(R)-5-(azidomethyl)-3-(3-fluoro-4-(piperazin-1-yl)phenyl)oxazolidin-2-one | 221201-21-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (R)-5-(azidomethyl)-3-(3-fluoro-4-(piperazin-1-yl)phenyl)oxazolidin-2-one
• 英文别名: (R)-N-5-(azidomethyl)-3-(3-fluoro-4-piperazin-1-ylphenyl)-1,3-oxazolidin-2-one；(S)-N-[3-[3-fluoro-4-[piperazin-1-yl]phenyl]-2-oxooxazolidin-5-ylmethyl]azide；(R)-5-azidomethyl-3-[3-fluoro-4-(piperazin-1-yl)phenyl]-2-oxooxazolidine；(5R)-5-(azidomethyl)-3-(3-fluoro-4-piperazin-1-ylphenyl)-1,3-oxazolidin-2-one
• CAS: 221201-21-4
• 化学式: C₁₄H₁₇FN₆O₂
• 分子量: 320.326
• InChiKey: IBRYRMDESZLQBO-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  59.2
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (R)-5-(azidomethyl)-3-(3-fluoro-4-(piperazin-1-yl)phenyl)oxazolidin-2-one 以 乙醇 为溶剂， 生成 Ethyl (R)-3-[4-[4-(5-azidomethyl-2-oxooxazolidin-3-yl)-2-fluorophenyl]-piperazin-1-yl]propionate
  参考文献：
  名称：

  EP1130016

  摘要：

  公开号：
• 作为产物：
  描述：

  (R)-4-(2-氟-4-(5-(羟基甲基)-2-氧代噁唑啉-3-基)苯基)哌嗪-1-羧酸叔丁酯 在 sodium azide 、 三乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 (R)-5-(azidomethyl)-3-(3-fluoro-4-(piperazin-1-yl)phenyl)oxazolidin-2-one
  参考文献：
  名称：

  带有N-羟基乙am取代基的新型恶唑烷酮的合成及其抗菌活性。

  摘要：

  合成了具有N-羟基乙moiety部分的新型恶唑烷酮抗菌剂，其在C-5末端具有多样性。已针对一组临床相关的革兰氏阳性和革兰氏阴性病原体对这些化合物进行了评估。该系列中的大多数类似物显示出优于利奈唑胺的活性，并且本文还公开了选定的恶唑烷酮的体内功效。

  DOI：

  10.1016/j.bmcl.2006.01.109

文献信息

• [EN] NOVEL ANTIBACTERIAL AGENTS<br/>[FR] NOUVEAUX AGENTS ANTIBACTERIENS
  申请人：ORCHID CHEMICALS & PHARM LTD

  公开号：WO2004018439A1

  公开（公告）日：2004-03-04

  The present invention provides novel compounds of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present invention more particularly provides novel oxazolidinone derivatives of the general formula (I).

  本发明提供了一般式(I)的新化合物，它们的衍生物、类似物、互变异构体、立体异构体、多晶形态、水合物、溶剂合物、药学上可接受的盐以及含有它们的药学上可接受的组合物。本发明特别提供了一般式(I)的新噁唑啉酮衍生物。
• antibacterial agents
  申请人：Agarwal Kumar Shiv

  公开号：US20050203102A1

  公开（公告）日：2005-09-15

  The present invention provides novel compounds of the general formula (I) and their pharmaceutically acceptable salts. The present invention more particularly provides novel oxazolidinone derivatives of the general formula (I).

  本发明提供了一般式(I)的新化合物及其药学上可接受的盐。本发明更特别地提供了一般式(I)的新的噁唑烷酮衍生物。
• THIOCARBAMIC ACID DERIVATIVES
  申请人：HOKURIKU SEIYAKU CO., LTD.

  公开号：EP1130016A1

  公开（公告）日：2001-09-05

  Thiocarbamic acid derivatives represented by the following general formula or salts thereof which are useful as antibacterial agents: wherein R1 represents an alkyl group which may be substituted, or a cycloalkyl group which may be substituted; and R2, R3, and R4 independently represent hydrogen atom, a halogen atom, an alkyl group which may be substituted, an alkogyl group which may be substituted, an amino group which may be substituted, an alkanoyl group which may be substituted, a cycloalkyloxy group which has a heteroatom as a ring constituting atom and which may be substituted, or a saturated heterocyclic group which may be substituted; or any two of R2, R3, and R4 may bind to each other to form, together with the benzene ring, a condensed hydrocarbon ring which may be substituted.

  由以下通式代表的可用作抗菌剂的硫代氨基甲酸衍生物或其盐： 其中 R1 代表可被取代的烷基，或可被取代的环烷基；R2、R3 和 R4 独立地代表氢原子、卤素原子、可被取代的烷基、可被取代的烷酰基、可被取代的氨基、可被取代的烷酰基、具有杂原子作为成环原子且可被取代的环烷氧基，或可被取代的饱和杂环基；或 R2、R3 和 R4 中的任意两个可相互结合，与苯环一起形成一个可被取代的缩合烃环。
• Derivatives of oxazolidinones as antibacterial agents
  申请人：——

  公开号：US20040147545A1

  公开（公告）日：2004-07-29

  This invention discloses new fluorquinolonic derivatives of oxazolidinones of general formula (I) and processes for obtaining them, the corresponding pharmaceutical compositions and use thereof for manufacturing a medicament for the treatment of microbial infections. These new compounds are useful as antibacterial agents. Formula (I). Furthermore phenalen-type compounds according to general formula (II) are disclosed. Formula (II).

  本发明公开了通式(I)的噁唑烷酮的新氟喹诺酮衍生物、获得它们的工艺、相应的药物组合物及其用于制造治疗微生物感染的药物。这些新化合物可用作抗菌剂。式 (I)。此外，还公开了通式（II）的苯茚类化合物。式 (II).
• Anti-tubercular agents. Part 7: A new class of diarylpyrrole–oxazolidinone conjugates as antimycobacterial agents
  作者：Ahmed Kamal、P. Swapna、Rajesh V.C.R.N.C. Shetti、Anver Basha Shaik、M.P. Narasimha Rao、Farheen Sultana、Inshad Ali Khan、Sandeep Sharma、Nitin Pal Kalia、Sunil Kumar、Bagul Chandrakant

  DOI：10.1016/j.ejmech.2013.03.027

  日期：2013.6

  In an effort to discover new anti-tubercular agents, a series of new diarylpyrrole oxazolidinone conjugates have been designed and synthesized. The anti-tubercular activity of these new conjugates (4a-n and 5a-d) against Mycobacterium tuberculosis H(37)Rv and drug resistance strains such as M. tuberculosis Rif(R) and M. tuberculosis XDR are discussed, wherein compound 4i has been found to be the most potent amongst the series. MTT assay was performed on the active conjugates of the series (4b-f, 4i and 5c) against mouse macrophage (J-774) cells to evaluate cytotoxic effects and selective index values. In addition, these conjugates (4a-n and 5a-d) are also tested against a panel of Gram-positive and Gram-negative bacterial strains. The docking studies have been carried out to provide some insight into the mechanism of action for this class of compounds. (C) 2013 Published by Elsevier Masson SAS.