2-[(E)-hydrazinylidenemethyl]-4-nitrophenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-[(E)-hydrazinylidenemethyl]-4-nitrophenol
• 英文别名: (1E)-2-hydroxy-5-nitro-benzaldehyde hydrazone
• 化学式: C₇H₇N₃O₃
• 分子量: 181.151
• InChiKey: UFHMSBIPLZSWJA-RUDMXATFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  二茂铁甲醛 、 2-[(E)-hydrazinylidenemethyl]-4-nitrophenol 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 以17%的产率得到2-{(E;Z)-[(2E;Z)-(ferrocenylmethylidene)hydrazinylidene]methyl}-4-nitrophenol
  参考文献：
  名称：

  Two novel unsymmetrical ferrocene based azines and their complexing abilities towards Cu(II): Spectroscopy, crystal structure, electrochemistry and DFT calculations

  摘要：

  Two new ferrocenyl-substituted unsymmetric azine ligands and their Cu(II) complexes were prepared. The redox active ferrocene-based azine ligands 1 and 2 were obtained by the condensation of 1-RE)-hydrazinylidenemethyllnaphthalen-2-o1 and 2-[(E)-hydrazinylidenemethyI]-4-nitrophenol with ferrocenecarboxaldehyde, respectively. The structures of the ligands and their Cu(II) complexes were characterized by IR, UV-Vis, NMR, X-ray, magnetic measurements and TG techniques. The 2-[(E)-hydrazinylidenemethyl]-4-nitrophenol derivative azine ligand (2) was found to be rearranged by the Cu(II) ion without water or acid/base catalyst. The redox behaviors of the ferrocene derivative compounds were investigated by cyclic voltammetry. Structural parameters and spectroscopic properties of the azine ligands (1 and 2) and the Cu(II) complex (1a) were calculated using DFT and TD-DFT/CPCM methods and the results were compared with the experimental data. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2014.12.044
• 作为产物：
  描述：

  5-硝基水杨醛 、 肼 生成 2-[(E)-hydrazinylidenemethyl]-4-nitrophenol
  参考文献：
  名称：

  JAIN M. P.; KUMAR S., TALANTA, 1979, 26, NO 9, 909-910

  摘要：

  DOI：

文献信息

• Treating an inflammatory disorder or inhibiting respiratory burst in adherent neutrophils with chemical inhibitors of neutrophil activation
  申请人：Han Hyunsil

  公开号：US20070021448A1

  公开（公告）日：2007-01-25

  The present invention relates to a method of treating an inflammatory disorder in a subject with an effective amount of compound having the general formula (I) as described in the present application, under conditions effective to treat the inflammatory disorder. The present invention also relates to a method of inhibiting respiratory burst in neutrophils without or inhibiting degranulation in or bacterial killing by the neutrophils by contacting neutrophils with the compounds described above.
• METHODS FOR SCREENING ANTIMICROBIAL AND ANTIVIRAL COMPOUNDS AND USES THEREOF
  申请人：Ausubel Frederick M.

  公开号：US20100216852A1

  公开（公告）日：2010-08-26

  The invention features compounds that have antibacterial activity, their use for the treatment of bacterial infections, screening methods that use whole animals or plant seedlings to identify compounds that inhibit a pathogen in the animal or plant, and screening methods to identify compounds that increase the lifespan of an organism.
• COMPOUNDS, COMPOSITIONS AND TREATMENTS FOR V-ATPase RELATED DISEASES
  申请人：Kartner Norbert

  公开号：US20110189306A1

  公开（公告）日：2011-08-04

  The present invention relates to therapeutic and/or prophylactic uses of hydrazide compounds and to pharmaceutical compositions containing one or more of these compounds as an active component for treating a disease or disorder requiring modulation of vacuolar (H+)-ATPases.
• US9301940B2
  申请人：——

  公开号：US9301940B2

  公开（公告）日：2016-04-05
• [EN] TREATING AN INFLAMMATORY DISORDER OR INHIBITING RESPIRATORY BURST IN ADHERENT NEUTROPHILS WITH CHEMICAL INHIBITORS OF NEUTROPHIL ACTIVATION<br/>[FR] TRAITEMENT D'UN TROUBLE INFLAMMATOIRE OU INHIBITION DE LA STIMULATION DU METABOLISME OXYDATIF DANS DES NEUTROPHILES ADHERENTS AVEC DES INHIBITEURS CHIMIQUES DE L'ACTIVATION DES NEUTROPHILES
  申请人：CORNELL RES FOUNDATION INC

  公开号：WO2005037213A2

  公开（公告）日：2005-04-28

  The present invention relates to a method of treating an inflammatory disorder in a subject with an effective amount of compound having the general formula (I) as described in the present application, under conditions effective to treat the inflammatory disorder. The present invention also relates to a method of inhibiting respiratory burst in neutrophils without inhibiting degranulation in or bacterial killing by the neutrophils by contacting neutrophils with the compounds described above.