cyano-4-ethylbiphenyl

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: cyano-4-ethylbiphenyl
• 英文别名: 2-Cyano-4-ethylbiphenyl；5-Ethyl-2-phenylbenzonitrile
• 化学式: C₁₅H₁₃N
• 分子量: 207.275
• InChiKey: APUUDLWPECGIOF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  cyano-4-ethylbiphenyl 、 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 四氯化碳 为溶剂， 生成 4-(1-bromoethyl)-2-cyanobiphenyl
  参考文献：
  名称：

  Condensed imidazole derivatives and processes for preparation thereof

  摘要：

  该化合物的结构式如下：其中R¹为低碳烷基、卤代低碳烷基、环状低碳烷基或低碳硫代基，R²为氢或亚胺保护基，R³为氢或卤素，A为低碳烷基，是一个结构式中的基团：其中X¹、X²、X³和X⁴分别为N或CR⁴，其中R⁴为氢、低碳烷基、低碳氧基、卤素、卤代低碳烷基、酯化羧基、卤代低碳氧基或羟基，但至少其中一个为N，并且其药学上可接受的盐，以及其制备方法和包含它们作为活性成分与药学上可接受的载体或赋形剂混合的药物组合物。

  公开号：

  EP0426021A1

文献信息

• [EN] PYRAZOLE DERIVATIVES, COMPOSITIONS AND THERAPEUTIC USE THEREOF<br/>[FR] DÉRIVÉS DE PYRAZOLE, COMPOSITIONS LES COMPRENANT ET LEUR UTILISATION THÉRAPEUTIQUE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2017191098A1

  公开（公告）日：2017-11-09

  Compounds of Formula (I): and salts thereof, and methods of use as Janus kinase inhibitors are described herein.

  化合物的化学式（I）及其盐，以及作为Janus激酶抑制剂的使用方法在此处描述。
• PYRAZOLE DERIVATIVES, COMPOSITIONS AND THERAPEUTIC USE THEREOF
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3452464B1

  公开（公告）日：2021-12-15
• ORGANIC COMPOUND, ELECTRONIC COMPONENT AND ELECTRONIC APPARATUS
  申请人：Shaanxi Lighte Optoelectronics Material Co., Ltd.

  公开号：US20220220084A1

  公开（公告）日：2022-07-14

  Provided in the present disclosure is an organic compound, which relates to the technical field of organic materials. In the compound of the present disclosure, an electron-deficient nitrogen-containing heteroaryl and cyano are linked to adamantly, so that the LUMO energy level is deepened, thereby electron mobility is further improved. Further provided in the present disclosure are an electronic component and electronic apparatus comprising the described organic compound. The organic compound can improve the electron transport performance of electronic components. When used as an electron transport layer of an organic light-emitting electroluminescent device, the compound can improve the luminous efficiency and service life of the device and reduce the working voltage.
• Condensed imidazole derivatives and processes for preparation thereof
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0426021A1

  公开（公告）日：1991-05-08

  A compound of the formula : wherein R¹ is lower alkyl, halo(lower)alkyl, cyclo(lower)alkyl or lower alkylthio, R² is hydrogen or imino-protective group, R³ is hydrogen or halogen, A is lower alkylene, and is a group of the formula : in which X¹, X², X³ and X⁴ are each N or CR⁴, in which R⁴ is hydrogen, lower alkyl, lower alkoxy, halogen, halo(lower)alkyl, esterified carboxy, halo(lower)alkoxy or hydroxy, provided that at least one of X¹, X², X³ and X⁴ is N, and pharmaceutically acceptable salts thereof, processes for their preparation and pharmaceutical compositions comprising them as an active ingredient in admixture with a pharmaceutically acceptable carrier or excipient.

  该化合物的结构式如下：其中R¹为低碳烷基、卤代低碳烷基、环状低碳烷基或低碳硫代基，R²为氢或亚胺保护基，R³为氢或卤素，A为低碳烷基，是一个结构式中的基团：其中X¹、X²、X³和X⁴分别为N或CR⁴，其中R⁴为氢、低碳烷基、低碳氧基、卤素、卤代低碳烷基、酯化羧基、卤代低碳氧基或羟基，但至少其中一个为N，并且其药学上可接受的盐，以及其制备方法和包含它们作为活性成分与药学上可接受的载体或赋形剂混合的药物组合物。