2,7-diiodo-9,9-bis[2-[2-(2-methoxyethoxy)ethoxy]ethyl]-9H-fluorene | 1312471-97-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 2,7-diiodo-9,9-bis[2-[2-(2-methoxyethoxy)ethoxy]ethyl]-9H-fluorene
• 英文别名: 2,7-diiodo-9,9-bis[2-[2-(2-methoxyethoxy)ethoxy]ethyl]fluorene
• CAS: 1312471-97-8
• 化学式: C₂₇H₃₆I₂O₆
• 分子量: 710.388
• InChiKey: IGYAOQSIVUWFNZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  35
• 可旋转键数：
  18
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  55.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,7-diiodo-9,9-bis[2-[2-(2-methoxyethoxy)ethoxy]ethyl]-9H-fluorene 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 三乙胺 、 sodium hydroxide 作用下， 以 异丙醇 、 甲苯 为溶剂， 反应 19.5h， 生成 2,7-diethynyl-9,9-bis[2-[2-(2-methoxyethoxy)ethoxy]ethyl]-9H-fluorene
  参考文献：
  名称：

  [EN] BIPHOTONIC PHOTOSENSITIZERS, NANOPARTICLES CONTAINING THE SAME AND THEIR USE AS DRUGS
  [FR] PHOTOSENSIBILISATEURS BIPHOTONIQUES, NANOPARTICULES LES CONTENANT ET LEUR UTILISATION COMME MÉDICAMENTS

  摘要：

  该发明涉及式(I)的化合物：其中基团A和基团B分别独立地表示-CH=CH-或-C≡C-，术语t、u、v、w分别独立地表示从0到9的值，基团Y1和基团Y2可以独立地表示一个烷基基团（直链、支链或取代基）带有1到9个碳原子，基团Z1、Z2、Z3和Z4可以独立地表示化学反应性基团W，例如OH、NH2、SH，基团Z5和Z6可以独立地表示氢原子，以及这些化合物功能化的二氧化硅纳米颗粒及其作为药物的用途。

  公开号：

  WO2011073054A1
• 作为产物：
  描述：

  芴 在 硫酸 、 四丁基溴化铵 、 碘 、 溶剂黄146 、 高碘酸 、 sodium hydroxide 作用下， 以 水 、 甲苯 为溶剂， 反应 9.0h， 生成 2,7-diiodo-9,9-bis[2-[2-(2-methoxyethoxy)ethoxy]ethyl]-9H-fluorene
  参考文献：
  名称：

  Strong enhancement of two-photon absorption properties in synergic ‘semi-disconnected’ multiporphyrin assemblies designed for combined imaging and photodynamic therapy

  摘要：

  The synthesis and photophysical properties of new multiporphyrin assemblies are described. Their design, based on a smooth electronic disconnection between two-photon absorbing (2PA) octupolar or quadrupolar cores and the peripheral porphyrins, leads to a major increase in (non-resonant) 2PA responses in the NIR, while fully retaining the fluorescence and photosensitization properties of isolated porphyrins. This approach, which involves electronic coupling of semi-disconnected moieties in the higher excited states of the synergic systems, is of interest to fully benefit from the advantages of selective 2PA for application in combined two-photon high resolution imaging and photodynamic therapy. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.09.076

文献信息

• Tandem triad systems based on FRET for two-photon induced release of glutamate
  作者：Sébastien Picard、Eduardo Jose Cueto-Diaz、Emilie Genin、Guillaume Clermont、Francine Acher、David Ogden、Mireille Blanchard-Desce

  DOI：10.1039/c3cc45812a

  日期：——

  Tandem systems allowing enhanced two-photon (2P) absorption in a wavelength range permitting coupling of the primary excitation by energy transfer to an intramolecular cage known to have fragmentation properties suited to photolysis in neuroscience is demonstrated to lead to a 10-fold improvement in the 2P photolysis cross-section at experimentally compatible wavelengths.

