diethyl 4-[2-(4-aminobutoxy)-5-nitrophenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diethyl 4-[2-(4-aminobutoxy)-5-nitrophenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• 化学式: C₂₃H₃₁N₃O₇
• 分子量: 461.515
• InChiKey: PGADVRVMEWQDRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  33
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  146
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  diethyl 4-[2-(4-aminobutoxy)-5-nitrophenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 、 苯基缩水甘油醚 在 chlroform-methanol 、 乙醇 作用下， 以 甲醇 为溶剂， 反应 16.0h， 以to give 2.2 g of diethyl 4-[2-[4-(2-hydroxy-3-phenoxypropylamino)butoxy]-5-nitrophenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate的产率得到diethyl 4-[2-[4-(2-hydroxy-3-phenoxypropylamino)butoxy]-5-nitrophenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  参考文献：
  名称：

  Dihydropyridine compounds and pharmaceutical compositions containing them

  摘要：

  以下是通式（I）的二氢吡啶化合物或其盐：##STR1## 其中R.sup.1和R.sup.2，相同或不同，各代表C.sub.1到C.sub.10烷基，被氧原子中断的较低烷基，或被C.sub.3到C.sub.6脂环基取代的较低烷基;R.sup.3和R.sup.4，相同或不同，各代表较低烷基;R.sup.5和R.sup.6，相同或不同，各代表氢原子、硝基、卤素原子、较低烷基、较低烷氧基、较低烷基硫基、较低烷基磺酰基或较低烷基亚磺酰基;R.sup.7和R.sup.8，相同或不同，各代表氢原子、卤素原子、氰基、较低烷氧基或较低烷基酰胺基，或R.sup.7可以与R.sup.8结合，与相邻的苯基一起形成萘基;A代表单键、乙烯基（--CH.dbd.CH--）或乙炔基（--C.dbd.C--）;B代表单键或--CH.sub.2 O--;m和n，相同或不同，各代表0或1到5的整数。这些化合物对于治疗各种心血管疾病非常有用，因为它们具有Ca.sup.2+ -拮抗和肾上腺素β受体阻滞活性。

  公开号：

  US04727082A1

文献信息

• Dihydropyridine compounds, their production, and pharmaceutical compositions containing them
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP0167371A2

  公开（公告）日：1986-01-08

  The invention provides a dihydropyridine compound of the following general formular (I) or a salt thereof: wherein R' and R2 are the same or different and selected from C, to C10 alkyl groups, C, to C5 alkyl groups interrupted by oxygen atom(s), and C, to C5 alkyl groups substituted by C3 to C6 alicyclic group(s); R3 and R4 are the same or different C, to C5 alkyl groups; R5 and R6 are the same or different and selected from hydrogen and halogen atoms and nitro, C, to C5 alkyl, C, to C5 alkoxy, C, to C5 alkylthio, C, to C5 alkylsulfonyl and C, to C5 alkylsulfinyl groups; R7 and R8 are the same or different and are selected from hydrogen and halogen atoms and cyano, C, to C5 alkoxy and C, to C5 alkanoylamino groups or combine to form, with the adjacent phenyl group, a naphthyl group; A represents a single bond, or a vinylene (-CH=CH-) or ethynylene group (-C≡C-); B represents a single bond or -CH20-; and m and n are the same or different and selected from 0 and integers of 1 to 5, and methods of making such a compound. The compounds may be used for treatment or prevention of ischemic heart-disease and cardiovascular disorders and may show both Ca2+-antagonistic action and adrenergic betareceptor

  本发明提供了以下通式（I）的二氢吡啶化合物或其盐： 其中R'和R2相同或不同，选自C～C10烷基、被氧原子间断的C～C5烷基和被C3～C6脂环基取代的C～C5烷基；R3 和 R4 是相同或不同的 C 至 C5 烷基；R5 和 R6 是相同或不同的选自氢和卤素原子及硝基、C 至 C5 烷基、C 至 C5 烷氧基、C 至 C5 烷硫基、C 至 C5 烷磺酰基和 C 至 C5 烷基亚磺酰基的基团；R7 和 R8 相同或不同，选自氢和卤素原子、氰基、C, 至 C5 烷氧基和 C, 至 C5 烷酰胺基，或与相邻苯基结合形成萘基；A代表单键，或乙烯基（-CH=CH-）或乙炔基（-C≡C-）；B代表单键或-CH20-；m和n相同或不同，选自0和1至5的整数，以及制造这种化合物的方法。这些化合物可用于治疗或预防缺血性心脏病和心血管疾病，并可同时显示出 Ca2+ 拮抗作用和肾上腺素能 betareceptor
• US4727082A
  申请人：——

  公开号：US4727082A

  公开（公告）日：1988-02-23
• Dihydropyridine compounds and pharmaceutical compositions containing them
  申请人：Yamanouchi Pharmaceutical Co., Ltd.

  公开号：US04727082A1

  公开（公告）日：1988-02-23

  A dihydropyridine compound of the following general formula (I) or a salt thereof: ##STR1## wherein R.sup.1 and R.sup.2, which are the same or different, each represents a C.sub.1 to C.sub.10 alkyl group, a lower alkyl group which is interrupted by oxygen atom(s), or a lower alkyl group substituted by C.sub.3 to C.sub.6 alicyclic group(s); R.sup.3 and R.sup.4, which are the same or different, each represents a lower alkyl group; R.sup.5 and R.sup.6, which are the same or different, each represents a hydrogen atom, a nitro group, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a lower alkylsulfonyl group, or a lower alkylsulfinyl group; R.sup.7 and R.sup.8, which are the same or different, each represents a hydrogen atom, a halogen atom, a cyano group, a lower alkoxy group, or a lower alkanoylamino group, or R.sup.7 may combine with R.sup.8 to form a naphthyl group together with the adjacent phenyl group; A represents a single bond, a vinylene group (--CH.dbd.CH--), or a ethynylene group (--C.dbd.C--); B represents a single bond or --CH.sub. 2 O--; and m and n, which are the same or different, each represents 0 or an integer of 1 to 5. The compounds are useful for the treatment of various cardiovascular disorders, since they possess both Ca.sup.2+ -antagonistic and adrenergic beta-receptor blocking activities.

  以下一般式（I）的二氢吡啶化合物或其盐：##STR1##其中R.sup.1和R.sup.2，相同或不同，每个代表C.sub.1到C.sub.10烷基，被氧原子中断的较低烷基，或被C.sub.3到C.sub.6脂环烷基取代的较低烷基；R.sup.3和R.sup.4，相同或不同，每个代表较低烷基；R.sup.5和R.sup.6，相同或不同，每个代表氢原子，硝基团，卤素原子，较低烷基，较低烷氧基，较低烷硫基，较低烷基磺酰基或较低烷基亚磺酰基；R.sup.7和R.sup.8，相同或不同，每个代表氢原子，卤素原子，氰基，较低烷氧基或较低烷酰胺基，或R.sup.7可以与R.sup.8结合形成萘基连同相邻苯基；A代表单键，乙烯基（--CH.dbd.CH--）或乙炔基（--C.dbd.C--）；B代表单键或--CH.sub.2O--；m和n，相同或不同，每个代表0或1到5的整数。这些化合物对于治疗各种心血管疾病很有用，因为它们具有Ca.sup.2+ -拮抗和肾上腺素β受体阻滞活性。