tert-butyl 4-(6-(benzyloxy)pyridin-3-yl)piperazine-1-carboxylate | 861884-70-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: tert-butyl 4-(6-(benzyloxy)pyridin-3-yl)piperazine-1-carboxylate
• 英文别名: Tert-butyl 4-[6-(benzyloxy)pyridin-3-YL]piperazine-1-carboxylate；tert-butyl 4-(6-phenylmethoxypyridin-3-yl)piperazine-1-carboxylate
• CAS: 861884-70-0
• 化学式: C₂₁H₂₇N₃O₃
• 分子量: 369.464
• InChiKey: ANQNLPQYVPSVGJ-UHFFFAOYSA-N

物化性质

• 沸点：
  517.2±50.0 °C(Predicted)
• 密度：
  1.162±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  54.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  tert-butyl 4-(6-(benzyloxy)pyridin-3-yl)piperazine-1-carboxylate 在 5%-palladium/activated carbon 、 氢气 、 三氟乙酸 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 生成 5-piperazin-1-ylpyridin-2-ol
  参考文献：
  名称：

  In the Quest for Potent and Selective Malic Enzyme 3 Inhibitors for the Treatment of Pancreatic Ductal Adenocarcinoma

  摘要：

  DOI：

  10.1021/acsmedchemlett.2c00369
• 作为产物：
  描述：

  溴甲苯 在 2-双环己基膦-2',6'-二甲氧基联苯 、 四(三苯基膦)钯 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 生成 tert-butyl 4-(6-(benzyloxy)pyridin-3-yl)piperazine-1-carboxylate
  参考文献：
  名称：

  In the Quest for Potent and Selective Malic Enzyme 3 Inhibitors for the Treatment of Pancreatic Ductal Adenocarcinoma

  摘要：

  DOI：

  10.1021/acsmedchemlett.2c00369

文献信息

• [EN] COMPOUNDS AS INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR<br/>[FR] COMPOSÉS EN TANT QU'INHIBITEURS DU FACTEUR INHIBITEUR DE LA MIGRATION DES MACROPHAGES
  申请人：IMMUNOPHAGE BIOMEDICAL CO LTD

  公开号：WO2020186220A1

  公开（公告）日：2020-09-17

  The present invention provides compounds of Formula (I) shown above and their pharmaceutically acceptable salt, solvates, isomers, or prodrugs, as well as pharmaceutical compositions containing these compounds. Also provided by the invention is a method for treating a disorder mediated by macrophage migration inhibitory factor in a subject, comprising administering to the subject in need thereof a compound or a pharmaceutical composition of this invention.

  本发明提供了上述公式(I)所示的化合物及其药用可接受的盐、溶剂化物、异构体或前药，以及含有这些化合物的药物组合物。本发明还提供了一种用于治疗由巨噬细胞迁移抑制因子介导的疾病的方法，包括向需要治疗的对象施用本发明的化合物或药物组合物。
• Microwave-promoted synthesis of amino-substituted 2-pyridone derivatives via palladium-catalyzed amination reaction
  作者：Jung-Nyoung Heo、Young Seob Song、Bum Tae Kim

  DOI：10.1016/j.tetlet.2005.04.141

  日期：2005.7

  A rapid and efficient synthesis of amino-substituted 2-pyridones was demonstrated by palladium-catalyzed amination reaction under microwave irradiation. This high-speed synthesis provided a number of amino-substituted 2-pyridones from the corresponding bromo-2-benzyloxypyridines via palladium-catalyzed amination followed by hydrogenolysis of benzyl ether.

  微波辐射下钯催化的胺化反应证明了氨基取代的2-吡啶酮的快速有效合成。这种高速合成通过钯催化的胺化反应，然后通过苄基醚的氢解反应，从相应的溴-2-苄氧基吡啶提供了许多氨基取代的2-吡啶酮。
• TRIAZOLE DERIVATIVES HAVING ANTIFUNGAL ACTIVITY, METHOD FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
  申请人：Kim Bum Tae

  公开号：US20100144712A1

  公开（公告）日：2010-06-10

  A triazole derivative of formula 1 or a pharmaceutically acceptable salt, hydrate, solvate or isomer thereof is superior to the conventional antifungal drugs in antifungal activity against a wide spectrum of pathogenic fungi, and has advantageously low toxicity.

  1号公式的三唑衍生物或其药学上可接受的盐、水合物、溶剂合物或异构体，在抗击广谱病原真菌的抗真菌活性方面优于传统的抗真菌药物，并具有低毒性的优势。
• Compounds as Inhibitors of Macrophage Migration Inhibitory Factor
  申请人：FONG Kin Chiu

  公开号：US20220144838A1

  公开（公告）日：2022-05-12

  The present invention provides compounds of Formula (I) shown below and their pharmaceutically acceptable salt, solvates, isomers, or prodrugs, as well as pharmaceutical compositions containing these compounds. Also provided by the invention is a method for treating a disorder mediated by macrophage migration inhibitory factor in a subject, comprising administering to the subject in need thereof a compound or a pharmaceutical composition of this invention.