(2,4,6-三溴苯基)丙酸酯 | 76461-14-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 中文名称: (2,4,6-三溴苯基)丙酸酯
• 英文名称: tribromophenyl propanoate
• 英文别名: propionic acid-(2,4,6-tribromo-phenyl ester)；Propionsaeure-(2,4,6-tribrom-phenylester)；(2.4.6-Tribrom-phenyl)-propionat；2,4,6-tribromophenyl propionate；2,4,6-Tribromophenylpropionat；(2,4,6-tribromophenyl) propanoate
• CAS: 76461-14-8
• 化学式: C₉H₇Br₃O₂
• 分子量: 386.865
• InChiKey: AYPLUWLTDGVVIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2915509000

反应信息

• 作为产物：
  描述：

  丙酰氯 、 三溴苯酚 生成 (2,4,6-三溴苯基)丙酸酯
  参考文献：
  名称：

  RAPD- andactAGene-Typing ofListeria monocytogenesIsolates of Human Listeriosis, the Intestinal Contents of Cows and Beef

  摘要：

  AbstractSeventy‐five L. monocytogenes isolates of human listeriosis, the intestinal contents of cows and beef were divided into 5 major clusters, 17 sub‐clusters and 28 minor clusters by typing using random amplification of polymorphic DNA (RAPD). According to their major RAPD category, L. monocytogenes isolates serotyped as 1/2b and 4b were distinguished from L. monocytogenes isolates of serovars 1/2a and 1/2c. Moreover serovar 4b was distinguished from serovar 1/2b by a difference in the RAPD sub‐cluster category. All L. monocytogenes were found to possess either actA gene Type I or n, and only one actA gene type was detected in each RAPD minor cluster. actA gene Type II was observed in 32.0%, 38.5 % and 18.9% of isolates from humans, cows and beef, respectively, and was detected more frequently in serovar 4b (46.9%) than in serovars 1/2a (22.2%), 1/2b (7.7%) and 1/2c (0.0%). Twenty (80%) of 25 human isolates fell within three minor RAPD types (II‐d (16%), V‐p‐1 (36%), V‐p‐2 (28%)). Two isolates from humans and beef were found to have the same RAPD type (Type IV‐k‐1), actA gene type (Type I) and serovar (1/2b). Our results suggest that only a few genotypes of L. monocytogenes are predominant in human listeriosis in Japan, although the human isolates were collected over a broad span of time and a wide geographical range. Our results also suggest that RAPD‐, actA gene‐ and sero‐typing can be useful for epidemiological analysis.

  DOI：

  10.1111/j.1348-0421.2001.tb01280.x

文献信息

• Method for enhancing folding and transport of misfolded glucocerebrosidase
  申请人：The Hospital for Sick Children

  公开号：US10028922B2

  公开（公告）日：2018-07-24

  Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.

  本文描述了治疗晚发型戈谢病的治疗组合物和方法。这些组合物包括对突变形式的β-葡糖脑苷脂具有药理伴侣活性的化合物。治疗方法包括向有需要的受试者提供治疗有效量的此类组合物。
• Method of treating gaucher disease
  申请人：Mahuran Don J.

  公开号：US20090075960A1

  公开（公告）日：2009-03-19

  Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.
• METHOD OF TREATING GAUCHER DISEASE
  申请人：Mahuran Don J

  公开号：US20120021487A1

  公开（公告）日：2012-01-26

  Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.
• METHOD OF TREATING LYSOSOMAL STORAGE DISORDERS
  申请人：The Hospital for Sick Children

  公开号：US20140235713A1

  公开（公告）日：2014-08-21

  Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.
• METHOD FOR ENHANCING FOLDING AND TRANSPORT OF MISFOLDED GLUCOCEREBROSIDASE
  申请人：The Hospital for Sick Children

  公开号：US20140249233A1

  公开（公告）日：2014-09-04

  Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.