1,3-dimethoxy-4-(4-methoxybenzyl)benzene | 53039-53-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,3-dimethoxy-4-(4-methoxybenzyl)benzene
• 英文别名: Benzene, 2,4-dimethoxy-1-[(4-methoxyphenyl)methyl]-；2,4-dimethoxy-1-[(4-methoxyphenyl)methyl]benzene
• CAS: 53039-53-5
• 化学式: C₁₆H₁₈O₃
• 分子量: 258.317
• InChiKey: JGSPILACYXJHEA-UHFFFAOYSA-N

物化性质

• 沸点：
  120-130 °C(Press: 0.02 Torr)
• 密度：
  1.072±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,4,4’-三甲氧基苯甲酮 在 lithium aluminium tetrahydride 、 三氯化铝 、 乙醚 作用下， 生成 1,3-dimethoxy-4-(4-methoxybenzyl)benzene
  参考文献：
  名称：

  739.用氯化铝和氢化铝锂对芳族羰基化合物和醇进行氢解

  摘要：

  DOI：

  10.1039/jr9570003755

文献信息

• Iron-Catalyzed Friedel-Crafts Benzylation with Benzyl TMS Ethers at Room Temperature
  作者：Yoshinari Sawama、Yuko Shishido、Takahiro Kawajiri、Ryota Goto、Yasunari Monguchi、Hironao Sajiki

  DOI：10.1002/chem.201302862

  日期：2014.1.7

  conditions. The reaction seems to progress through iron‐catalyzed self‐condensation of the benzyl TMS ether to the corresponding dibenzylic ether. The use of excess arene relative to benzyl TMS ether produced mono‐benzylated arene (di‐ and tri‐arylmethane products), whereas the use of excess benzyl TMS ether versus arene provided bis‐benzylated arene (polyarylated products) in high yields and regioselectivities

  未活化的芳烃和苯甲醇衍生物之间的Friedel-Crafts苄基化反应是清洁且直接的方法，可用于构建对生物有用的二芳基和三芳基甲烷。我们建立了一种在室温下有效的铁催化的Friedel-Crafts苄基化方法，该方法使用苄基TMS醚作为底物，在常见的亲核取代条件下反应性较差。该反应似乎是通过铁催化的苄基TMS醚自缩合为相应的二苄基醚而进行的。相对于苄基TMS醚生产的单苄基化芳烃（二芳基和三芳基甲烷产物）使用过量的芳烃，而相对于芳烃使用过量的苄基TMS醚则可提供高收率和区域选择性的双苄基化芳烃（多芳基化产物）。在以前的方法中，
• Cerium(III) Triflate versus Cerium(III) Chloride: Anion Dependence of Lewis Acid Behavior in the Deprotection of PMB Ethers
  作者：Giuseppe Bartoli、Renato Dalpozzo、Antonio De Nino、Loredana Maiuolo、Monica Nardi、Antonio Procopio、Antonio Tagarelli

  DOI：10.1002/ejoc.200400039

  日期：2004.5

  Cerium(III) triflate deprotects p-methoxybenzyl ethers of simple alcohols better than the cerium(III) chloride/sodium iodide system. It can be used in 1% M instead of equimolecular amounts, giving better yields. Aromatic alcohols rearrange, but the addition of a scavenger overcomes this drawback. Unfortunately, unsaturated alcohols are deprotected with decomposition, probably due to side electrophilic

  三氟甲磺酸铈 (III) 比氯化铈 (III)/碘化钠体系更好地对简单醇的对甲氧基苄基醚进行脱保护。它可以以 1% M 代替等分子量使用，从而获得更好的产率。芳香醇重排，但添加清除剂克服了这个缺点。不幸的是，不饱和醇会因分解而脱保护，这可能是由于双键的侧亲电加成。报道了三氟甲磺酸铈和氯化铈机制之间的比较。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
• Drugs containing triazaspiro[5.5]undecane derivatives as the active ingredient
  申请人：——

  公开号：US20040106619A1

  公开（公告）日：2004-06-03

  A pharmaceutical composition for prevention and/or treatment for HIV infection or AIDS induced by the infection which comprises, as an active ingredient, a triazaspiro[5.5]undecane derivative, a quaternary ammonium salt thereof, an N-oxide thereof, or a non-toxic salt thereof, and if necessary, it may be combined with at least one member of other agents for prevention and/or treatment for HIV infection (wherein all symbols are as defined in the specification.). 1 The triazaspiro[5.5]undecane derivatives, the quaternary ammonium salts thereof or the N-oxides thereof, or the non-toxic salts thereof are useful in preventing and/or treating HIV infection and AIDS induced by the infection.

  一种用于预防和/或治疗由HIV感染引起的艾滋病的药物组合物，其作为活性成分包括三氮杂螺[5.5]十一烷衍生物、其季铵盐、其N-氧化物或其非毒性盐，如有必要，还可以与其他预防和/或治疗HIV感染的药物组合使用（其中所有符号均如规范中定义） 。1三氮杂螺[5.5]十一烷衍生物、其季铵盐或其N-氧化物，或其非毒性盐在预防和/或治疗HIV感染和由该感染引起的艾滋病中有用。
• Palladium-catalyzed cross-coupling of benzene sulfonhydrazides and benzyltrimethylammonium salts: Synthesis of diarylmethanes
  作者：Weijie Yu、Juelin Wan、Puqing Chen、Kuang Zhao、Haijin Huang、Tao Wang、Jin Luo

  DOI：10.1080/00397911.2023.2172347

  日期：2023.3.19

  Abstract A palladium-catalyzed cross-coupling of benzene sulfonyl hydrazides with benzyltrimethylammonium salts via C–S bond and C–N bond cleavage is reported. This reaction proceeds under mild reaction conditions and provides a new strategy for the synthesis of various diarylmethanes with broad functional group tolerance in moderate to good yields.

  摘要 报道了钯催化的苯磺酰肼与苄基三甲基铵盐通过 C-S 键和 C-N 键断裂的交叉偶联。该反应在温和的反应条件下进行，为以中等至良好的收率合成具有广泛官能团耐受性的各种二芳基甲烷提供了一种新策略。
• DRUGS CONTAINING TRIAZASPIRO 5.5]UNDECANE DERIVATIVES AS THE ACTIVE INGREDIENT
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1378509A1

  公开（公告）日：2004-01-07

  A pharmaceutical composition for prevention and/or treatment for HIV infection or AIDS induced by the infection which comprises, as an active ingredient, a triazaspiro[5.5]undecane derivative, a quaternary ammonium salt thereof, an N-oxide thereof, or a non-toxic salt thereof, and if necessary, it may be combined with at least one member of other agents for prevention and/or treatment for HIV infection (wherein all symbols are as defined in the specification.). The triazaspiro[5.5]undecane derivatives, the quatemary ammonium salts thereof or the N-oxides thereof, or the non-toxic salts thereof are useful in preventing and/or treating HIV infection and AIDS induced by the infection.

  一种用于预防和/或治疗HIV感染或由该感染诱发的艾滋病的药物组合物，作为活性成分，它包括一种三氮杂螺[5.5]十一烷衍生物、其季铵盐、其N-氧化物或其无毒盐，必要时，它可与至少一种用于预防和/或治疗HIV感染的其他制剂成员结合使用（其中所有符号如说明书中所定义。） 三氮杂螺[5.5]十一烷衍生物、其藜芦铵盐或其N-氧化物或其无毒盐可用于预防和/或治疗HIV感染和由感染诱发的艾滋病。