C-(3-phenylfuran-2-yl)methylamine | 165736-93-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: C-(3-phenylfuran-2-yl)methylamine
• 英文别名: 3-Phenyl-2-furanmethanamine；(3-phenylfuran-2-yl)methanamine
• CAS: 165736-93-6
• 化学式: C₁₁H₁₁NO
• 分子量: 173.214
• InChiKey: GEVAGQPQKVFIJF-UHFFFAOYSA-N

物化性质

• 沸点：
  314.2±37.0 °C(Predicted)
• 密度：
  1.099±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  39.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  C-(3-phenylfuran-2-yl)methylamine 在 三氯化铝 作用下， 反应 1.0h， 生成 N-[[5-(2-chloroacetyl)-3-phenylfuran-2-yl]methyl]acetamide
  参考文献：
  名称：

  Anti-Helicobacter pylori Agents. 3. 2-[(Arylalkyl)guanidino]-4-furylthiazoles

  摘要：

  A series of 2-[(arylalkyl)guanidinol-4-[(5-acetamidomethyl)furan-2-yl]thiazoles and some 4-acetamidomethyl positional isomers were synthesized and evaluated for antimicrobial activity against Helicobacter pylori. Among the compounds that had potent antimicrobial activity (MIC < 0.1 mu g/mL), compounds 31 and 36 additionally possessed H2 antagonist and gastric antisecretory activities. Though compound 51, an analogue incorporating a methyl group onto the furan nucleus of 36, and compound 54, a positional isomer of 51, also showed potent anti-H. pylori activity, the H2 antagonism profile was eliminated from these compounds. Thus, two types of potent anti-H. pylori agents could be derived from the same scaffold.

  DOI：

  10.1021/jm9900671
• 作为产物：
  描述：

  苯基三氟甲烷磺酸酯 在 lithium aluminium tetrahydride 、 四(三苯基膦)钯 、 正丁基锂 、 硼酸三异丙酯 、 三乙胺 作用下， 以 乙醚 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 C-(3-phenylfuran-2-yl)methylamine
  参考文献：
  名称：

  Anti-Helicobacter pylori Agents. 3. 2-[(Arylalkyl)guanidino]-4-furylthiazoles

  摘要：

  A series of 2-[(arylalkyl)guanidinol-4-[(5-acetamidomethyl)furan-2-yl]thiazoles and some 4-acetamidomethyl positional isomers were synthesized and evaluated for antimicrobial activity against Helicobacter pylori. Among the compounds that had potent antimicrobial activity (MIC < 0.1 mu g/mL), compounds 31 and 36 additionally possessed H2 antagonist and gastric antisecretory activities. Though compound 51, an analogue incorporating a methyl group onto the furan nucleus of 36, and compound 54, a positional isomer of 51, also showed potent anti-H. pylori activity, the H2 antagonism profile was eliminated from these compounds. Thus, two types of potent anti-H. pylori agents could be derived from the same scaffold.

  DOI：

  10.1021/jm9900671

文献信息

• [EN] INDANE DERIVATES AS MUSCARINIC RECEPTOR AGONISTS<br/>[FR] DERIVES D'INDANE UTILISES COMME AGONISTES DU RECEPTEUR MUSCARINIQUE
  申请人：LILLY CO ELI

  公开号：WO2005009941A1

  公开（公告）日：2005-02-03

  The present invention relates to compounds of Formula I: I which are agonists of the M-1 muscarinic receptor.

  这项发明涉及到Formula I的化合物，这些化合物是M-1肌氨酸受体的激动剂。
• Indane derivates as muscarinic receptor agonists
  申请人：Eli Lilly and Company

  公开号：US07265246B2

  公开（公告）日：2007-09-04

  The present invention relates to compounds of Formula I: I which are agonists of the M-1 muscarinic receptor

  本发明涉及公式I的化合物：I，它们是M-1肌动蛋白受体的激动剂。
• INDANE DERIVATES AS MUSCARINIC RECEPTOR AGONISTS
  申请人：ELI LILLY AND COMPANY

  公开号：EP1644320B1

  公开（公告）日：2008-01-16
• US7265246B2
  申请人：——

  公开号：US7265246B2

  公开（公告）日：2007-09-04
• Anti-<i>Helicobacter pylori</i> Agents. 3. 2-[(Arylalkyl)guanidino]-4-furylthiazoles
  作者：Yousuke Katsura、Shigetaka Nishino、Mitsuko Ohno、Kazuo Sakane、Yoshimi Matsumoto、Chizu Morinaga、Hirohumi Ishikawa、Hisashi Takasugi

  DOI：10.1021/jm9900671

  日期：1999.7.1

  A series of 2-[(arylalkyl)guanidinol-4-[(5-acetamidomethyl)furan-2-yl]thiazoles and some 4-acetamidomethyl positional isomers were synthesized and evaluated for antimicrobial activity against Helicobacter pylori. Among the compounds that had potent antimicrobial activity (MIC < 0.1 mu g/mL), compounds 31 and 36 additionally possessed H2 antagonist and gastric antisecretory activities. Though compound 51, an analogue incorporating a methyl group onto the furan nucleus of 36, and compound 54, a positional isomer of 51, also showed potent anti-H. pylori activity, the H2 antagonism profile was eliminated from these compounds. Thus, two types of potent anti-H. pylori agents could be derived from the same scaffold.