2-[4-(2,3-Dioxoindol-1-yl)butyl]isoindole-1,3-dione | 1309650-42-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-[4-(2,3-Dioxoindol-1-yl)butyl]isoindole-1,3-dione
• CAS: 1309650-42-7
• 化学式: C₂₀H₁₆N₂O₄
• 分子量: 348.358
• InChiKey: QXUZCLKZIQDJSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  74.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  靛红 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.33h， 生成 2-[4-(2,3-Dioxoindol-1-yl)butyl]isoindole-1,3-dione
  参考文献：
  名称：

  Synthesis and in vitro cytotoxic evaluation of N-alkylbromo and N-alkylphthalimido-isatins

  摘要：

  The manuscript pertains to the synthesis and in vitro cytotoxic evaluation of a series of N-alkylbromo and N-alkylphthalimido-isatins against four different human cancer cell lines namely Colon: HCT-15; Liver: Hep-2; Lung: A-549 and Leukemia: THP-1 at 10 and 100 mu M concentrations. The active compounds based on preliminary studies were evaluated for their IC(50) value against six cell lines viz. Colo-205, HCT-15 (Colon), THP-1 (Leukemia), A-549 (Lung), PC-3 (Prostate) and HeLa (Cervix). The active analogue IS-4 exhibited IC(50) values of 4.57, 10.90, 11.75, 12.40 and 54.20 mu M against HeLa, PC-3, HCT-15, THP-1 and Colo-205, respectively. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.03.043

文献信息

• Synthesis and in vitro cytotoxic evaluation of N-alkylbromo and N-alkylphthalimido-isatins
  作者：Pardeep Singh、Sharanjeet Kaur、Vipan Kumar、P.M.S. Bedi、M.P. Mahajan、Irum Sehar、Harish Chandra Pal、Ajit Kumar Saxena

  DOI：10.1016/j.bmcl.2011.03.043

  日期：2011.5

  The manuscript pertains to the synthesis and in vitro cytotoxic evaluation of a series of N-alkylbromo and N-alkylphthalimido-isatins against four different human cancer cell lines namely Colon: HCT-15; Liver: Hep-2; Lung: A-549 and Leukemia: THP-1 at 10 and 100 mu M concentrations. The active compounds based on preliminary studies were evaluated for their IC(50) value against six cell lines viz. Colo-205, HCT-15 (Colon), THP-1 (Leukemia), A-549 (Lung), PC-3 (Prostate) and HeLa (Cervix). The active analogue IS-4 exhibited IC(50) values of 4.57, 10.90, 11.75, 12.40 and 54.20 mu M against HeLa, PC-3, HCT-15, THP-1 and Colo-205, respectively. (C) 2011 Elsevier Ltd. All rights reserved.