4-nitro-[2]naphthoic acid | 5773-65-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-nitro-[2]naphthoic acid
• 英文别名: 4-Nitro-[2]naphthoesaeure；4-Nitro-2-naphthoesaeure；4-Nitronaphthalene-2-carboxylic acid
• CAS: 5773-65-9
• 化学式: C₁₁H₇NO₄
• 分子量: 217.181
• InChiKey: QSKMHFGBHYAKRU-UHFFFAOYSA-N

物化性质

• 熔点：
  270 °C (decomp)
• 沸点：
  398.3±30.0 °C(Predicted)
• 密度：
  1.468±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  喹啉 、 4-nitro-[2]naphthoic acid 、 alkaline earth salt of/the/ methylsulfuric acid 生成 硝基萘
  参考文献：
  名称：

  Egg Production, Fertility, and Hatchability of Breeder Hens Receiving Dietary Phytase

  摘要：

  An experiment was conducted to determine whether supplemental dietary phytase could support egg production, egg shell quality, fertility, and hatchability in broiler breeder hens on a diet with marginal available phosphorus. During the production period, 27 to 60 wk of age, individually caged broiler breeder hens; were fed four diets with two available phosphorus (AP) concentrations (0.1 and 0.3%) and two phytase levels [0 and 300 phytase units (FTU)/kg]. Phytase increased overall hen-day egg production by 9.8%, as compared with hens consuming a low phosphorus diet without added phytase. Addition of phytase significantly reduced hen mortality regardless of AP levels. Phytase improved bone mineral content and bone density of hens at both AP levels. Supplemental phytase had no significant effect on egg weight or egg specific gravity. The results suggest the possibility of a detrimental interaction of phytase with the 0.1 AP level on hatchability.

  DOI：

  10.1093/japr/12.3.264
• 作为产物：
  描述：

  3-amino-4-nitro-[2]naphthoic acid 在 硫酸 、 溶剂黄146 、 sodium nitrite 作用下， 生成 4-nitro-[2]naphthoic acid
  参考文献：
  名称：

  Egg Production, Fertility, and Hatchability of Breeder Hens Receiving Dietary Phytase

  摘要：

  An experiment was conducted to determine whether supplemental dietary phytase could support egg production, egg shell quality, fertility, and hatchability in broiler breeder hens on a diet with marginal available phosphorus. During the production period, 27 to 60 wk of age, individually caged broiler breeder hens; were fed four diets with two available phosphorus (AP) concentrations (0.1 and 0.3%) and two phytase levels [0 and 300 phytase units (FTU)/kg]. Phytase increased overall hen-day egg production by 9.8%, as compared with hens consuming a low phosphorus diet without added phytase. Addition of phytase significantly reduced hen mortality regardless of AP levels. Phytase improved bone mineral content and bone density of hens at both AP levels. Supplemental phytase had no significant effect on egg weight or egg specific gravity. The results suggest the possibility of a detrimental interaction of phytase with the 0.1 AP level on hatchability.

  DOI：

  10.1093/japr/12.3.264

文献信息

• Adcock,W.; Wells,P.R., Australian Journal of Chemistry, 1965, vol. 18, p. 1351 - 1364
  作者：Adcock,W.、Wells,P.R.

  DOI：——

  日期：——
• 4-MERCAPTOPYRROLIDINE DERIVATIVES AS FARNESYL TRANSFERASE INHIBITORS
  申请人：ZENECA LIMITED

  公开号：EP0842151A1

  公开（公告）日：1998-05-20
• US6232338B1
  申请人：——

  公开号：US6232338B1

  公开（公告）日：2001-05-15
• US6541491B1
  申请人：——

  公开号：US6541491B1

  公开（公告）日：2003-04-01
• [EN] 4-MERCAPTOPYRROLIDINE DERIVATIVES AS FARNESYL TRANSFERASE INHIBITORS<br/>[FR] DERIVES DE 4-MERCAPTOPYRROLIDINE EN TANT QU'INHIBITEURS DE FARNESYLE TRANSFERASE
  申请人：ZENECA LIMITED

  公开号：WO1997006138A1

  公开（公告）日：1997-02-20

  (EN) Pharmaceutical compositions comprising an inhibitor of ras farnesylation of formula (I) wherein, R1 is for example H and further values as defined in the specification; R2 is for example H and further values as defined in the specification; R3 is for example H or a substituent having values as defined in the specification; p is 0-3 in which R3 values can be the same or different; L is a linking moiety for example -CO-NH2- and further values as defined in the specification; A is selected from phenyl; naphthyl; a 5-10 membered monocyclic or bicyclic heteroaryl ring containing up to 5 heteroatoms where the heteroatoms are independently selected from O, N and S; or a -S-S- dimer thereof when R2=H; or an enantiomer, diastereoisomer, pharmaceutically acceptable salt, prodrug or solvate thereof together with a pharmaceutically acceptable diluent or carrier. A particular use is cancer therapy.(FR) Compositions pharmaceutiques comprenant un inhibiteur de la farnésylation des gènes du sarcome du rat (ras) représenté par la formule (I), dans laquelle R1 désigne par exemple H et d'autres valeurs précisées dans la description; R2 désigne par exemple H et d'autres valeurs précisées dans la description; R3 désigne H ou un substituant ayant les valeurs précisées dans la description; p vaut entre 0 et 3 là où les valeurs R3 peuvent être les mêmes ou différentes; L désigne une fraction de liaison par exemple -CO-NH2- et d'autres valeurs précisées dans la description; A est choisi parmi un phényle, un naphtyle, un noyau hétéroaryle monocyclique ou bicyclique de 5 à 10 chaînons comprenant un maximum de 5 hétéroatomes dans lequel les hétéroatomes sont sélectionnés parmi O, N et S, ou un de ses dimères -S-S- lorsque R2 est égal à H, ou un de ses énantiomères, diastéréo-isomères, sels pharmaceutiquement acceptables, médicaments précurseurs ou solvates accompagnés d'un diluant ou véhicule pharmaceutiquement acceptable. Il est destiné notamment au traitement anticancéreux.