N-methyl-N-(4-chlorophenyl)sulfamoyl chloride | 868622-96-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-methyl-N-(4-chlorophenyl)sulfamoyl chloride
• 英文别名: [[N-methyl-N-(4-chlorophenyl)]amino]sulfamoylchloride；(4-Chlorophenyl)methylsulfamyl chloride；N-(4-chlorophenyl)-N-methylsulfamoyl chloride
• CAS: 868622-96-2
• 化学式: C₇H₇Cl₂NO₂S
• mdl: MFCD19200493
• 分子量: 240.11
• InChiKey: QWJYHEJXSQDOEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-methyl-N-(4-chlorophenyl)sulfamoyl chloride 以 二氯甲烷 、 乙腈 为溶剂， 反应 2.0h， 生成 N-methyl-N-(4-chlorophenyl)sulfamoyl-2-methylimidazolium triflate
  参考文献：
  名称：

  Efficient synthesis of arylsulfamides by reaction of amines with arylsulfamoyl imidazolium triflate

  摘要：

  Aryisulfamoyl imidazolium triflates, readily prepared from the corresponding chlorides, react with amines under neutral conditions to form arylsulfamides in high yields. This methodology, which contrasts with the slow and inefficient reactions of amines with arylsulfamoyl chlorides, is applied to the synthesis of arylsulfamide 3a, a bioisotere of muraglitazar. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.08.092

文献信息

• [EN] SULFAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR UPREGULATION OF LIPID METABOLISM COMPRISING SAME<br/>[FR] DERIVES DE SULFAMIDE ET COMPOSITION PHARMACEUTIQUE SERVANT A REGULER POSITIVEMENT LE METABOLISME DES LIPIDES ET CONTENANT CES DERIVES
  申请人：CRYSTALGENOMICS INC

  公开号：WO2006006832A1

  公开（公告）日：2006-01-19

  The present invention relates to a novel sulfamide derivative, a pharmaceutically acceptable salt thereof and a pharmaceutical composition for upregulation of lipid metabolism comprising same as an active ingredient.

  本发明涉及一种新型磺胺酰胺衍生物，其药用可接受的盐以及一种含有其作为活性成分的用于上调脂质代谢的制药组合物。
• Sulfamide Derivatives and Pharmaceutical Composition for Upregulation of Lipid Metabolism Comprising Same
  申请人：Cho Myung Joong

  公开号：US20070254882A1

  公开（公告）日：2007-11-01

  The present invention relates to a novel sulfamide derivative, a pharmaceutically acceptable salt thereof and a pharmaceutical composition for upregulation of lipid metabolism comprising same as an active ingredient.

  本发明涉及一种新型磺酰胺衍生物、其药学上可接受的盐以及包含其作为活性成分的上调脂质代谢的药物组合物。
• SULFAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR UPREGULATION OF LIPID METABOLISM COMPRISING SAME
  申请人：Crystalgenomics, Inc.

  公开号：EP1778654A1

  公开（公告）日：2007-05-02
• Efficient synthesis of arylsulfamides by reaction of amines with arylsulfamoyl imidazolium triflate
  作者：Hyeon Kyu Lee、Miyeon Bang、Chwang Siek Pak

  DOI：10.1016/j.tetlet.2005.08.092

  日期：2005.10

  Aryisulfamoyl imidazolium triflates, readily prepared from the corresponding chlorides, react with amines under neutral conditions to form arylsulfamides in high yields. This methodology, which contrasts with the slow and inefficient reactions of amines with arylsulfamoyl chlorides, is applied to the synthesis of arylsulfamide 3a, a bioisotere of muraglitazar. (c) 2005 Elsevier Ltd. All rights reserved.