka、Shigeru Tokita、Nagaaki Sato

  DOI：10.1016/j.bmcl.2009.05.069

  日期：2009.8

  The synthesis and evaluation of a series of 2,4-diaminopyridine-based neuropeptide Y Y1 ( NPY Y1) receptor antagonists are described. Compound 1 was previously reported by our laboratory to be a potent and selective Y1 antagonist; however, 1 was also found to have potent hERG inhibitory activity. The main focus of this communication is structure-activity relationship development aimed at eliminating the hERG activity of 1. This resulted in the identification of compound 3d as a potent and selective NPY Y1 antagonist with reduced hERG liability. (C) 2009 Elsevier Ltd. All rights reserved.