4-(3-hydroxy-phenylsulfanyl)-butyric acid

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4-(3-hydroxy-phenylsulfanyl)-butyric acid
• 英文别名: 4-[(3-Hydroxyphenyl)thio]butanoic acid；4-(3-hydroxyphenyl)sulfanylbutanoic acid
• 化学式: C₁₀H₁₂O₃S
• 分子量: 212.269
• InChiKey: XCXPPNUEGDJRHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  82.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(3-hydroxy-phenylsulfanyl)-butyric acid 、 2-甲氧基-N-甲基苄胺 生成 4-[(3-hydroxyphenyl)thio]-N-(2-methoxybenzyl)-N-methylbutanamide
  参考文献：
  名称：

  NOVEL SUBSTITUTED ARYL DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS ANTI-HIV AGENTS

  摘要：

  本发明涉及新型取代芳基衍生物、其制备过程及其用于抑制病毒复制和治疗病毒性疾病或障碍，如HIV和/或HCV感染的用途。

  公开号：

  US20120022054A1
• 作为产物：
  描述：

  4-溴丁酸乙酯 、 3-羟基苯硫酚 在 potassium carbonate 、 sodium hydroxide 、 乙醇 、 水 、 盐酸 作用下， 以 乙醇 为溶剂， 反应 70.33h， 以72%的产率得到4-(3-hydroxy-phenylsulfanyl)-butyric acid
  参考文献：
  名称：

  WO2008/14430

  摘要：

  公开号：

文献信息

• [EN] NOVEL SUBSTITUTED ARYL DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS ANTI-HIV AGENTS<br/>[FR] NOUVEAUX DÉRIVÉS ARYLES SUBSTITUÉS, LEUR PROCÉDÉ DE PRÉPARATION ET LEURS UTILISATIONS THÉRAPEUTIQUES EN TANT QU'AGENTS ANTI-VIH
  申请人：CELLVIR

  公开号：WO2010066847A1

  公开（公告）日：2010-06-17

  The present invention concerns novel substituted aryl derivatives, their process of preparation and their use for inhibiting virus replication and for treating viral diseases or disorders such as HIV and/or HCV infection.

  本发明涉及新型取代芳基衍生物，其制备方法以及用于抑制病毒复制和治疗病毒性疾病或障碍，如HIV和/或HCV感染的用途。
• ARYLSULFANYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS
  申请人：Pusztay Stephen

  公开号：US20090258817A1

  公开（公告）日：2009-10-15

  Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are also provided.

  提供用于传递活性剂的化合物和组合物。还提供了给药和制备方法。
• Novel polyhydroxyalkanoate containing unit phenylsulfanyl structure in the side cahin, process for its production, charge control agent, toner binder and toner which contain novel polyhydroxyalkanoate, and imageforming apparatus which make use of the toner
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP1236755A2

  公开（公告）日：2002-09-04

  A polyhydroxyalkanoate is disclosed which has in the molecule a unit represented by Chemical Formula (1). wherein R is arbitrarily selected from a hydrogen atom, a halogen atom, CN, NO2, COOR', SO2R", CH3, C2H5, C3H7, C(CH3)2H and C(CH3)3; where R' is H, Na, K, CH3 or C2H5, and R" is OH, ONa, OK, a halogen atom, OCH3 or OC2H5; and x is an integer arbitrarily selected from 1 to 8; with the proviso that a polyhydroxyalkanoate is excluded which has a hydrogen atom as R and x in all the units is 2 or 4. Also disclosed is a process for producing the polyhydroxyalkanoate by the use of a microorganism having the ability to produce the polyhydroxyalkanoate and accumulate it in the bacterial body.

  本发明公开了一种聚羟基烷酸酯，其分子中具有化学式（1）所代表的单元。 其中 R 可任意选自氢原子、卤素原子、CN、NO2、COOR'、SO2R"、CH3、C2H5、C3H7、C( )2H 和 C( )3；其中 R'是 H、Na、K、 或 ，R "是 OH、ONa、OK、卤素原子、O 或 O ；x 是任意选自 1 至 8 的整数；但不包括以氢原子作为 R 且所有单元中 x 为 2 或 4 的聚羟基烷酸酯。本发明还公开了一种生产聚羟基烷酸的工艺，使用的微生物具有生产聚羟基烷酸并在细菌体内积累的能力。
• Novel substituted aryl derivatives, their process of preparation and their therapeutical uses as anti-HIV agents
  申请人：Cellvir

  公开号：EP2196453A1

  公开（公告）日：2010-06-16

  The present invention concerns novel substituted aryl derivatives, their process of preparation and their use for inhibiting integration and for treating viral diseases or disorders such as HIV.

  本发明涉及新型取代芳基衍生物、其制备过程及其用于抑制整合和治疗病毒性疾病或紊乱（如艾滋病毒）的用途。
• Novel polyhydroxyalkanoate containing unit with phenylsulfanyl structure in the side chain, process for its production, charge control agent, toner binder and toner which contain novel polyhydroxyalkanoate, and image-forming method and image-forming apparatus which make use of the toner
  申请人：——

  公开号：US20030013841A1

  公开（公告）日：2003-01-16

  A polyhydroxyalkanoate is disclosed which has in the molecule a unit represented by Chemical Formula (1). 1 wherein R is arbitrarily selected from a hydrogen atom, a halogen atom, CN, NO 2 , COOR′, SO 2 R″, CH 3 , C 2 H 5 , C 3 H 7 , C(CH 3 ) 2 H and C(CH 3 ) 3 ; where R′ is H, Na, K, CH 3 or C 2 H 5 , and R″ is OH, ONa, OK, a halogen atom, OCH 3 or OC 2 H 5 ; and x is an integer arbitrarily selected from 1 to 8; with the proviso that a polyhydroxyalkanoate is excluded which has a hydrogen atom as R and x in all the units is 2 or 4. Also disclosed is a process for producing the polyhydroxyalkanoate by the use of a microorganism having the ability to produce the polyhydroxyalkanoate and accumulate it in the bacterial body.

  本发明公开了一种聚羟基烷酸酯，其分子中含有化学式 (1) 所代表的单元。 1 其中 R 可任意选自氢原子、卤素原子、CN、NO 2 、COOR′、SO 2 R″、CH 3 , C 2 H 5 , C 3 H 7 C(CH 3 ) 2 H 和 C(CH 3 ) 3 其中 R′为 H、Na、K、CH 3 或 C 2 H 5 而 R″ 是 OH、ONa、OK、卤素原子、OCH 3 或 OC 2 H 5 和 x 是任意选自 1 至 8 的整数；但不包括以氢原子作为 R 且所有单元中 x 为 2 或 4 的聚羟基烷酸酯。本发明还公开了一种生产聚羟基烷酸的工艺，使用的微生物具有生产聚羟基烷酸并在细菌体内积累的能力。