1,9-Dibenzyl-6-(2-furyl)purin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 1,9-Dibenzyl-6-(2-furyl)purin-2-one
• 英文别名: 1,9-dibenzyl-6-(furan-2-yl)purin-2-one
• 化学式: C₂₃H₁₈N₄O₂
• 分子量: 382.422
• InChiKey: GMBMJCSYZUPRQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  61.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-碘呋喃 、 1,9-dibenzyl-1,9-dihydro-2H-purinone 在 magnesium 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 乙醚 、 苯 为溶剂， 反应 5.0h， 以66%的产率得到1,9-Dibenzyl-6-(2-furyl)purin-2-one
  参考文献：
  名称：

  Cytotoxic and Antibacterial Activity of 2-Oxopurine Derivatives

  摘要：

  Initial screening of the cytotoxic and antibacterial properties of 6-substituted 2-oxopurines and dihydro-2-oxopurines revealed that several compounds exhibited cytotoxicity against K-562 cells in the same range as the well known antileukemic drug 6-mercaptopurine. Most compounds were also tested for inhibitory effect on a Gram-positive bacterium, Lactobacillus casei, as well as the mycobacterium Mycobacterium tuberculosis. Generally the 2-oxopurines exhibited low antibacterial effect. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(01)00803-4

文献信息

• Cytotoxic and Antibacterial Activity of 2-Oxopurine Derivatives
  作者：Geir Andresen、Lise-Lotte Gundersen、Jon Nissen-Meyer、Frode Rise、Bjørn Spilsberg

  DOI：10.1016/s0960-894x(01)00803-4

  日期：2002.2

  Initial screening of the cytotoxic and antibacterial properties of 6-substituted 2-oxopurines and dihydro-2-oxopurines revealed that several compounds exhibited cytotoxicity against K-562 cells in the same range as the well known antileukemic drug 6-mercaptopurine. Most compounds were also tested for inhibitory effect on a Gram-positive bacterium, Lactobacillus casei, as well as the mycobacterium Mycobacterium tuberculosis. Generally the 2-oxopurines exhibited low antibacterial effect. (C) 2002 Published by Elsevier Science Ltd.