6-(乙胺基)己烷-1-醇 | 42055-20-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 6-(乙胺基)己烷-1-醇
• 英文名称: N-ethyl-6-hydroxyhexylamine
• 英文别名: 6-(ethylamino)-1-hexanol；6-(ethylamino)hexan-1-ol；6-Ethylamino-1-hexanol；Ethylamino-6-hexanol-1
• CAS: 42055-20-9
• 化学式: C₈H₁₉NO
• 分子量: 145.245
• InChiKey: GKTZKHBCHBKGSC-UHFFFAOYSA-N

物化性质

• 沸点：
  95 °C(Press: 1.5 Torr)
• 密度：
  0.870±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-(乙胺基)己烷-1-醇 在 硝酸 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 24.0h， 生成 7-chloro-4-{[3-({ethyl[6-(nitrooxy)hexyl]ammonio}methyl)-4-hydroxyphenyl]amino}quinoline
  参考文献：
  名称：

  Amodiaquine analogues containing NO-donor substructures: Synthesis and their preliminary evaluation as potential tools in the treatment of cerebral malaria

  摘要：

  The synthesis and physico-chemical properties of novel compounds obtained by conjugation of amodiaquine with moieties containing either furoxan or nitrooxy NO-donor substructures are described. The synthesised compounds were tested in vitro against both the chloroquine sensitive, 010 and the chloroquine resistant, W-2 strains of Plasmodium falciparum (P falciparum). Most of the compounds showed an antiplasmodial activity comparable to that of the parent drug. By comparing the activities of simple related structures devoid of the ability to release NO, it appears that the contribution of NO to the antiplasmodial action in vitro is marginal. All the compounds were able to relax rat aorta strips with a NO-dependent mechanism, thus showing their capacity to release NO in the vessels. A preliminary in vivo study using Plasmodium berghei ANKA-infected mice showed a trend for prolonged survival of mice with cerebral malaria treated with compound 40, which is potent and fast amodiaquine-derived NO-donor, when compared with amodiaquine alone or with compound 31, a milder NO-donor. The two compounds showed in vivo antiplasmodial activity similar to that of amodiaquine. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.02.029
• 作为产物：
  描述：

  6-氯-1-己醇 、 乙胺 以57%的产率得到6-(乙胺基)己烷-1-醇
  参考文献：
  名称：

  Analogs of 8-[[6-(diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline as candidate antileishmanial agents

  摘要：

  8-[[6-(Diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline (I) has been shown to be highly effective against Leishmania donovani in hamsters, being approximately 475 times as active as the standard meglumine antimoniate. Several nuclear and side-chain analogues of I have been prepared in an attempt to further enhance the antileishmanial activity of this class of compounds. The compounds were tested against L. donovani in the golden hamster. Although several analogues had meglumine antimoniate indexes in excess of 300, none was superior to the model compound.

  DOI：

  10.1021/jm00183a004

文献信息

• 12-EPI PLEUROMUTILINS
  申请人：NABRIVA THERAPEUTICS AG

  公开号：US20160332963A1

  公开（公告）日：2016-11-17

  A compound selected from 14-O-[((Alkyl-, cycloalkyl-, heterocycloalkyl-, heteoroaryl-, or aryl)-sulfanyl)-acetyl]-12-epi-mutilins, or 14-O-[((Alkyl-, cycloalkyl-, heterocycloalkyl-, heteoroaryl-, or aryl)-oxy)-acetyl]-12-epi-mutilins, wherein 12-epi-mutilin is characterized in that the mutilin ring at position 12 is substituted by two substituents, the first substituent at position 12 of the mutilin ring is a methyl group which methyl group has the inverse stereochemistry compared with the stereochemistry of the methyl group at position 12 of the naturally occurring pleuromutilin ring, the second substituent at position 12 of the mutilin ring is a hydrocarbon group comprising at least one nitrogen atom and all other substituents of the mutilin ring having the same stereochemistry compared with the stereochemistry of the substituents at the corresponding positions in the naturally occurring pleuromutilin ring; optionally in the form of a salt and/or solvate, wherein the naturally occurring pleuromutilin is of formula processes for the preparation of such compounds and their use as pharmaceuticals.

