(9H-fluoren-9-yl)methyl N-(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)carbamate | 308241-31-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: (9H-fluoren-9-yl)methyl N-(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)carbamate
• 英文别名: 9H-fluoren-9-ylmethyl N-[3-[2-[2-(3-aminopropoxy)ethoxy]ethoxy]propyl]carbamate
• CAS: 308241-31-8
• 化学式: C₂₅H₃₄N₂O₅
• 分子量: 442.555
• InChiKey: RBOKPWRAYLKQAK-UHFFFAOYSA-N

物化性质

• 沸点：
  621.9±50.0 °C(Predicted)
• 密度：
  1.146±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  32
• 可旋转键数：
  16
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  92
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (9H-fluoren-9-yl)methyl N-(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)carbamate 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 、 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.5h， 生成 [3-(2-{2-[3-({(3-{2-[2-(3-Amino-propoxy)-ethoxy]-ethoxy}-propylamino)-[(Z)-2,2,4,6,7-pentamethyl-2,3-dihydro-benzofuran-5-sulfonylimino]-methyl}-amino)-propoxy]-ethoxy}-ethoxy)-propyl]-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Solution- and Solid-Phase Syntheses of Guanidine-Bridged, Water-Soluble Linkers for Multivalent Ligand Design

  摘要：

  Efficient syntheses of guanidine-bridged poly(ethylene glycol) linkers of various lengths in fully protected form are reported for both solution- and solid-phase protocols. The application of such linkers in the construction of water-soluble and high-affinity multivalent ligands against cholera toxin is demonstrated. Synthetic intermediates for multivalent ligands as large as 20 kDa in molecular weight have been assembled using presynthesized linkers. The final ligands are highly water-soluble, thus enabling proper biophysical characterization.

  DOI：

  10.1021/ol049835v
• 作为产物：
  描述：

  在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.33h， 生成 (9H-fluoren-9-yl)methyl N-(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)carbamate
  参考文献：
  名称：

  Solution- and Solid-Phase Syntheses of Guanidine-Bridged, Water-Soluble Linkers for Multivalent Ligand Design

  摘要：

  Efficient syntheses of guanidine-bridged poly(ethylene glycol) linkers of various lengths in fully protected form are reported for both solution- and solid-phase protocols. The application of such linkers in the construction of water-soluble and high-affinity multivalent ligands against cholera toxin is demonstrated. Synthetic intermediates for multivalent ligands as large as 20 kDa in molecular weight have been assembled using presynthesized linkers. The final ligands are highly water-soluble, thus enabling proper biophysical characterization.

  DOI：

  10.1021/ol049835v

文献信息

• [EN] MACROCYCLIC PEPTIDES USEFUL AS IMMUNOMODULATORS<br/>[FR] PEPTIDES MACROCYCLIQUES UTILES COMME IMMUNOMOLDULATEURS
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2016077518A1

  公开（公告）日：2016-05-19

  The present disclosure provides compounds which are immunomodulators and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.

  本公开提供了一些免疫调节剂化合物，因此对于改善各种疾病，包括癌症和传染病，具有用处。
• Second generation DNA-encoded dynamic combinatorial chemical libraries
  作者：Francesco V. Reddavide、Meiying Cui、Weilin Lin、Naiqiang Fu、Stephan Heiden、Helena Andrade、Michael Thompson、Yixin Zhang

  DOI：10.1039/c9cc01429b

  日期：——

  We present a DNA-encoded chemical library, which allows dynamic selection followed by ligation of the encoding strands. As a chemical approach to mimic the genetic recombination process of adaptive immunity, the technology led to an enhanced enrichment factor and signal-to-noise ratio compared to static libraries.

  我们提出了一种DNA编码的化学文库，该库允许动态选择，然后连接编码链。作为模仿适应性免疫的基因重组过程的化学方法，与静态文库相比，该技术导致增强的富集因子和信噪比。
• Site-specific immobilization of endoglycosidases for streamlined chemoenzymatic glycan remodeling of antibodies
  作者：Tiezheng Li、Chao Li、David N. Quan、William E. Bentley、Lai-Xi Wang

  DOI：10.1016/j.carres.2018.02.007

  日期：2018.3

  antibodies using an endoglycosidase and its mutant is emerging as an attractive approach for producing homogeneous antibody glycoforms. We report in this paper a site-specific covalent immobilization of the endoglycosidases (Endo-S2 and its glycosynthase mutant D184M) using a recombinant microbial transglutaminase (MTG) and evaluation of the immobilized enzymes in deglycosylation and glycosylation of a therapeutic

  使用内切糖苷酶及其突变体对抗体进行化学酶促聚糖重塑是一种有吸引力的方法，可用于生产均质抗体糖型。我们在本文中报告了使用重组微生物转谷氨酰胺酶（MTG）的糖苷内切酶（Endo-S2及其糖合酶突变体D184M）的位点特异性共价固定化和固定化酶在治疗性抗体的去糖基化和糖基化中的评估。通过在重组酶的C末端引入Q标签，然后通过MTG催化的转谷氨酰胺酶将酶与含伯胺的固体支持物偶联，可以实现位点特异性共价固定。使用利妥昔单抗作为模型系统，我们发现通过这种方法固定的Endo-S2野生型和D184M糖合酶突变体在两步抗体聚糖重构中产生均质抗体糖型的过程中非常有效。特别地，使用共价固定的酶可以有效地避免中间纯化的需要，并消除了野生型酶用于产物水解的残留污染，从而简化了抗体的化学酶促Fc聚糖重塑。
• AMINO DIACIDS CONTAINING PEPTIDE MODIFIERS
  申请人：CHEMICAL & BIOPHARMACEUTICAL LABORATORIES OF PATRAS S.A.

  公开号：US20160207957A1

  公开（公告）日：2016-07-21

  The present invention relates to peptide modifier compounds of Formula (1), or a salt thereof, wherein: a is an integer from 1 to 10, more preferably from 1 to 3; b is an integer from 0 to 7; Z is a terminal group and Y is a bivalent group. Further aspects of the invention relate to intermediates in the preparation of compounds of Formula (1), and the use of compounds of Formula 1 in the synthesis of peptide derivatives.

  本发明涉及式（1）的肽修饰化合物或其盐，其中：a为1至10的整数，更好地为1至3；b为0至7的整数；Z为末端基团，Y为双价基团。本发明的其他方面涉及制备式（1）化合物的中间体以及使用式1化合物合成肽衍生物。
• Immunomodulators
  申请人：Bristol-Myers Squibb Company

  公开号：US20160137696A1

  公开（公告）日：2016-05-19

  The present disclosure provides compounds which are immunomodulators and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.

  本公开提供具有免疫调节作用的化合物，因此可用于改善各种疾病，包括癌症和传染病。