1-<(2-aminoethylamino)>-5-<(2-dimethylaminoethyl)amino>-anthraquinone | 123296-32-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 1-<(2-aminoethylamino)>-5-<(2-dimethylaminoethyl)amino>-anthraquinone
• 英文别名: 1-[(2-aminoethylamino)]-5-[(2-dimethylaminoethyl)amino]-anthraquinone；1-(2-Aminoethylamino)-5-[2-(dimethylamino)ethylamino]anthracene-9,10-dione
• CAS: 123296-32-2
• 化学式: C₂₀H₂₄N₄O₂
• 分子量: 352.436
• InChiKey: YEPLNOKJLGJLTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  87.5
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1-氯蒽醌 以 甲苯 为溶剂， 反应 36.17h， 生成 1-<(2-aminoethylamino)>-5-<(2-dimethylaminoethyl)amino>-anthraquinone
  参考文献：
  名称：

  Synthesis of aminoanthraquinone derivatives and their in vitro evaluation as potential anti-cancer drugs

  摘要：

  DOI：

  10.1016/0223-5234(89)90159-1

文献信息

• SUBSTITUTED ANTHRAQUINONE DYES FOR CELLULAR STAINS AND ENZYME DETECTION
  申请人：Mao Fei

  公开号：US20120252063A1

  公开（公告）日：2012-10-04

  The invention discloses new substituted anthraquinone dyes that may be useful as cellular stains. In some aspect of the invention, the nuclear stains are useful for staining the nuclei of dead or fixed cells. Another aspect of the invention relates to substituted anthraquinone dyes comprising an enzyme substrate moiety that is transformable or cleavable by an enzyme such that the transformation or cleavage of the substrate moiety causes a detectable change in the functionality or spectral properties of the dye.

  本发明公开了新的取代蒽醌染料，可能用作细胞染料。在发明的某些方面，核染料可用于染色死亡或固定细胞的细胞核。发明的另一方面涉及包含可由酶转化或切割的酶底物部分的取代蒽醌染料，使得底物部分的转化或切割导致染料的功能性或光谱性质发生可检测的变化。
• [EN] METHOD OF ANALYSING A CELL OR OTHER BIOLOGICAL MATERIAL CONTAINING A NUCLEIC ACID<br/>[FR] PROCÉDÉ D'ANALYSE D'UNE CELLULE OU D'UN AUTRE MATÉRIEL BIOLOGIQUE CONTENANT UN ACIDE NUCLÉIQUE
  申请人：BIOSTATUS LTD

  公开号：WO2011124927A1

  公开（公告）日：2011-10-13

  According to the invention there is provided a compound of Formula (I) in which: A is a C2-8 alkylene group; R1, R2, R3, and R4 are independently selected from hydrogen, C1-4 alkyl, C2-4 dihydroxyalkyl in which the carbon atom attached to the nitrogen atom does not carry a hydroxyl group and no carbon atom is substituted by two hydroxyl groups, or R2 and R3 together form a C2-6 alkylene group which with the nitrogen atom to which R2 and R3 are attached forms a heterocyclic ring; X1, X2 and X3 are independently selected from hydrogen, hydroxyl, NR1-A- NR2R3R4+ (Zm-)1/m, halogeno amino, C1-4 alkoxy or C2-8 alkanoyloxy; and (Zm-)1/m is an anion of charge m; or a derivative in which the group NR1 is quaternarised.

  根据发明提供了一种式子为（I）的化合物，其中：A是C2-8烷基；R1、R2、R3和R4独立地选自氢、C1-4烷基、C2-4二羟基烷基（其中连接氮原子的碳原子不带有羟基，且没有碳原子被两个羟基取代），或者R2和R3共同形成一个C2-6烷基，该烷基与R2和R3连接的氮原子形成一个杂环环；X1、X2和X3独立地选自氢、羟基、NR1-A-NR2R3R4+（Zm-）1/m、卤代氨基、C1-4烷氧基或C2-8烷酰氧基；（Zm-）1/m是带电荷m的阴离子；或者是基团NR1被季铵化的衍生物。
• KATZHENDLER, JEHOSHUA;GEAN, KERIA-FIORELLA;BAR-AD, GIDON;TASHMA, ZEEV;BEN+, EUR. J. MED. CHEM., 24,(1989) N, C. 23-30
  作者：KATZHENDLER, JEHOSHUA、GEAN, KERIA-FIORELLA、BAR-AD, GIDON、TASHMA, ZEEV、BEN+

  DOI：——

  日期：——
• METHOD OF ANALYSING A CELL OR OTHER BIOLOGICAL MATERIAL CONTAINING A NUCLEIC ACID
  申请人：Biostatus Limited

  公开号：EP2556047B1

  公开（公告）日：2018-06-06
• METHOD OF ANALYSING A CELL OR OTHER BIOLOGICAL MATERIAL CONTAINING NUCLEIC ACID
  申请人：Biostatus Limited

  公开号：EP3366667B1

  公开（公告）日：2021-02-17