4-(2-amino-ethyl)-2,6-dinitro-phenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-(2-amino-ethyl)-2,6-dinitro-phenol
• 英文别名: 4-(2-Amino-aethyl)-2,6-dinitro-phenol；3.5-Dinitro-4-oxy-β-phenaethylamin；3.5-Dinitro-tyramin；4-(2-Aminoethyl)-2,6-dinitrophenol；4-(2-aminoethyl)-2,6-dinitrophenol
• 化学式: C₈H₉N₃O₅
• 分子量: 227.177
• InChiKey: BPSIEFFUFTWGEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  138
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-(2-amino-ethyl)-2,6-dinitro-phenol 、 alkaline earth salt of/the/ methylsulfuric acid 生成 3,5-二硝基-4-羟基苯甲酸
  参考文献：
  名称：

  Waser; Sommer, Helvetica Chimica Acta, 1923, vol. 6, p. 60

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(4-甲氧苯基)乙胺 在 硝酸 、 硝酸脲 、 溶剂黄146 作用下， 生成 4-(2-amino-ethyl)-2,6-dinitro-phenol
  参考文献：
  名称：

  Pro-atrial natriuretic peptide hormone from right atria is correlated with cardiac depression in septic patients

  摘要：

  N-terminal pro-atrial natriuretic peptide [proANP(1-98)] has been extensively investigated in patients with chronic heart failure and ishemic heart disease. It is found to be a better marker of cardiac dysfunction than atrial natriuretic peptide (ANP). The possible involvement of proANP(1-98) in cardiac depression caused by sepsis has not been studied yet. Therefore, we analyzed atrial plasma concentration of proANP(1-98) in 17 septic patients with hemodynamic variables measured or calculated using pulmonary artery catheter, The results of altogether 96 measurements show a significant negative correlation of proANP(1-98) and cardiac index (p<0.024), oxygen delivery (p<0.03) and oxygen consumption (p<0.03), There is also a positive correlation with pulmonary vascular resistance (p<0.03). ProANP(1-98) is significantly higher in patients who developed acute respiratory distress syndrome (ARDS) (p<0.001), This study implies that proANP(1-98) is a possible novel hormone marker of cardiac depression caused by sepsis that could be used for prediction of ARDS. (J. Endocrinol. Invest, 24: RC22-RC24, 2001) (C) 2001, Editrice Kurtis.

  DOI：

  10.1007/bf03343878

文献信息

• Processes and host cells for genome, pathway, and biomolecular engineering
  申请人：enEvolv, Inc.

  公开号：US10370654B2

  公开（公告）日：2019-08-06

  The present disclosure provides compositions and methods for genomic engineering.

  本公开提供了基因组工程的组合物和方法。
• Cloetta; Wuensche, Naunyn-Schmiedebergs Archiv fur Experimentelle Pathologie und Pharmakologie, 1923, vol. 96, p. 313
  作者：Cloetta、Wuensche

  DOI：——

  日期：——
• PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING
  申请人：ENEVOLV, INC.

  公开号：US20160186168A1

  公开（公告）日：2016-06-30

  The present disclosure provides compositions and methods for genomic engineering.
• US9944925B2
  申请人：——

  公开号：US9944925B2

  公开（公告）日：2018-04-17
• Pro-atrial natriuretic peptide hormone from right atria is correlated with cardiac depression in septic patients
  作者：Branka Mazul-Sunko、N. Zarkovic、N. Vrkic、R. Klinger、M. Peric、M. Bekavac-Beslin、M. Novkoski、A. Krizmanic、A. Gvozdenovic、E. Topic

  DOI：10.1007/bf03343878

  日期：2001.7

  N-terminal pro-atrial natriuretic peptide [proANP(1-98)] has been extensively investigated in patients with chronic heart failure and ishemic heart disease. It is found to be a better marker of cardiac dysfunction than atrial natriuretic peptide (ANP). The possible involvement of proANP(1-98) in cardiac depression caused by sepsis has not been studied yet. Therefore, we analyzed atrial plasma concentration of proANP(1-98) in 17 septic patients with hemodynamic variables measured or calculated using pulmonary artery catheter, The results of altogether 96 measurements show a significant negative correlation of proANP(1-98) and cardiac index (p<0.024), oxygen delivery (p<0.03) and oxygen consumption (p<0.03), There is also a positive correlation with pulmonary vascular resistance (p<0.03). ProANP(1-98) is significantly higher in patients who developed acute respiratory distress syndrome (ARDS) (p<0.001), This study implies that proANP(1-98) is a possible novel hormone marker of cardiac depression caused by sepsis that could be used for prediction of ARDS. (J. Endocrinol. Invest, 24: RC22-RC24, 2001) (C) 2001, Editrice Kurtis.