4-羟基-2-甲氧基-6-甲基-苯甲酸 | 3733-95-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-羟基-2-甲氧基-6-甲基-苯甲酸
• 英文名称: 4-hydroxy-2-methoxy-6-methylbenzoic acid
• 英文别名: isoevernic acid；Isoeverninsaeure; 2-Methoxy-4-hydroxy-6-methyl-benzoesaeure；2-Methoxy-4-hydroxy-6-methyl-benzoesaeure；4-Hydroxy-6-methoxy-2-methyl-benzoesaeure；6-Methoxy-4-hydroxy-2-methyl-benzoesaeure; Isoeverninsaeure；4-Hydroxy-2-methoxy-6-methyl-benzoesaeure；Orsellinsaeure-6-methylaether；Isoeverninsaeure；Isoverninsaeure；4-Oxy-6-methoxy-2-methyl-benzoesaeure
• CAS: 3733-95-7
• 化学式: C₉H₁₀O₄
• 分子量: 182.176
• InChiKey: HKYUPCAKFRQXJI-UHFFFAOYSA-N

物化性质

• 熔点：
  170 °C
• 沸点：
  379.0±42.0 °C(Predicted)
• 密度：
  1.295±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2918990090

反应信息

• 作为产物：
  描述：

  甲基4-羟基-2-甲氧基-6-甲基-苯甲酸酯 在 氢氧化钾 作用下， 生成 4-羟基-2-甲氧基-6-甲基-苯甲酸
  参考文献：
  名称：

  Optimism, distress, and immunologic status in HIV-infected gay men following hurricane andrew

  摘要：

  This study investigated how dispositional optimism relates to psychological and immunologic status in 40 HIV-infected gay men residing in areas of South Florida hard hit by Hurricane Andrew. In the months following the storm, participants' levers of psychological distress (hurricane-related and overall distress) and antibody titers to several herpesviruses (Herpes Simplex Virus-2, Epstein-Barr Virus [EBV], Cytomegalovirus, and Human Herpes Virus-6 [HHV-6]) were measured. Overall, participants had elevated mean levels of hurricane-specific and general distress. Higher levels of optimism were related to lower levels of depression, overall distress, and hurricane-specific posttraumatic stress disorder symptoms. After controlling for nonspecific polyclonal B cell activation, greater optimism was also associated with lower levels of circulating antibodies to EBV and HHV-6, suggesting better cellular immunologic control over these viruses among optimists. Regression analyses showed that the relation between optimism and lower EBV titers was partially mediated by the lower depression levels experienced by optimists.

  DOI：

  10.1207/s15327558ijbm0702_5

文献信息

• Antarvedisides A-B from Manglicolous Lichen Dirinaria consimilis (Stirton) and their Pharmacological Profile
  作者：Vinay Bharadwaj Tatipamula、Girija Sastry Vedula、A.V.S. Sastry

  DOI：10.14233/ajchem.2019.21734

  日期：2019.3

  The chemical examination of acetone extract of Dirinaria consimilis resulted in isolation of six depsides of which two novel metabolites namely antarvediside A (1) and antarvediside B (2) and four known metabolites i.e. sekikaic acid (3), atranorin (4), divaricatic acid (5) and 2’-O-methyl divaricatic acid (6). From the pharmacological screening of the isolates (1-6), it was found that 1 and 2 exhibited better inhibition of ABTS and superoxide free radicals than that of the standard and compound 4 showed significant inhibition of protein denaturation with IC50 value of 390 mg/mL with respect to indomethacin with 110 mg/mL. From the SRB assay results, the better IC50 values was determined by compound 2 of 10.5, 11.50 and 12.50 μg/mL on HeLa, MCF-7 and FADU cancer cell lines, respectively. Thus, the outcomes revealed that the D. consimilis is a new source to treat free radicals, inflammation and cancer.

  Dirinaria consimilis的丙酮提取物的化学检验结果表明，分离出六种脱氧聚酮类化合物，其中包括两种新代谢物antarvediside A（1）和antarvediside B（2），以及四种已知代谢物，即sekikaic酸（3）、atranorin（4）、divaricatic酸（5）和2'-O-甲基divaricatic酸（6）。从所分离的化合物（1-6）的药理筛选中发现，1和2对ABTS和超氧自由基的抑制作用优于标准物质，化合物4显示出明显的蛋白变性抑制作用，IC50值为390 mg/mL，而对于110 mg/mL的吲哌酸而言，这是显著的。从SRB测定结果来看，化合物2在HeLa、MCF-7和FADU癌细胞系上的IC50值分别为10.5、11.50和12.50 μg/mL，表现出更好的抑制作用。因此，结果显示Dirinaria consimilis是一种新的来源，可用于治疗自由基、炎症和癌症。
• Asahina; Fujikawa, Chemische Berichte, 1932, vol. 65, p. 580,582
  作者：Asahina、Fujikawa

  DOI：——

  日期：——
• Experimental study of the generation of periodic internal waves by the boundary layer on a rotating disk
  作者：Yu. D. Chashechkin、Yu. V. Kistovich、Yu. S. Il'inykh

  DOI：10.1134/1.1333872

  日期：2000.11
• Fischer,E.; Hoesch, Justus Liebigs Annalen der Chemie, 1912, vol. 391, p. 368,369
  作者：Fischer,E.、Hoesch

  DOI：——

  日期：——
• Self-ordered CdSe quantum dots in ZnSe and (Zn, Mn)Se Matrices Assessed by transmission electron microscopy and photoluminescence spectroscopy
  作者：P. Möck、T. Topuria、N. D. Browning、L. Titova、M. Dobrowolska、S. Lee、J. K. Furdyna

  DOI：10.1007/bf02665867

  日期：2001.6

  Single and multilayer sheets of self-assembled CdSe [quantum dots (QDs)] were grown by means of molecular beam epitaxy in both ZnSe and (Zn0.9Mn0.1)Se matrices. Both types of structures were assessed by means of transmission electron microscopy in the scanning, high-resolution, and diffraction-contrast modes. Complementary results from wider sample areas were obtained by means of photoluminescence spectroscopy. In one of the samples analyzed, a fractional monolayer of MnSe was deposited immediately before the CdSe deposition. A second structure grown underidentical conditions, but without the MnSe fractional monolayer, was also analyzed. This comparison provides direct evidence for an enhanced size and shape homogeneity of 3D QDs caused by the presence of a tiny amount of MnSe at the interface. In the multilayer structure, we observed the co-existence of highly strained quasi-2D QDs and CdSe rich aggregates with compositional modulations on certain crystallographic planes in close proximity.