2-naphthyl 2-thienyl ketone | 56662-34-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-naphthyl 2-thienyl ketone
• 英文别名: naphthalen-2-yl-thiophen-2-yl-methanone；[2]naphthyl-[2]thienyl ketone；[2]Naphthyl-[2]thienyl-keton；2-Naphthyl-2-thienylketon；Naphthalen-2-yl(thiophen-2-yl)methanone
• CAS: 56662-34-1
• 化学式: C₁₅H₁₀OS
• mdl: MFCD07775977
• 分子量: 238.31
• InChiKey: SALRAPLQXYHEAI-UHFFFAOYSA-N

物化性质

• 熔点：
  87 °C
• 沸点：
  409.6±18.0 °C(Predicted)
• 密度：
  1.246±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  45.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-naphthyl 2-thienyl ketone 在 sodium tetrahydroborate 作用下， 以 四氢呋喃 、 水 、 乙腈 为溶剂， 反应 1.0h， 生成 1-(Naphthalen-2-yl-thiophen-2-yl-methyl)-1H-imidazole
  参考文献：
  名称：

  Research on antibacterial and antifungal agents. 16. Synthesis and antifungal activities of 1-[α-(1-naphthyl)benzyl]imidazole derivatives and related 2-naphthyl isomers

  摘要：

  Some 1-arylmethylimidazoles bearing a naphthyl group at the a position of benzyl moiety have been synthesized and tested as antifungal agents against Candida albicans and Candida spp. Such derivatives resemble bifonazole and naftifine, two important antimycotic agents of clinical use. Various compounds were found highly active when tested against Candida strains in comparison with bifonazole, miconazole, clotrimazole and ketoconazole.

  DOI：

  10.1016/0223-5234(92)90089-j
• 作为产物：
  描述：

  1,2-萘二酸酐 在 copper (II) carbonate hydroxide 、 乙醚 、 苯 作用下， 生成 2-naphthyl 2-thienyl ketone
  参考文献：
  名称：

  Synthesis of 9,10-Dimethyl-1,2-benzanthracene and of a Thiophene Isolog

  摘要：

  DOI：

  10.1021/ja01868a055

文献信息

• Synthesis of11C-/13C-Ketones by Suzuki Coupling
  作者：Obaidur Rahman、Tor Kihlberg、Bengt Långström

  DOI：10.1002/ejoc.200300527

  日期：2004.2

  Aryl triflates, methyl- or arylboronic acids, and a low concentration of [11C]carbon monoxide were employed on small scale in the syntheses of fifteen 11C-labelled ketones using palladium-mediated ...

  芳基三氟甲磺酸酯、甲基或芳基硼酸和低浓度的 [11C] 一氧化碳在使用钯介导的 15 种 11C 标记的酮的合成中小规模使用...
• 2-amino-3-aroyl-4,5 alkylthiophenes: agonist allosteric enhancers at human A1 adenosine receptors
  申请人：——

  公开号：US20030078248A1

  公开（公告）日：2003-04-24

  The present invention relates to a compound of formula (I): 1 wherein: R 3 is selected from the group consisting of 1-napthyl, 2-napthyl and cycloalkylphenyl; and R 4 and R 5 taken together form a ring having from 5 to 10 carbon atoms. Additionally, the invention provides a therapeutic method for preventing or treating a pathological condition or symptom in a mammal subject, such as a human, wherein increased angiogenesis is desired, comprising administering to a mammal in need of such therapy an effective amount of the aforementioned thiophene selective adenosine A 1 allosteric enhancer.

  本发明涉及以下式（I）的化合物：其中：R3选择自1-萘基、2-萘基和环烷基苯基所组成的群；以及R4和R5一起形成含有5到10个碳原子的环。此外，本发明提供了一种治疗方法，用于预防或治疗哺乳动物主体（如人类）中的病理状况或症状，其中需要增加血管生成，包括向需要此类治疗的哺乳动物中施用上述噻吩选择性腺苷A1受体变构增强剂的有效量。
• 2-Amino-3-aroyl-4,5 alkylthiophenes: agonist allosteric enhancers at human A1 adenosine receptors
  申请人：——

  公开号：US20040180948A1

  公开（公告）日：2004-09-16

  The present invention relates to a compound of formula (I): 1 wherein: R 3 is selected from the group consisting of 1-napthyl, 2-napthyl and cycloalkylphenyl; and R 4 and R 5 taken together form a ring having from 5 to 10 carbon atoms. Additionally, the invention provides a therapeutic method for preventing or treating a pathological condition or symptom in a mammal subject, such as a human, wherein increased angiogenesis is desired, comprising administering to a mammal in need of such therapy an effective amount of the aforementioned thiophene selective adenosine A 1 allosteric enhancer.

  本发明涉及一种式（I）的化合物：1其中：R3选自1-萘基，2-萘基和环烷基苯基的群组；以及R4和R5一起形成一个具有5至10个碳原子的环。此外，本发明提供了一种治疗方法，用于预防或治疗哺乳动物受体中的病理状况或症状，例如人类，其中需要增加血管生成，包括向需要此种治疗的哺乳动物中注射上述噻吩选择性腺苷A1异构增强剂的有效剂量。
• Polymerization catalyst and process for polymerizing alpha-olefins
  申请人：PHILLIPS PETROLEUM COMPANY

  公开号：EP0012397A1

  公开（公告）日：1980-06-25

  Alpha-olefins are polymerized employing a catalyst which forms on mixing a catalyst component A formed by milling together a magnesium halide or manganous halide with selected catalyst adjuvants followed by treatment of the resulting milled product with a halogenated tetravalent titanium compound and combining the product thus formed with a cocatalyst component B comprising at least one of an organoaluminum compound and an organoaluminum monohalide with or without an aromatic ester as a part of the cocatalyst system.

  α-烯烃采用一种催化剂进行聚合，这种催化剂是通过将卤化镁或卤化锰与选定的催化剂辅助剂混合研磨形成催化剂组分 A，然后用卤代四价钛化合物对研磨产物进行处理，并将由此形成的产物与由有机铝化合物和有机铝单卤化物中的至少一种组成的助催化剂组分 B 相结合而形成的，助催化剂体系中可以有芳香族酯，也可以没有芳香族酯。
• Thomas; Couderc, Bulletin de la Societe Chimique de France, 1918, vol. <4> 23, p. 291
  作者：Thomas、Couderc

  DOI：——

  日期：——