2-hydroxy-quinoline-4-carboxylic acid [(2R,4S)-1-(3,5-bis-trifluoromethyl-benzoyl)-2-(4-chloro-benzyl)-piperidin-4-yl]-amide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-hydroxy-quinoline-4-carboxylic acid [(2R,4S)-1-(3,5-bis-trifluoromethyl-benzoyl)-2-(4-chloro-benzyl)-piperidin-4-yl]-amide
• 英文别名: N-[(2R,4S)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-[(4-chlorophenyl)methyl]piperidin-4-yl]-2-oxo-1H-quinoline-4-carboxamide
• 化学式: C₃₁H₂₄ClF₆N₃O₃
• 分子量: 635.993
• InChiKey: AZGBPTHVPSCJPT-XZOQPEGZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  44
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  78.5
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  ((2R,4S)-4-氨基-2-(4-氯苄基)哌啶-1-基)(3,5-二(三氟甲基)苯基)甲酮 在 2-羟基喹啉-4-羧酸 、 1-羟基苯并三唑 、 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 生成 2-hydroxy-quinoline-4-carboxylic acid [(2R,4S)-1-(3,5-bis-trifluoromethyl-benzoyl)-2-(4-chloro-benzyl)-piperidin-4-yl]-amide
  参考文献：
  名称：

  [EN] AROYL-PIPERIDINE DERIVATIVES
  [FR] DERIVES D'AROYL-PIPERIDINE

  摘要：

  该发明涉及一种新型的N-(3,5-二三氟甲基苯甲酰)-2-苄基-4-(喹诺酰氨基)-哌啶类化合物，其化学式为…其中Y和R分别如上所定义，环A未取代或被来自以下群组的取代基单独或多取代，该群组包括低碳烷基、低碳氧基、卤素、硝基和三氟甲基；以及其盐、用途、制备方法和包含根据该发明的化合物的药物组合物。

  公开号：

  WO2004024714A1

文献信息

• Aroyl-piperidine derivatives
  申请人：Veenstra Jacob Siem

  公开号：US20060135558A1

  公开（公告）日：2006-06-22

  The invention relates to novel N-(3,5-bis-trifluoromethyl-benzoyl)-2-benzyl-4-(quinoloylamino)-piperidines of the formula . . . wherein Y and R each are as defined above and the ring A is unsubstituted or mono- or polysubstituted by substituents selected from the group consisting of lower alkyl, lower alkoxy, halogen, nitro and trifluoromethyl; and the salts thereof, to the use thereof, to processes for the preparation thereof and to pharmaceutical compositions comprising a compound according to the invention.

  本发明涉及一种新型的N-(3,5-双三氟甲基苯甲酰)-2-苄基-4-(喹啉基氨基)-哌啶类化合物，其化学式为......其中，Y和R的定义如上所述，环A未取代或被取代为下列取代基之一：较低的烷基、较低的烷氧基、卤素、硝基和三氟甲基；以及其盐、用途、制备方法和含有本发明化合物的制药组合物。
• AROYL-PIPERIDINE DERIVATIVES AND METHOD OF TREATING DISORDERS INDUCED BY SUBSTANCE P
  申请人：Veenstra Siem Jacob

  公开号：US20100120852A1

  公开（公告）日：2010-05-13

  The invention relates to a method of administering N-(3,5-bis-trifluoromethyl-benzoyl)-2-benzyl-4-(quinoloylamino)-piperidines of the formula wherein Y is ═N— or ═N(O)—, R is OH when Y is ═N— and R is H when Y is ═N(O)— and the ring A is unsubstituted or mono- or poly-substituted by substituents selected from the group consisting of lower alkyl, lower alkoxy, halogen, nitro and trifluoromethyl, provided that when R is OH and Y is ═N— the ring A is not unsubstituted, for the treatment of disorders induced by substance P, such as: pain, migraines, anxiety, vomiting, schizophrenia, depression; motor disorders such as Parkinson's disease, inflammatory diseases such a rheumatoid arthritis, iritis and conjunctivitis, diseases of the respiratory organs such as asthma and chronic bronchitis, diseases of the gastrointestinal system such as ulcerative colitis and Crohn's disease, and hypertension.

  本发明涉及一种治疗由物质P引起的疾病的方法，包括疼痛，偏头痛，焦虑，呕吐，精神分裂症，抑郁症；运动障碍如帕金森病，炎症性疾病如类风湿性关节炎，虹膜炎和结膜炎，呼吸器官疾病如哮喘和慢性支气管炎，胃肠系统疾病如溃疡性结肠炎和克罗恩病，以及高血压的N-（3,5-双三氟甲基苯甲酰）-2-苄基-4-（喹诺啉氨基）哌啶类化合物的给药方法，其中Y为═N-或═N（O）-，当Y为═N-时，R为OH，当Y为═N（O）-时，R为H，环A未取代或被来自以下取代基组的取代基单独或多重取代，所述取代基组包括较低的烷基，较低的烷氧基，卤素，硝基和三氟甲基，但当R为OH且Y为═N-时，环A未取代。
• Aroyl-piperidine derivatives and method of treating disorders induced by substance P
  申请人：Novartis AG

  公开号：US08193218B2

  公开（公告）日：2012-06-05

  The invention relates to a method of administering N-(3,5-bis-trifluoromethyl-benzoyl)-2-benzyl-4-(quinoloylamino)-piperidines of the formula wherein Y is ═N— or ═N(O)—, R is OH when Y is ═N— and R is H when Y is ═N(O)— and the ring A is unsubstituted or mono- or poly-substituted by substituents selected from the group consisting of lower alkyl, lower alkoxy, halogen, nitro and trifluoromethyl, provided that when R is OH and Y is ═N— the ring A is not unsubstituted, for the treatment of disorders induced by substance P, such as: pain, migraines, anxiety, vomiting, schizophrenia, depression; motor disorders such as Parkinson's disease, inflammatory diseases such a rheumatoid arthritis, iritis and conjunctivitis, diseases of the respiratory organs such as asthma and chronic bronchitis, diseases of the gastrointestinal system such as ulcerative colitis and Crohn's disease, and hypertension.

  本发明涉及一种治疗由物质P引起的疾病的方法，例如：疼痛、偏头痛、焦虑、呕吐、精神分裂症、抑郁症；运动障碍，如帕金森病；炎症性疾病，如类风湿性关节炎、虹膜炎和结膜炎；呼吸器官疾病，如哮喘和慢性支气管炎；胃肠系统疾病，如溃疡性结肠炎和克罗恩病以及高血压的N-（3,5-双三氟甲基苯甲酰）-2-苄基-4-（喹啉基氨基）-哌啶衍生物的给药方法。其中，Y为═N-或═N（O）-，当Y为═N-时，R为OH；当Y为═N（O）-时，R为H；环A为未取代或取代的低烷基、低烷氧基、卤素、硝基和三氟甲基中选取的取代基，但当R为OH且Y为═N-时，环A不为未取代。
• PHARMACEUTICAL FORMULATION
  申请人：Avera Pharmaceuticals, Inc.

  公开号：EP2124949A1

  公开（公告）日：2009-12-02
• US7678814B2
  申请人：——

  公开号：US7678814B2

  公开（公告）日：2010-03-16