[4-(dimethylamino)phenyl]diazene

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: [4-(dimethylamino)phenyl]diazene
• 英文别名: 4-diazenyl-N,N-dimethylaniline
• 化学式: C₈H₁₁N₃
• 分子量: 149.195
• InChiKey: WZTHXQRKSAOHGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  39.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N,N-二甲基-对苯二胺 在 盐酸 、 sodium nitrite 作用下， 以 甲醇 、 二氯甲烷 、 水 为溶剂， 生成 (4-dimethylamino-phenyl)-acetonitrile 、 [4-(dimethylamino)phenyl]diazene
  参考文献：
  名称：

  [对-（二甲基氨基）苯基]戊唑（DMAPP）在193和300 nm处的溶液光化学

  摘要：

  据报道[ p-（二甲基氨基）苯基]戊唑（DMAPP）在193 nm和近紫外光下的光化学，着重于最终稳定产物的性质。在MeCN中发现了（二甲基氨基）苯基叠氮化物（DMAPA）是主要产物，但在二氯甲烷（DCM）中却没有发现。（本文首字母缩写词DMAPP和DMAPA指对位异构体。）还探索了DMAPA的光化学性质以进行比较。在MeCN溶液中获得的数据与相应的腈的初始形成相一致，但在DCM中，根据NMR数据发现了不同的产物。如果DCM中的反应物浓度很高（10 –2M），观察到DMAPP和DMAPA的定量转化，表明高量子产率。相反，MeCN解决方案的反应要慢得多。提出了自由基型链反应机理来解释该观察。在高稀释度下，DMAPP可以在两种溶剂中完全转化为产物。讨论了解释这些结果的可能机制。

  DOI：

  10.1021/jp509815y

文献信息

• Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists
  申请人：3-Dimensional Pharmaceuticals, Inc.

  公开号：US20020037897A1

  公开（公告）日：2002-03-28

  The present invention relates to novel tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidine compounds that are antagonists of alpha V (&agr;v) integrins, for example &agr; v &bgr; 3 and &agr; v &bgr; 5 integrins, their pharmaceutically acceptable salts, and pharmaceutical compositions thereof. The compounds may be used in the treatment of pathological conditions mediated by &agr; v &bgr; 3 and &agr; v &bgr; 5 integrins, including conditions such as tumor growth, metastasis, restenosis, osteoporosis, inflammation, macular degeneration, diabetic retinopathy, and rheumatoid arthritis. The compounds have the general formula: 1 where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 R 8 , R 9 , R 10 , m and n are defined herein.

  本发明涉及一种新型的四氢异喹啉-3-羧酸烷氧基胍化合物，它们是αV（αv）整合素的拮抗剂，例如αvβ3和αvβ5整合素，其药学上可接受的盐和制药组合物。这些化合物可用于治疗由αvβ3和αvβ5整合素介导的病理性状况，包括肿瘤生长、转移、再狭窄、骨质疏松、炎症、黄斑变性、糖尿病视网膜病变和类风湿性关节炎等病症。这些化合物具有下列通式：其中，R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、m和n在本文中有定义。
• Cyanoborate, Fluoroalkylphosphate, Fluoroalkylborate or Imide Dyes
  申请人：Ignatyev Nikolai (Mykola)

  公开号：US20080275224A1

  公开（公告）日：2008-11-06

  The present invention relates to dyes of the general formula CAT + Y − (I), where Y − is an anion selected from the group of the cyanoborates, fluoroalkylphosphates, fluoroalkylborates or imidates and CAT + is a cation selected from the group of the azine, xanthene, polymethine, styryl, azo, tetrazolium, pyrylium, benzopyrylium, thiopyrylium, benzothiopyrylium, thiazine, oxazine, triarylmethane, diarylmethane, methine, acridine, quinoline, isoquinoline or quaternary azafluorenone dyes, for colouring plastics and plastic fibres, for the preparation of flexographic printing inks, as ball-point pen pastes, as stamp ink, for colouring leather and paper, for use in data acquisition systems, reprography, in ink microfilters, in photogalvanics, laser technology and the photo industry.

