4-(hept-1-ynyl)pyridine | 1393897-16-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(hept-1-ynyl)pyridine
• 英文别名: 4-Hept-1-ynylpyridine
• CAS: 1393897-16-9
• 化学式: C₁₂H₁₅N
• 分子量: 173.258
• InChiKey: NFCOTGRYMUJIDJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  吡啶 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 N,N-二异丙基乙胺 作用下， 以 N-甲基吡咯烷酮 、 二氯甲烷 为溶剂， 反应 12.5h， 生成 4-(hept-1-ynyl)pyridine
  参考文献：
  名称：

  杂环鏻盐与末端炔烃的钯催化 Sonogashira 偶联

  摘要：

  开发了一种通过 C-P 键断裂将杂环鏻盐与末端炔烃有效的 Sonogashira 偶联。反应在钯催化剂、碘化铜 (I) 和N- , N-二异丙基乙胺 (DIPEA) 的存在下在N-甲基-2-吡咯烷酮 (NMP) 中在 100 °C 下顺利进行 12 h，生成相应的炔基-取代吡啶、喹啉、吡嗪和喹喔啉，产率中等至良好，底物范围广，官能团耐受性广。此外，还可以实现克级合成，该反应可应用于糖类、药物和天然产物（如雌酮、d-吡喃半乳糖、薄荷醇和布洛芬）。

  DOI：

  10.1021/acs.orglett.2c01800

文献信息

• [EN] PEST CONTROL AGENT<br/>[FR] AGENT DE LUTTE CONTRE LES ORGANISMES NUISIBLES
  申请人：ISHIHARA SANGYO KAISHA

  公开号：WO2014098259A1

  公开（公告）日：2014-06-26

  Objects of the present invention are to provide a compound which is highly active against pests, to provide a pest control agent comprising the compound, and to provide a method for controlling a pest by applying the compound. The present invention provides a 4-(arylethynyl)pyridine or a salt thereof, a pest control agent which comprises the 4-(arylethynyl)pyridine or salt thereof as an active ingredient, and a method for controlling a pest by applying the 4-(arylethynyl)pyridine or salt thereof in an effective amount.

  本发明的目的是提供一种对害虫高度活性的化合物，提供包括该化合物的杀虫剂，并提供一种通过应用该化合物来控制害虫的方法。本发明提供了一种4-(芳基乙炔基)吡啶或其盐，一种包括4-(芳基乙炔基)吡啶或其盐作为活性成分的杀虫剂，以及一种通过应用4-(芳基乙炔基)吡啶或其盐的有效量来控制害虫的方法。
• Ligand-Free and Recyclable Palladium(II) Acetate Catalyzes the Decarboxylative Cross-Coupling of Alkynyl Carboxylic Acids with Arylboronic Acids in Aqueous PEG-400
  作者：Bo-Xiao Tang、Hong Zou、Bao-Xing Xie、Hai-Qing Zhong、Yi-Hua Wang、Ying Chen、Min Hu、Qi-Qi Wen、Shi-Yao Yang

  DOI：10.1055/s-0039-1691736

  日期：2020.5

  A novel and ligand-free method was developed for the decarboxylative cross-coupling of alkynylcarboxylic acids with arylboronic acids. By using an environmentally friendly H2O–poly(ethylene glycol) (PEG-400) system as the reaction medium, a series of internal alkynes were synthesized in good yields and with remarkable selectivity. The Pd(OAc)2–H2O–PEG-400 catalytic system could be used for up to three

  开发了一种新的无配体方法，用于炔基羧酸与芳基硼酸的脱羧交叉偶联。通过使用环境友好的 H2O-聚（乙二醇）（PEG-400）体系作为反应介质，以良好的收率和显着的选择性合成了一系列内炔。Pd(OAc)2–H2O–PEG-400 催化系统最多可使用三个循环而不会损失任何活性，证明了该方法的稳健性。
• PEST CONTROL AGENT
  申请人：ISHIHARA SANGYO KAISHA, LTD.

  公开号：US20150336894A1

  公开（公告）日：2015-11-26

  Objects of the present invention are to provide a compound which is highly active against pests, to provide a pest control agent comprising the compound, and to provide a method for controlling a pest by applying the compound. The present invention provides a 4-(arylethynyl)pyridine or a salt thereof, a pest control agent which comprises the 4-(arylethynyl)pyridine or salt thereof as an active ingredient, and a method for controlling a pest by applying the 4-(arylethynyl)pyridine or salt thereof in an effective amount.

  本发明的目的是提供一种高效对抗害虫的化合物，提供包含该化合物的害虫控制剂，以及提供一种通过应用该化合物来控制害虫的方法。本发明提供了4-(芳基乙炔基)吡啶或其盐，一种包含4-(芳基乙炔基)吡啶或其盐作为活性成分的害虫控制剂，以及一种通过应用有效量的4-(芳基乙炔基)吡啶或其盐来控制害虫的方法。
• Synthesis, characterization of palladium hydroxysalen complex and its application in the coupling reaction of arylboronic acids: Mizoroki–Heck type reaction and decarboxylative couplings
  作者：Yumi Heo、Yi Young Kang、Thiruvengadam Palani、Junseong Lee、Sunwoo Lee

  DOI：10.1016/j.inoche.2012.05.013

  日期：2012.9

  (Salen-OH)Pd (1, salen-OH=N,N'-bis(3,5-di-hydroxysalicylidene)-ethylenediamine) was prepared by a simple one step reaction and fully characterized by H-1 and C-13 NMR, IR spectroscopy, and X-ray crystallography. This palladium complex showed good activities as a catalyst in the Mizoroki-Heck-type reaction and the decarboxylative coupling reaction. In the Mizoroki-Heck type reaction, arylboronic acids and alkenes were reacted at 90 degrees C for 3 h in the presence of 2.0 mol% of the palladium complex 1 and AgOAc to give the desired coupled product in good yields. In the decarboxylative coupling reactions, the desired coupled products were obtained in good yields when 0.5 mol% of the palladium complex was employed at room temperature. (C) 2012 Elsevier B.V. All rights reserved.
• NON-COMPETITIVE IMMUNOASSAY WITH BLOCKING OF UNOCCUPIED SPECIFIC BINDING SITES ON SOLID PHASE
  申请人：WALLAC OY

  公开号：EP0886754B1

  公开（公告）日：2003-01-22