8-(四氢-2H-吡喃-2-氧基)-辛烷-2-酮 | 64841-41-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 中文名称: 8-(四氢-2H-吡喃-2-氧基)-辛烷-2-酮
• 英文名称: 1-(tetrahydropyran-2-yl)oxy-7-oxooctane
• 英文别名: 1-(tetrahydropyran-2-yloxy)octan-7-one；8-(tetrahydro-2H-pyran-2-yloxy)-octan-2-one；8-hydroxy-2-octanone tetrahydropyranyl ether；8-(Tetrahydro-pyran-2-yloxy)-octan-2-one；8-(oxan-2-yloxy)octan-2-one
• CAS: 64841-41-4
• 化学式: C₁₃H₂₄O₃
• 分子量: 228.332
• InChiKey: PNZGUVNADYZLAF-UHFFFAOYSA-N

物化性质

• 沸点：
  348.9±37.0 °C(Predicted)
• 密度：
  0.97±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  8-(四氢-2H-吡喃-2-氧基)-辛烷-2-酮 在 对甲苯磺酸 作用下， 以 甲醇 、 水 为溶剂， 反应 20.0h， 以85%的产率得到1-羟基-7-辛酮
  参考文献：
  名称：

  Insect pheromones and their analogs. XV. The synthesis of 9-oxodec-2E-enoic acid — A pheromone of the honeybeeApis melliferana

  摘要：

  DOI：

  10.1007/bf00599271
• 作为产物：
  描述：

  7-辛炔-1-醇 在 mercuric triflate-(N,N,N',N'-tetramethylurea)2 、 水 、 4-甲基苯磺酸吡啶 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 52.0h， 生成 8-(四氢-2H-吡喃-2-氧基)-辛烷-2-酮
  参考文献：
  名称：

  Synthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants

  摘要：

  A series of mitochondria-targeted antioxidants comprising a lipophilic triphenylphosphonium cation attached to the antioxidant chroman moiety of vitamin E by an alkyl linker have been prepared. The synthesis of a series of mitochondria-targeted vitamin E derivatives with a range of alkyl linkers gave compounds of different hydrophobicities. This work will enable the dependence of antioxidant defence on hydrophobicity to be determined in vivo. (C) 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license.

  DOI：

  10.1016/j.tet.2015.09.014

文献信息

• 4-oxo-3,4-dihydro-2H-1-benzopyranyloxy alkanoic acid derivatives
  申请人：Hoffmann-La Roche Inc.

  公开号：US04650812A1

  公开（公告）日：1987-03-17

  The invention relates to compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or lower alkyl, R.sup.2 is hydrogen or halogen, R.sup.3 is hydrogen or lower alkyl, R.sup.4 is hydrogen or lower alkyl, R.sup.5 is hydrogen, lower alkyl or aralkyl, X is alkylene and n is an integer from 1 to 6, enantiomers thereof, and, when R.sup.5 is hydrogen, salts thereof with pharmaceutically acceptable bases.

  该发明涉及以下结构的化合物： 其中R.sup.1是氢或较低的烷基，R.sup.2是氢或卤素，R.sup.3是氢或较低的烷基，R.sup.4是氢或较低的烷基，R.sup.5是氢、较低的烷基或芳基烷基，X是烷基，n是1到6的整数，它们的对映体，以及当R.sup.5是氢时，与药用可接受的碱形成的盐。
• 3,4-Dihydro-4-oxo-2H-1-benzopyranyloxy alkanoic acid derivatives
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP0261254A1

  公开（公告）日：1988-03-30

  It has been found that the novel compounds of the formula wherein R¹ is hydrogen or lower alkyl, R² is hydrogen or halogen, R³ is hydrogen or lower alkyl, R⁴ is hydrogen or lower alkyl, R⁵ is hydrogen, lower alkyl or aralkyl, X is alkylene and n is an integer from 1 to 6, the enantiomers thereof and, when R⁵ is hydrogen, the salts thereof with pharmaceutically acceptable bases have antiallergic properties and can accordingly be used as medicaments for the treatment or prevention of allergic conditions. The compounds of formula I can be manufactured by reacting a compound of the formula with a compound of the formula and optionally hydrolyzing the compound thus obtained.

  发现式中的新型化合物 其中 R¹ 是氢或低级烷基，R² 是氢或卤素，R³ 是氢或低级烷基，R⁴ 是氢或低级烷基，R⁵ 是氢、低级烷基或芳烷基，X 是亚烷基，n 是 1 至 6 的整数、 其对映体，以及当 R⁵ 为氢时，其与药学上可接受的碱的盐具有抗过敏特性，因此可用作治疗或预防过敏症的药物。式 I 的化合物可通过将式 I 的化合物与式 I 的化合物反应制得 与式 并可选择水解由此得到的化合物。
• A new access to spiro-isoxazolines derivatives
  作者：M. Smietana、V. Gouverneur、C. Mioskowski

  DOI：10.1016/s0040-4039(98)02452-6

  日期：1999.2

  A series of spiro-isoxazolines 1a-e was prepared in an one-step procedure by treating the corresponding tricarbonyl 3a-e derivatives with hydroxylamine hydrochloride. (C) 1999 Elsevier Science Ltd. All rights reserved.
• Braconnier, M.F.; Braekman, J.C.; Daloze, D., Bulletin des Societes Chimiques Belges, 1985, vol. 94, # 8, p. 605 - 614
  作者：Braconnier, M.F.、Braekman, J.C.、Daloze, D.

  DOI：——

  日期：——
• ——
  作者：G. S. Shakirzyanova、V. S. Abdukakharov、A. A. Abduvakhabov

  DOI：10.1023/a:1012538628323

  日期：——

  Optically active hydroxyesters were prepared using the fungus Aspergillus niger and the yeast Sacharomyces cerevisiae. Substrate is converted highly specifically into optically active isomers with 95% purity. The R-hydroxyester was isolated by asymmetric reduction. (R,R)-Tartaric acid of 60% optical purity was used as an inductor.