[(3-methyl-2,6-diphenyloxan-4-ylidene)amino]thiourea | 1204707-47-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: [(3-methyl-2,6-diphenyloxan-4-ylidene)amino]thiourea
• CAS: 1204707-47-0
• 化学式: C₁₉H₂₁N₃OS
• 分子量: 339.461
• InChiKey: DVBPZMAILSKFLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.71
• 重原子数：
  24.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  59.64
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  [(3-methyl-2,6-diphenyloxan-4-ylidene)amino]thiourea 在 双氧水 作用下， 以 氯仿 为溶剂， 反应 6.0h， 以82%的产率得到7,9-diphenyl-6-methyl-1,2,4-triaza-8-oxa-spiro(4.5)decan-3-thione
  参考文献：
  名称：

  Synthesis, characterisation and antimicrobial activities of novel 7,9-diphenyl-1,2,4-triaza-8-oxa-spiro[4.5]-decan-3-thiones

  摘要：

  Some new 7,9-diaryl-1,2,4-triaza-8-oxa-spiro[4.5]-decan-3-thiones has been synthesised and their antibacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi, and antifungal activity against Candida albicans, Rhizopus sp., Aspergillus flavus and Aspergillus niger were examined. Compounds 14 and 15 against E. coli and S. typhi showed marked antibacterial activity. Similarly, compounds 13 and 15 against Rhizopus sp. and 13 and 14 against A. flavus exerted significant antifungal activities.

  DOI：

  10.1007/s00044-010-9348-8
• 作为产物：
  描述：

  苯甲醛 在 盐酸 、 potassium hydroxide 作用下， 以 甲醇 、 乙醇 、 水 为溶剂， 反应 363.0h， 生成 [(3-methyl-2,6-diphenyloxan-4-ylidene)amino]thiourea
  参考文献：
  名称：

  Synthesis, characterisation and antimicrobial activities of novel 7,9-diphenyl-1,2,4-triaza-8-oxa-spiro[4.5]-decan-3-thiones

  摘要：

  Some new 7,9-diaryl-1,2,4-triaza-8-oxa-spiro[4.5]-decan-3-thiones has been synthesised and their antibacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi, and antifungal activity against Candida albicans, Rhizopus sp., Aspergillus flavus and Aspergillus niger were examined. Compounds 14 and 15 against E. coli and S. typhi showed marked antibacterial activity. Similarly, compounds 13 and 15 against Rhizopus sp. and 13 and 14 against A. flavus exerted significant antifungal activities.

  DOI：

  10.1007/s00044-010-9348-8

文献信息

• Spectral characterization and crystal structure of 5-spiro-(3-methyl-2,6-diphenyltetrahydropyran-4-yl)-4,5-dihydro-[1,3,4]thiadiazole
  作者：S. Umamatheswari、S. Kabilan

  DOI：10.1016/j.molstruc.2009.09.016

  日期：2009.12

  The synthesis of now 1,3,4-thiadiazoline derived from 3-methyl-2,6-diphenyltetrahydropyran-4 one, via the corresponding thiosemicarbazone, is described The synthesis. spectral characterization and crystal structure of 5-spiro-1,3,4-thiadiazoline of 2.6-diphenyl-3-methylpyran is reported. Spectral techniques employed include H-1 NMR, C-13 NMR, HOMOCOSY, HSQC, HMBC, NOESY correlation techniques, mass and IR. The conformation of the compound is established on the basis of H-1 NMR spectral data, MOPAC calculation and the single crystal X-ray analysis. (C) 2009 Elsevier B.V. All rights reserved.
• Synthesis, characterisation and antimicrobial activities of novel 7,9-diphenyl-1,2,4-triaza-8-oxa-spiro[4.5]-decan-3-thiones
  作者：Senthamaraikannan Kabilan、Seeman Umamatheswari

  DOI：10.1007/s00044-010-9348-8

  日期：2011.6

  Some new 7,9-diaryl-1,2,4-triaza-8-oxa-spiro[4.5]-decan-3-thiones has been synthesised and their antibacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi, and antifungal activity against Candida albicans, Rhizopus sp., Aspergillus flavus and Aspergillus niger were examined. Compounds 14 and 15 against E. coli and S. typhi showed marked antibacterial activity. Similarly, compounds 13 and 15 against Rhizopus sp. and 13 and 14 against A. flavus exerted significant antifungal activities.