-1,4-Dibrom-2-methyl-2-buten | 16526-18-4

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机溴化物
• 英文名称: -1,4-Dibrom-2-methyl-2-buten
• 英文别名: (Z)-1,4-dibromo-2-methylbut-2-ene；(Z)-1,4-dibromo-2-methylbutene；1,4-dibromo-2-methylbut-2-ene；(Z)-1,4-dibromo-2-methyl-but-2-ene；1,4-dibromo-2-methyl-but-2c-ene；1,4-Dibrom-2-methyl-but-2c-en；(Z)-1,4-Dibrom-2-methyl-2-buten
• CAS: 16526-18-4
• 化学式: C₅H₈Br₂
• 分子量: 227.927
• InChiKey: HICPKHPJQJZCFP-DJWKRKHSSA-N

物化性质

• 沸点：
  79-81 °C(Press: 10 Torr)
• 密度：
  1.741±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  -1,4-Dibrom-2-methyl-2-buten 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Petrow, Zhurnal Obshchei Khimii, 1943, vol. 13, p. 741,748

  摘要：

  DOI：
• 作为产物：
  描述：

  3,4-dibromo-2-methyl-but-1-ene 生成 -1,4-Dibrom-2-methyl-2-buten
  参考文献：
  名称：

  Petrow, Zhurnal Obshchei Khimii, 1943, vol. 13, p. 741,748

  摘要：

  DOI：

文献信息

• β- and γ-Disubstituted Olefins: Substrates for Copper-Catalyzed Asymmetric Allylic Substitution
  作者：Caroline A. Falciola、Karine Tissot-Croset、Hugo Reyneri、Alexandre Alexakis

  DOI：10.1002/adsc.200800086

  日期：2008.5.5

  The copper-catalyzed asymmetric allylic alkylation has shown through many examples that it is a powerful means to generate stereogenic centers with mono β- and γ-substituted olefinic substrates. However, little has been reported about more substituted olefinic patterns, such as β-disubstituted allylic electrophiles. In this paper, we show that a simple procedure using easily accessible Grignard reagents

  铜催化的不对称烯丙基烷基化通过许多实例表明，它是用单β-和γ-取代的烯烃底物生成立体异构中心的有效手段。然而，关于更多取代的烯烃图案，例如β-二取代的烯丙基亲电试剂，几乎没有报道。在本文中，我们表明，使用容易获得的格氏试剂和低至3 mol％的铜/配体的简单程序可以促进高至近乎完美的对映选择性（高达> 99％ee），并且在很宽的范围内具有很好的γ选择性一组脂族或芳族β-二取代底物。
• Synthesis of 1<i>H</i>-Cyclopropa[<i>b</i>]naphthalenes<i>via</i>Trapping of<i>o</i>-Benzoquinodimethanes
  作者：Paul Müller、Domingo Rodriguez

  DOI：10.1002/hlca.19850680423

  日期：1985.6.26

  1H-Cyclopropa[b]naphthalene (10a) and 3-methyl or dimethyl derivatives have been synthesized by interception of appropriately substituted o-quinodimethanes 3 with 1-bromo-2-chlorocyclopropene 5, and subsequent dehydrohalogenation of the adducts. The o-quinodimethane derivatives 3 in turn were obtained from the diynes 7via base-induced isomerization to bisallenes 8 and thermal electrocyclic ring closure

  通过用1-溴-2-氯环丙烯5拦截适当取代的邻喹啉甲烷3，然后加合物脱氢卤化，合成了1 H-环丙烷[ b ]萘（10a）和3-甲基或二甲基衍生物。所述Ô -quinodimethane衍生物3依次从该二炔得到7通过碱诱导的异构化，以bisallenes 8和热电环化环合。
• Quinkert, Gerhard; Schmalz, Hans-Guenther; Walzer, Egon, Liebigs Annalen der Chemie, 1988, p. 283 - 316
  作者：Quinkert, Gerhard、Schmalz, Hans-Guenther、Walzer, Egon、Gross, Stefan、Kowalczyk-Przewloka, Teresa、et al.

  DOI：——

  日期：——
• Fast Assembly and High-Throughput Screening of Structure and Antioxidant Relationship of Carotenoids
  作者：Dahye Kim、Gaosheng Shi、YunJi Kim、Sangho Koo

  DOI：10.1021/acs.orglett.8b03915

  日期：2019.2.1

  C-20 heptaenyl diphosphonate 4 was prepared for one-pot synthesis of carotenoids 1. Olefination with various aromatic aldehydes allowed fast assembly of the corresponding carotenoids. The SAR of carotenoids was investigated by high-throughput screening of ABTS and DPPH assays and their hierarchical clustering analysis. Antioxidant activity of carotenoids increased with the number of electron-donating substituents. Carotene la with multiple electron-donating substituents was most proficient, which showed better radical scavenging activities than beta-carotene and lycopene.
• Cuthbertson, Matthew J.; Rizzardo, Ezio; Solomon, David H., Australian Journal of Chemistry, 1983, vol. 36, # 10, p. 1957 - 1973
  作者：Cuthbertson, Matthew J.、Rizzardo, Ezio、Solomon, David H.

  DOI：——

  日期：——