  显示出允许增强双光子（2P）吸收的串联系统，在一个允许通过能量转移耦合主激发的波长范围内，与已知具有适合神经科学光解的碎裂特性的分子内笼结合，导致在实验兼容波长下2P光解截面提高了10倍。
• Octupolar chimeric compounds built from quinoline caged acetate moieties: a novel approach for 2-photon uncaging of biomolecules
  作者：Sébastien Picard、Emilie Genin、Guillaume Clermont、Vincent Hugues、Olivier Mongin、Mireille Blanchard-Desce

  DOI：10.1039/c3nj00833a

  日期：——

  8-quinoline caging units are integrated in multipolar systems to yield “hybrid” molecular structures for two-photon uncaging. These systems were demonstrated to exhibit strikingly enhanced (up to more than 2 orders of magnitude larger for octupolar derivatives) two-photon absorption responses in the NIR region compared to common caging groups. Whereas the quadrupolar compound shows the lowest two-photon uncaging

  本研究描述了嵌合结构的合成和研究，其中将6喹啉和8喹啉笼罩单元集成在多极系统中，以产生用于双光子解笼的“杂化”分子结构。与常见的笼养组相比，这些系统被证明在NIR区域表现出惊人的增强（对于八极衍生物最大大于2个数量级）的双光子吸收响应。而四极化合物显示了最低的双光子解笼锁的横截面（δ Û），八极嵌合衍生物显示一阶大δ ü比它们的偶极类似物值。这为设计用于生物分子的双光子开封的有效八极型衍生物设计开辟了一条有希望的途径。
• BIPHOTONIC PHOTOSENSITIZERS, NANOPARTICLES CONTAINING THE SAME AND THEIR USE AS DRUGS
  申请人：Brevet David

  公开号：US20130065849A1

  公开（公告）日：2013-03-14

  The invention relates to compounds of formula (I) wherein the groups A and B represent independently from each other —CH═CH—, or —C≡C—, the terms t, u, v, w represent, independently from each other, values ranging from 0 to 9, the groups Y 1 and Y 2 can represent independently from each other an alkyl group (linear, branched or substituted) carrying from 1 to 9 carbon atoms, the groups Z 1 , Z 2 , Z 3 , and Z 4 can represent independently from each other a chemically reactive group W, such as OH, NH 2 , SH, the groups Z 5 and Z 6 represent independently from each other a hydrogen atom, silica nanoparticles functionalized by these compounds, and their use as drugs.

  本发明涉及公式(I)的化合物，其中A和B基团分别独立地表示—CH═CH—或—C≡C—，t、u、v和w术语分别独立地表示从0到9的值，Y1和Y2基团可以独立地表示带有1到9个碳原子的烷基基团（直链、支链或取代基），Z1、Z2、Z3和Z4基团可以独立地表示化学反应性基团W，例如OH、NH2、SH，Z5和Z6基团可以独立地表示氢原子，以及由这些化合物功能化的二氧化硅纳米颗粒和它们作为药物的用途。
• Biphotonic photosensitizers, nanoparticles containing the same and their use as drugs
  申请人：Brevet David

  公开号：US08709747B2

  公开（公告）日：2014-04-29

  The invention relates to compounds of formula (I) wherein the groups A and B represent independently from each other —CH═CH—, or —C≡C—, the terms t, u, v, w represent, independently from each other, values ranging from 0 to 9, the groups Y1 and Y2 can represent independently from each other an alkyl group (linear, branched or substituted) carrying from 1 to 9 carbon atoms, the groups Z1, Z2, Z3, and Z4 can represent independently from each other a chemically reactive group W, such as OH, NH2, SH, the groups Z5 and Z6 represent independently from each other a hydrogen atom, silica nanoparticles functionalized by these compounds, and their use as drugs.

  本发明涉及公式（I）的化合物，其中A和B代表独立的—CH═CH—或—C≡C—，t、u、v、w分别独立地表示从0到9的值，Y1和Y2代表独立的烷基（直链、支链或取代）并携带1至9个碳原子，Z1、Z2、Z3和Z4代表独立的化学反应基W，例如OH、NH2、SH，Z5和Z6代表独立的氢原子，以这些化合物功能化的二氧化硅纳米颗粒，以及它们作为药物的用途。
• US8709747B2
  申请人：——

  公开号：US8709747B2

  公开（公告）日：2014-04-29