(E)-N-[2-(4-Methylphenyl)ethenyl]morpholine | 72680-70-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-N-[2-(4-Methylphenyl)ethenyl]morpholine
• 英文别名: 1-[(E)-2-(4-methylphenyl)ethenyl]morpholine；(E)-1-(p-methylphenyl)-2-morpholino-ethene；4-(4-Methyl-α-styryl)-morpholin；4-(4-methyl-styryl)-morpholine；4-[(E)-2-(4-methylphenyl)ethenyl]morpholine
• CAS: 72680-70-7
• 化学式: C₁₃H₁₇NO
• 分子量: 203.284
• InChiKey: BJLNWOGBWWIFTD-VOTSOKGWSA-N

物化性质

• 熔点：
  68-70 °C(Solv: methanol (67-56-1); water (7732-18-5))
• 沸点：
  338.3±41.0 °C(Predicted)
• 密度：
  1.111±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-N-[2-(4-Methylphenyl)ethenyl]morpholine 在 盐酸 、 二异丁基氢化铝 、 三乙胺 作用下， 以 1,4-二氧六环 、 氯仿 、 水 、 甲苯 为溶剂， 反应 6.0h， 生成 [1-(4-fluorophenyl)-4-(4-methylphenyl)pyrazol-3-yl]methanol
  参考文献：
  名称：

  Biere; Schroder; Ahrens, European Journal of Medicinal Chemistry, 1982, vol. 17, # 1, p. 27 - 34

  摘要：

  DOI：
• 作为产物：
  描述：

  4-[(二苯基磷酰)甲基]吗啉 在 potassium hydride 作用下， 生成 (E)-N-[2-(4-Methylphenyl)ethenyl]morpholine
  参考文献：
  名称：

  通过霍纳-维蒂希反应进行烯胺合成

  摘要：

  芳族和脂族醛可通过与-吗啉代甲基二苯基膦氧化物（）的Horner-Wittig反应转化为它们的同源烯胺。

  DOI：

  10.1016/s0040-4039(01)86312-7

文献信息

• ν-Triazolines. Part 42. Study on the reactivity of 4,5-dihydro-1-(6-methyl-2-oxo-2H-pyran-4-yl)-5-morpholino-ν-triazoles. Synthetic approach to pyrano[4,3-b]pyrrol-4(1H)-ones
  作者：Emanuela Erba、Donato Pocar、Pasqualina Trimarco

  DOI：10.1039/b008531f

  日期：——

  Pyrolysis of 4-aryl-5-morpholino-4,5-dihydrotriazoles 3 affords two products: pyrano[4,3-b]pyrrol-4(1H)-ones 4 and arylacetamidines 5. The reaction mechanism of this transformation is discussed and reaction conditions optimized to enhance the formation of pyrrole-fused pyran-2-one derivatives 4. 2-Aminoaziridines are considered to be key intermediates in this transformation.

  4-芳基-5-吗啉代-4,5-二氢三唑 3 的热解得到两种产物：吡喃并[4,3-b]吡咯-4(1H)-酮 4 和芳基乙脒 5。讨论了该转化的反应机理并优化反应条件以增强吡咯稠合吡喃-2-酮衍生物4的形成。2-氨基氮丙啶被认为是该转化中的关键中间体。
• The First Rhodium-Catalyzed Anti-Markovnikov Hydroamination: Studies on Hydroamination and Oxidative Amination of Aromatic Olefins
  作者：M. Beller、H. Trauthwein、M. Eichberger、C. Breindl、J. Herwig、T. E. Müller、O. R. Thiel

  DOI：10.1002/(sici)1521-3765(19990401)5:4<1306::aid-chem1306>3.0.co;2-4

  日期：1999.4.1

  The first transition-metal-catalyzed regiospecific anti-Markovnikov hydroamination of aromatic olefins is reported. Styrene and substituted styrenes react with secondary aliphatic amines, especially morpholine and N-arylpiperazines, in the presence of cationic rhodium complexes to give 2-aminoethenylbenzene and 2-aminoethylbenzene derivatives. Cationic [Rh(cod)(2)]+BF4- and various phosphines (1:2-mixture) were employed as in situ catalysts. According to labeling experiments, there is no evidence that the hydroamination is a consecutive hydrogenation of a previously formed enamine. Hydroamination with simple secondary amines, for example piperidine, can also be achieved by the use of a higher olefin concentration and higher reaction temperatures than those given in previously published reaction procedures. Kinetic investigations of the major reaction pathway reveal that the reaction rate of the oxidative amination and the hydroamination is dependent on the styrene and on the catalyst concentration, and independent of the amine concentration. Experiments that employed deuterium-labeled amines (N-D) provided evidence that the mechanism involves an amine-activating pathway, The substituents on the styrene, the phosphine ligand, and the solvent influence the yield of the aminations and the enamine:alkylamine ratio.
• Rhodium-Catalyzed Anti-Markovnikov Hydroamination of Vinylarenes
  作者：Masaru Utsunomiya、Ryoichi Kuwano、Motoi Kawatsura、John F. Hartwig

  DOI：10.1021/ja0293608

  日期：2003.5.1

  The transition metal-catalyzed anti-Markovnikov hydroamination of unactivated vinylarenes with a rhodium complex of DPEphos is reported. The reaction of electron-neutral or electron-rich vinylarenes with a variety of secondary amines in the presence of catalyst forms the products from anti-Markovnikov hydroamination in high yields. Reactions of morpholine, N-phenylpiperazine, N-Boc-piperazine, piperidine, 2,5-dimethylmorpholine, and perhydroisoquinoline reacted with styrene to form the amine product in 51-71% yield. Reactions of a variety of vinylarenes with morpholine generated amine as the major product. Reactions of morpholine with electron-poor vinylarenes gave lower amine:enamine ratios than reactions of electron-rich vinylarenes at the same concentration of vinylarene, but conditions were developed with lower concentrations of electron-poor vinylarene to maintain formation of the amine as the major product. Reactions of dimethylamine with vinylarenes were fast and formed amine as the major product. Mechanistic studies on the hydroamination process showed that the amine:enamine ratio was lower for reactions conducted with higher concentrations of vinylarene and that one vinylarene influences the selectivity for reaction of another. A mechanism proceeding through a metallacyclic intermediate that opens in the presence of a second vinylarene accounts for these and other mechanistic observations.
• Synthesis of celecoxib via 1,3-dipolar cycloaddition
  作者：Lynette M. Oh

  DOI：10.1016/j.tetlet.2006.08.138

  日期：2006.11

  A regioselective 1,3-dipolar cycloaddition reaction between a nitrile imine and an enamine is described for the preparation of celecoxib. Nitrile imines are generated in situ from the corresponding hydrazonoyl benzenesulfonates. (c) 2006 Elsevier Ltd. All rights reserved.
• Broekhof, N. L. J. M.; Gen, A. van der, Recueil des Travaux Chimiques des Pays-Bas, 1984, vol. 103, # 11, p. 305 - 312
  作者：Broekhof, N. L. J. M.、Gen, A. van der

  DOI：——

  日期：——