diethyl 2,6-dimethyl-4,4'-bipyridine-3,5-dicarboxylate | 54756-40-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: diethyl 2,6-dimethyl-4,4'-bipyridine-3,5-dicarboxylate
• 英文别名: 2,6-Dimethyl-[4,4']bipyridinyl-3,5-dicarboxylic acid diethyl ester；diethyl 2,6-dimethyl-4-pyridin-4-ylpyridine-3,5-dicarboxylate
• CAS: 54756-40-0
• 化学式: C₁₈H₂₀N₂O₄
• 分子量: 328.368
• InChiKey: XDVRFPUPJSNREP-UHFFFAOYSA-N

物化性质

• 熔点：
  112 °C(Solv: ethanol (64-17-5))
• 沸点：
  425.2±45.0 °C(Predicted)
• 密度：
  1.162±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  78.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  diethyl 2,6-dimethyl-4,4'-bipyridine-3,5-dicarboxylate 生成 1,1'-(1,4-phenylenebis(methylene))bis(3',5'-bis(ethoxycarbonyl)-2',6'-dimethyl-[4,4'-bipyridin]-1-ium) bis-tetrafluoroborate
  参考文献：
  名称：

  Electrochromic two-core viologen derivatives and optical articles containing them

  摘要：

  公开号：

  EP2848668B1
• 作为产物：
  描述：

  2,6-二甲基-4-吡啶-4-基-1,4-二氢吡啶-3,5-二羧酸二乙酯 在 甲烷磺酸 、 silica gel 、 sodium nitrite 作用下， 反应 0.25h， 以88%的产率得到diethyl 2,6-dimethyl-4,4'-bipyridine-3,5-dicarboxylate
  参考文献：
  名称：

  在非均相和无溶剂条件下，在甲磺酸/ NaNO 2 /湿SiO 2存在下对1,4-二氢吡啶进行芳构化

  摘要：

  在湿的SiO 2存在下，将甲磺酸和亚硝酸钠的混合物用作有效的氧化剂，用于在温和和非均相条件下以极好的收率将1,4-二氢吡啶氧化为相应的吡啶衍生物。

  DOI：

  10.1002/jhet.5570430131

文献信息

• ELECTROCHROMIC TWO-CORE VIOLOGEN DERIVATIVES AND OPTICAL ARTICLES CONTAINING THEM
  申请人：ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE)

  公开号：US20160221949A1

  公开（公告）日：2016-08-04

  The present invention relates to a group of novel electrochromic materials. More specifically, it relates to electrochromic materials having two-core viologens and the use of these two-core viologens as a variable transmittance medium for the manufacture of an optical article, such as an ophthalmic lens.

  本发明涉及一组新型电致变色材料。更具体地，涉及具有双核紫精的电致变色材料，以及将这些双核紫精用作可变透射率介质制造光学制品，如眼镜镜片。
• Studies on Cerebral Protective Agents. I. Novel 4-Arylpyrimidine Derivatives with Anti-anoxic and Anti-lipid Peroxidation Activities.
  作者：Atsushi KUNO、Yoshie SUGIYAMA、Kiyotaka KATSUTA、Toshiharu KAMITANI、Hisashi TAKASUGI

  DOI：10.1248/cpb.40.1452

  日期：——

  Novel 4-arylpyrimidine derivatives were synthesized by the oxidation of 4-aryl-1, 4-dyhydropyrimidines, and their effects on anti-anoxic (AA) activity in mice and anti-lipid peroxidation (ALP) activity in rat mitochondria were investigated. Among these compounds, ethyl 6-methyl-2-phenyl-4-(4-pyridyl)-5-pyrimidinecarboxylate (4b) has AA activity (10mg/kg, i.p.) and ethyl 6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxylate (4f) has ALP activity (73% inhibition at 10<-5>g/ml). The latter compound (100mg/kg, i.p.) was also effective on arachidonate-induced cerebral edema in rats with comparable potency to that of vitamin E.

  通过氧化4-芳基-1,4-二氢嘧啶合成了新型4-芳基嘧啶衍生物，并研究了它们对小鼠抗缺氧（AA）活性和大鼠线粒体抗脂质过氧化（ALP）活性的影响。在这些化合物中，乙基6-甲基-2-苯基-4-(4-吡啶基)-5-嘧啶羧酸酯（4b）具有AA活性（10mg/kg，腹腔注射），而乙基6-甲基-4-(3-硝基苯基)-2-苯基-5-嘧啶羧酸酯（4f）具有ALP活性（73%抑制在10μg/ml）。后者化合物（100mg/kg，腹腔注射）对大鼠花生四烯酸引起的脑水肿也有效，其效力与维生素E相当。
• Simple Brønsted acid catalyzed C–H functionalization: efficient access to poly-substituted pyridines
  作者：Shujun Lai、Xuwen Ren、Jinzhong Zhao、Zhuo Tang、Guangxun Li

  DOI：10.1016/j.tetlet.2016.05.061

  日期：2016.7

  An exceptionally simple and environmentally friendly methodology has been developed for directly functionalizing the benzylic C–H bond of the poly-substituted pyridines with aromatic imines. Simple Brønsted acid catalysts including salicylic acid and TsOH were successfully employed. Different types of poly-substituted pyridines could be efficiently obtained with moderate yields. Traditional ways to

  已经开发了一种非常简单且对环境友好的方法，用于将多取代吡啶的苄基CH键与芳族亚胺直接官能化。成功地使用了简单的布朗斯台德酸催化剂，包括水杨酸和TsOH。可以以中等收率有效地获得不同类型的多取代吡啶。制备这类吡啶的传统方法涉及相应的Hantzsch 1,4-二氢吡啶的芳构化，而该方法大大简化了合成步骤。
• NaI readily mediated oxidative aromatization of Hantzsch 1,4-dihydropyridines with hydrogen peroxide at room temperature: A green procedure
  作者：D. Shahabi、M. A. Amrollahi、A. A. Jafari

  DOI：10.1007/bf03246562

  日期：2011.12

  The oxidative conversion of 1,4-dihydropyridines to give the corresponding pyridine derivatives in excellent yields was easily effected using the catalytic amount of NaI in combination with H2O2 (30%) as a green external oxidant. The process is highly green wherein the solid products are easily filtered out after the addition of ice-water to the reaction mixture. This non-transition metal catalyst

  使用催化量的NaI和H 2 O 2（30％）作为绿色外部氧化剂，可以轻松实现1,4-二氢吡啶的氧化转化，从而以优异的收率得到相应的吡啶衍生物。该方法是高度绿色的，其中在将冰水添加到反应混合物中之后，容易将固体产物滤出。这种非过渡金属催化剂具有成本效益，提供了简单的后处理和易于分离的产物。
• Oxidation of 1,4-Dihydropyridines and 3,4-Dihydropyrimidin-2(1<i>H</i>)-ones to Substituted Pyridines and Pyrimidinones Using Ca(OCl)₂in Aqueous Media
  作者：Fatemeh Tamaddon、Zahra Razmi

  DOI：10.1080/00397911003587523

  日期：2011.1.31

  [image omitted] 1,4-Dihydropyridines and 3,4-dihydropyrimidin-2(1H)-ones obtained from the Hantzsch and Biginelli reactions undergo readily oxidative dehydrogenation by using calcium hypochlorite in very short times. These calcium stimulator drugs were oxidized under reaction conditions next to the in vivo transformations at room temperature.