  从14-O-[((烷基、环烷基、杂环烷基、杂环芳基或芳基)-硫基)-乙酰基]-12-epi-木替林，或14-O-[((烷基、环烷基、杂环烷基、杂环芳基或芳基)-氧基)-乙酰基]-12-epi-木替林中选择的一种化合物，其中12-epi-木替林的特征在于木替林环在位置12被两个取代基取代，木替林环在位置12的第一个取代基是一个甲基基团，该甲基基团的立体化学与天然存在的普鲁木替林环在位置12的甲基基团的立体化学相反，木替林环在位置12的第二个取代基是一个含有至少一个氮原子的碳氢基团，木替林环的所有其他取代基与天然存在的普鲁木替林环中相应位置的取代基的立体化学相同；可选地以盐和/或溶剂的形式存在，其中天然存在的普鲁木替林的化学式为 制备这类化合物的方法以及它们作为药物的用途。
• Selective N-alkylation of amines using nitriles under hydrogenation conditions: facile synthesis of secondary and tertiary amines
  作者：Takashi Ikawa、Yuki Fujita、Tomoteru Mizusaki、Sae Betsuin、Haruki Takamatsu、Tomohiro Maegawa、Yasunari Monguchi、Hironao Sajiki

  DOI：10.1039/c1ob06303k

  日期：——

  the one-pot hydrogenation of the nitro group and the reductive alkylation of the amines. While aliphatic amines were effectively converted to the corresponding tertiary amines under Pd/C-catalyzed conditions, Rh/C was a highly effective catalyst for the N-monoalkylation of aliphatic primary amines without over-alkylation to the tertiary amines. Furthermore, the combination of the Rh/C-catalyzed N-monoalkylation

  发现腈是在催化氢化条件下用于胺的选择性N-烷基化的高效烷基化试剂。对于芳族伯胺，相应的仲胺是在以下条件下有选择地获得的：钯/ C催化的氢化条件。尽管使用电子贫乏的芳族胺或庞大的腈显示出对还原烷基化反应的较低反应性，但添加NH 4 OAc增强了反应活性，从而以优异的产率获得了芳族仲胺。在相同的反应条件下，芳族硝基化合物代替芳族伯胺可以通过多胺反应直接转化为仲胺，该反应涉及硝基的一锅加氢和胺的还原烷基化。脂族胺在以下条件下有效地转化为相应的叔胺钯/ C催化的条件， 铑/ C是用于脂族伯胺的N-单烷基化而不会过度烷基化成叔胺的高效催化剂。此外，铑/ C催化的脂肪族伯胺的N-单烷基化反应及其他钯所得仲脂族胺的/ C催化烷基化可以选择性地制备具有三个不同烷基的脂族叔胺。根据机理研究，似乎可以合理地得出以下结论：在反应的第一步中，在胺发生亲核攻击之前，腈被还原为醛亚胺。
• [EN] NOVEL AGENTS FOR REWORKABLE EPOXY RESINS<br/>[FR] NOUVEAUX AGENTS POUR DES RÉSINES ÉPOXY POUVANT ÊTRE REMANIÉES
  申请人：WUXI ADESSONANOTECH CO LTD

  公开号：WO2012071896A1

  公开（公告）日：2012-06-07

  Compounds of formula I, uses as crosslinking agents or curing agents thereof, and resins obtained by using the compounds as crosslinking agents.

  公式I的化合物，用作交联剂或固化剂，以及使用该化合物作为交联剂获得的树脂。
• CURABLE AQUEOUS COMPOSITION
  申请人：Kobata Masami

  公开号：US20100230291A1

  公开（公告）日：2010-09-16

  The present invention provides an aqueous curable composition comprising (A) a compound comprising all or some primary amino groups and/or secondary amino groups optionally neutralized with a Brønsted acid, and (B) a crosslinking agent, the crosslinking agent being a compound having an (N-alkyl-N-(2-acylacyl)amino)alkyloxycarbonylamino group represented by General Formula (I) wherein R 1 , R 2 and R 3 are each independently a hydrogen atom or C 1-7 alkyl group, R 4 and R 5 are each independently a hydrogen atom or C 1-16 organic group, and Y is a straight C 1-6 alkylene group optionally substituted with a C 1-6 organic group as a substituent.

  本发明提供一种水性固化组合物，包括（A）化合物，其包含全部或部分原始氨基和/或次要氨基，可选择用Brønsted酸中和，以及（B）交联剂，所述交联剂是一种具有（N-烷基-N-（2-酰基酰基）氨基）烷氧羰基氨基基团的化合物，其通式表示为（I），其中R1、R2和R3各自独立地为氢原子或C1-7烷基，R4和R5各自独立地为氢原子或C1-16有机基团，Y是一种直链的C1-6烷基，可选择用C1-6有机基团作为取代基。
• COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING PNEUMOVIRUS INFECTION AND ASSOCIATED DISEASES
  申请人：Nitz Theodore J.

  公开号：US20120183498A1

  公开（公告）日：2012-07-19

  Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infection.

  本发明提供了用于预防和治疗由Pneumovirinae亚科Paramyxoviridae病毒引起的感染以及与此类感染相关的疾病的化合物、组合物和方法。