N-(7-(dimethylamino)-3H-phenoxazin-3-ylidene)-N-ethylethanaminium

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: N-(7-(dimethylamino)-3H-phenoxazin-3-ylidene)-N-ethylethanaminium
• 英文别名: [7-(Diethylamino)phenoxazin-3-ylidene]-dimethylazanium
• 化学式: C₁₈H₂₂N₃O
• 分子量: 296.392
• InChiKey: KOLSUHDQRBUZMN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  27.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-羟基-N,N-二乙基苯胺 在 盐酸 、 高氯酸 、 sodium hydride 、 sodium nitrite 作用下， 以 四氢呋喃 、 水 、 异丙醇 、 mineral oil 为溶剂， 反应 3.17h， 生成 N-(7-(dimethylamino)-3H-phenoxazin-3-ylidene)-N-ethylethanaminium
  参考文献：
  名称：

  [EN] NERVE-SPECIFIC FLUOROPHORE FORMULATIONS FOR DIRECT AND SYSTEMIC ADMINISTRATION
  [FR] FORMULATIONS DE FLUOROPHORE SPÉCIFIQUE AUX NERFS POUR ADMINISTRATION DIRECTE ET SYSTÉMIQUE

  摘要：

  描述了用于直接或全身给药的神经特异性荧光素配方。这些配方可用于荧光引导手术（FGS），帮助在外科手术干预期间保护神经。

  公开号：

  WO2020033435A1

文献信息

• [EN] NEAR-INFRARED NERVE-SPARING FLUOROPHORES<br/>[FR] FLUOROPHORES ÉPARGNANT LES NERFS EN PROCHE INFRAROUGE
  申请人：UNIV OREGON HEALTH & SCIENCE

  公开号：WO2020023911A3

  公开（公告）日：2020-03-26
• PHOTOPOLYMER FORMULATION FOR PRODUCING HOLOGRAPHIC MEDIA HAVING HIGHLY CROSSLINKED MATRIX POLYMERS
  申请人：Berneth Horst

  公开号：US20130224634A1

  公开（公告）日：2013-08-29

  The invention relates to a photopolymer formulation comprising a polyol component, a polyisocyanate component, a writing monomer, and a photoinitiator, containing a coinitiator and a dye having the formula F An, where F stands for a cationic dye and An″ stands for an anion, wherein the dye having the formula F An comprises a water absorption of =5%. The invention further relates to a holographic medium, in particular in the form of a film, containing a photopolymer formulation according to the invention, to the use of such a medium for recording holograms, and to a special dye that can be used in the photopolymer formulation according to the invention.
• NEAR-INFRARED FLUORESCENT CONTRAST BIOIMAGING AGENTS AND METHODS OF USE THEREOF
  申请人：BETH ISRAEL DEACONESS MEDICAL CENTER

  公开号：US20160263249A1

  公开（公告）日：2016-09-15

  The instant invention provides near-infrared fluorescent biological contrast agents and methods of using them.
• 3,6-DISUBSTITUTED XANTHYLIUM SALTS
  申请人：WisTa Laboratories Ltd.

  公开号：US20170088534A1

  公开（公告）日：2017-03-30

  Described are a compound of formula (II) or (III): The compounds are effective in the treatment of disease, including a tauopathy condition or a disease of tau protein aggregation.
• NERVE-SPECIFIC FLUOROPHORE FORMULATIONS FOR DIRECT AND SYSTEMIC ADMINISTRATION
  申请人：OREGON HEALTH & SCIENCE UNIVERSITY

  公开号：US20210236657A1

  公开（公告）日：2021-08-05

  Nerve-specific fluorophore formulations for direct or systemic administration are described. The formulations can be used in fluorescence-guided surgery (FGS) to aid in nerve preservation during surgical interventions.