  本发明涉及一般公式CAT+Y-（I）的染料，其中Y-是从氰硼酸盐、氟烷基磷酸盐、氟烷基硼酸盐或咪唑盐组中选择的阴离子，CAT+是从吖嗪、黄色素、聚甲烯、苯乙烯、偶氮、四唑、吡啶杂环、苯并吡喃杂环、硫吡喃杂环、苯并硫吡喃杂环、噻吩、噁吩、三芳基甲烷、二芳基甲烷、甲烯、花菁、喹啉、异喹啉或季铵氮杂花菁染料组中选择的阳离子，用于染色塑料和塑料纤维，用于制备凹版印刷油墨，作为圆珠笔浆料、邮票墨水，用于染色皮革和纸张，用于数据采集系统、复印、油墨微滤器、光电镀、激光技术和照相产业。
• CYANOBORATE, FLUOROALKYLPHOSPHATE, FLUOROALKYLBORATE OR IMIDE DYES
  申请人：IGNATYEV Nikolai (Mykola)

  公开号：US20110190480A1

  公开（公告）日：2011-08-04

  The present invention relates to dyes of the general formula CAT + Y − (I), where Y − is an anion selected from the group of the cyanoborates, fluoroalkylphosphates, fluoroalkylborates or imidates and CAT + is a cation selected from the group of the azine, xanthene, polymethine, styryl, azo, tetrazolium, pyrylium, benzopyrylium, thiopyrylium, benzothiopyrylium, thiazine, oxazine, triarylmethane, diarylmethane, methine, acridine, quinoline, isoquinoline or quaternary azafluorenone dyes, for colouring plastics and plastic fibres, for the preparation of flexographic printing inks, as ball-point pen pastes, as stamp ink, for colouring leather and paper, for use in data acquisition systems, reprography, in ink microfilters, in photogalvanics, laser technology and the photo industry.

  本发明涉及一般式CAT+Y−（I）的染料，其中Y−是从氰硼酸盐、氟烷基磷酸盐、氟烷基硼酸盐或咪唑盐群中选择的阴离子，CAT+是从偶氮、黄色素、聚甲烯、苯乙烯、偶氮、四唑、吡啶、苯并吡喃、硫吡喃、苯并硫吡喃、噻吩、噁唑、三芳基甲烷、二芳基甲烷、甲烷、吖啶、喹啉、异喹啉或季铵氮芴酮染料群中选择的阳离子，用于着色塑料和塑料纤维，制备柔性版印刷油墨，作为圆珠笔膏、邮票墨水，用于着色皮革和纸张，用于数据采集系统，复印术，墨水微滤器，光电镀技术，激光技术和光学工业。
• Dental composition for detection of carious tissue, detection method
  申请人：3M ESPE AG

  公开号：EP1733762A1

  公开（公告）日：2006-12-20

  The present invention relates to a composition comprising an aqueous solution of 1) at least one acidic compound, 2) at least one salt of said acidic compound. 3) at least one indicator that generates a detectable signal when said solution reaches a particular pH value that is less than 5.5 wherein 1) and 2) are selected such that the aqueous solution has a pH of less than that particular pH value where the indicator generates the signal. It further relates to a method for detection of carious tissue on the surface of a tooth, comprising the steps of 1) providing the above mentioned composition, 2) applying said composition to the surface of said tooth, and 3) measuring the amount of time required for the composition to change color. It further relates to the use of said composition to manufacture a remedy for detection of carious tissue.

  本发明涉及一种组合物，该组合物由以下物质的水溶液组成 1) 至少一种酸性化合物、 2) 至少一种所述酸性化合物的盐。 3) 至少一种指示剂，当所述溶液达到小于 5.5 的特定 pH 值时，该指示剂会产生可检测的信号。 其中 1) 和 2) 的选择应使水溶液的 pH 值小于指示剂产生信号的特定 pH 值。 本发明还涉及一种检测牙齿表面龋坏组织的方法，包括以下步骤：1）提供上述组合物；2）将所述组合物涂在所述牙齿表面；3）测量组合物变色所需的时间。 它还涉及使用上述组合物制造检测龋齿组织的补救剂。
• RNA ACTION INHIBITOR AND USE THEREOF
  申请人：National University Corporation Tokai National Higher Education and Research System

  公开号：EP4019088A1

  公开（公告）日：2022-06-29

  Provided is an agent for inhibiting the action of a target RNA based on RNA interference and ASO. The RNA interference agent is provided with a passenger strand and a guide strand for a target RNA, wherein both ends of double-stranded RNA formed pairing of the passenger strand and the guide strand are blunt ends, and one or two or more selected from the group consisting of the units represented by formula (1) and formula (2) below are provided at the following positions (a) and (b): (a) 5' end side and 3' end side of the passenger strand, (b) 3' end side of the guide strand (in which X represents an oxygen atom or sulfur atom), (in which X represents an oxygen atom or sulfur atom).

  本发明提供了一种基于 RNA 干扰和 ASO 的抑制靶 RNA 作用的制剂。该 RNA 干扰剂具有一条客链和一条目标 RNA 的引导链，其中客链和引导链配对形成的双链 RNA 的两端均为钝端，并在以下位置（a）和（b）提供一个或两个或两个以上选自由式（1）和式（2）代表的单元组成的组： (a) 客链的 5'端侧和 3'端侧、 (b) 导向链的 3'端侧 (其中 X 代表氧原子或硫原子）、 (其中 X 代表氧原子或硫原子）。