4-Ethyl-heptafluot-toluol | 70446-73-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Ethyl-heptafluot-toluol
• 英文别名: 4-Ethyl-heptafluortoluol；1-Ethyl-2,3,5,6-tetrafluoro-4-(trifluoromethyl)benzene
• CAS: 70446-73-0
• 化学式: C₉H₅F₇
• 分子量: 246.128
• InChiKey: BBXQKNCMQKUZIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  八氟甲苯 、 乙基溴化镁 以 四氢呋喃 为溶剂， 反应 24.0h， 以93%的产率得到4-Ethyl-heptafluot-toluol
  参考文献：
  名称：

  Transition-Metal-Free Synthesis of Fluorinated Arenes from Perfluorinated Arenes Coupled with Grignard Reagents

  摘要：

  A simple method to obtain organofluorine compounds from perfluorinated arenes coupled with Grignard reagents in the absence of a transition-metal catalyst was reported. In particular, the perfluorinated arenes could react not only with aryl Grignard reagents but also with alkyl Grignard reagents in moderate to good yields.

  DOI：

  10.1021/om4011609

文献信息

• HALOGENATED ESTERS OF CYCLOPROPANATED UNSATURATED FATTY ACIDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
  申请人：Blanchette Rockefeller Neurosciences Institute

  公开号：EP3567025A1

  公开（公告）日：2019-11-13

  The present disclosure describes novel PKC-ε activators chosen from halogenated esters of unsaturated fatty acids and derivatives thereof, including halogenated esters of both polyunsaturated and monunsaturated fatty acids and derivatives thereof. The disclosure further relates to compositions, kits, and methods for treatment using the halogenated esters.

  本公开描述了选自不饱和脂肪酸卤代酯及其衍生物（包括多不饱和和单不饱和脂肪酸卤代酯及其衍生物）的新型 PKC-ε 激活剂。本公开还涉及使用卤代酯进行治疗的组合物、试剂盒和方法。
• 18F-SUBSTITUTED ESTERS OF CYCLOPROPANATED UNSATURATED FATTY ACIDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
  申请人：Blanchette Rockefeller Neurosciences Institute

  公开号：EP4101835A1

  公开（公告）日：2022-12-14

  The present disclosure describes novel PKC-ε activators chosen from halogenated esters of unsaturated fatty acids and derivatives thereof, including halogenated esters of both polyunsaturated and monunsaturated fatty acids and derivatives thereof. The disclosure further relates to compositions, kits, and methods for treatment using the halogenated esters.

  本公开描述了选自不饱和脂肪酸卤代酯及其衍生物（包括多不饱和和单不饱和脂肪酸卤代酯及其衍生物）的新型 PKC-ε 激活剂。本公开还涉及使用卤代酯进行治疗的组合物、试剂盒和方法。
• Markovskii,L.N. et al., Journal of general chemistry of the USSR, 1979, vol. 49, p. 464 - 468
  作者：Markovskii,L.N. et al.

  DOI：——

  日期：——
• MARKOVSKIJ L. N.; FURIN G. G.; SHERMOLOVICH O. G.; YAKOBSON G. G., ZH. OBSHCH. XIMII, 1979, 49, HO 3, 531-537
  作者：MARKOVSKIJ L. N.、 FURIN G. G.、 SHERMOLOVICH O. G.、 YAKOBSON G. G.

  DOI：——

  日期：——
• US7244847B2
  申请人：——

  公开号：US7244847B2

  公开（公告）日：2007-07-17