2-Methyl-3-ethoxycarbonyl-4-(4-methoxyphenyl)-5-oxo-4,5-dihydro-1H-indeno<1,2-b>pyridine | 90786-99-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: 2-Methyl-3-ethoxycarbonyl-4-(4-methoxyphenyl)-5-oxo-4,5-dihydro-1H-indeno<1,2-b>pyridine
• 英文别名: 3-Ethoxycarbonyl-2-methyl-4-(4-methoxyphenyl)-5-oxo-4,5-dihydro-1H-indeno<1,2-b>pyridine；ethyl 4-(4-methoxyphenyl)-2-methyl-5-oxo-4,5-dihydro-1H-indeno[1,2-b]pyridine-3-carboxylate；2-methyl-4-(4-methoxyphenyl)-5-oxo-4,5-dihydro-1H-indeno-[1,2-b]pyridine-3-carboxylic acid ethyl ester；4-(4-methoxy-phenyl)-2-methyl-5-oxo-4,5-dihydro-1H-indeno[1,2-b]pyridine-3-carboxylic acid ethyl ester；4-(4-Methoxy-phenyl)-2-methyl-5-oxo-4,5-dihydro-1H-indeno[1,2-b]pyridin-3-carbonsaeure-aethylester；ethyl 4-(4-methoxyphenyl)-2-methyl-5-oxo-1,4-dihydroindeno[1,2-b]pyridine-3-carboxylate
• CAS: 90786-99-5
• 化学式: C₂₃H₂₁NO₄
• 分子量: 375.424
• InChiKey: JCMXJBLZNIDARV-UHFFFAOYSA-N

物化性质

• 熔点：
  253 °C
• 沸点：
  563.2±50.0 °C(Predicted)
• 密度：
  1.28±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-Methyl-3-ethoxycarbonyl-4-(4-methoxyphenyl)-5-oxo-4,5-dihydro-1H-indeno<1,2-b>pyridine 、 碘甲烷 以22%的产率得到
  参考文献：
  名称：

  LUSIS, V. K.;MUTSENIETSE, D. X.;ZANDERSONS, A. Z.;MAZHEJKA, I. B.;DUBUR, +, XIMIYA GETEROTSIKL. SOEDIN., 1984, N 3, 393-398

  摘要：

  DOI：
• 作为产物：
  描述：

  1,3-茚满二酮 、 乙酰乙酸乙酯 、 4-甲氧基苯甲醛 在 ammonium acetate 作用下， 以 neat (no solvent) 为溶剂， 反应 0.25h， 以91%的产率得到2-Methyl-3-ethoxycarbonyl-4-(4-methoxyphenyl)-5-oxo-4,5-dihydro-1H-indeno<1,2-b>pyridine
  参考文献：
  名称：

  用氨基磺酸氨基胺（PAMAM）树枝状聚合物功能化的磁性Fe3O4@SiO2核壳纳米颗粒用于多组分合成多氢喹啉和二氢-1H-茚并[1,2-b]吡啶

  摘要：

  (2021)。用氨基磺酸胺（PAMAM）树枝状聚合物功能化的磁性 Fe3O4@SiO2 核壳纳米颗粒，用于多组分合成多氢喹啉和二氢-1H-茚并 [1,2-b] 吡啶。国际有机制剂和程序：卷。53，第 5 期，第 498-508 页。

  DOI：

  10.1080/00304948.2021.1957644

文献信息

• Multicomponent one-pot solvent-free synthesis of functionalized unsymmetrical dihydro-1H-indeno[1,2-b]pyridines
  作者：Subhasis Samai、Ganesh Chandra Nandi、Ram Kumar、M.S. Singh

  DOI：10.1016/j.tetlet.2009.10.022

  日期：2009.12

  A simple and efficient synthesis of 4-aryl-4,5-dihydro-1H-indeno[1,2-b]pyridine derivatives has been achieved via a four-component cyclocondensation of 1,3-indanedione, aromatic aldehydes, β-ketoesters and ammonium acetate in one-pot in the absence of catalyst and solvent at room temperature on grinding. The present approach offers several advantages such as shorter reaction times, higher yields, low

  通过1,3-茚满二酮，芳族醛，β-的四组分环缩合反应，可以实现4-芳基-4,5-二氢-1 H-茚并[1,2- b ]吡啶衍生物的简单有效合成在室温下，在不存在催化剂和溶剂的情况下，一锅法制得酮酯和乙酸铵。本方法具有几个优点，例如较短的反应时间，较高的产率，低成本，简单的后处理和容易的纯化。
• One‐pot synthesis of dihydro-1H-indeno[1,2-b] pyridines and tetrahydrobenzo[b] pyran derivatives using a new and efficient nanocomposite catalyst based on N‐butylsulfonate‐functionalized MMWCNTs-D-NH2
  作者：Fatemeh Adibian、Ali Reza Pourali、Behrooz Maleki、Mehdi Baghayeri、Amirhassan Amiri

  DOI：10.1016/j.poly.2019.114179

  日期：2020.1

  In this study, magnetic multi-walled carbon nanotubes were functionalized with polyamidoamine (PAMAM) dendrimers and modified with butylsulfonate to afford MMWCNTs-D-(CH2)(4)-So(3)H. The synthesized nanocomposite (MMWCNTs-D-(CH2)(4)-SO3H) was characterized by various techniques such as Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD) and thermo-gravimetric analysis (TGA). This nanocomposite catalyst effectively catalyzed four and three component reactions for the synthesis of dihydro-1H-Indeno[1,2-b] pyridines and tetrahydrobenzo[b] pyrans (85-98% yield in 15-20 min and 80-98% yield in 12-30 min, respectively). In addition, the magnetically recoverable catalyst could be easily recycled at least five times without significant loss of catalytic activity. In the first step of synthesis of nanocomposite the Fe3O4 nanoparticles were deposited on oxidized MWCNTs, then a modified PAMAM dendrimer was used to bond to the carbonyl groups. Finally MMWCNTs-D-NH2 functionalized with 1,4-butanesultone. (C) 2019 Elsevier Ltd. All rights reserved.
• C- and N-alkylation of 4,5-dihydro-1H-indeno[1, 2-b]pyridine derivatives
  作者：V. K. Lusis、D. Kh. Mutsenietse、A. Z. Zandersons、I. B. Mazheika、G. Ya. Dubur

  DOI：10.1007/bf00515648

  日期：1984.3
• An eco-benign and highly efficient access to dihydro-1H-indeno[1,2-b]pyridines in 2,2,2-trifluoroethanol
  作者：Samad Khaksar、Milad Gholami

  DOI：10.1016/j.molliq.2014.03.030

  日期：2014.8

  4-Aryl-4,5-dihydro-1H-indeno[1,2-b]pyridine derivatives are synthesized from both electron-deficient and electron-rich substrates in a fast, high yielding, and operationally simple protocol in 2,2,2-trifluoroethanol (TFE). The solvent (TFE) can be readily separated from reaction products and recovered in excellent purity for direct reuse. (C) 2014 Elsevier B.V. All rights reserved.
• Turhan, Kadir; Ozturkcan, S. Arda; Turgut, Zuhal, Journal of the Chemical Society of Pakistan, 2012, vol. 34, # 1, p. 94 - 101
  作者：Turhan, Kadir、Ozturkcan, S. Arda、Turgut, Zuhal

  DOI：——

  日期：——