1-(1-cyclohexenyl)-1-<(diphenylphosphinyl)imino>ethane | 118922-08-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(1-cyclohexenyl)-1-<(diphenylphosphinyl)imino>ethane
• 英文别名: (E)-1-(cyclohexen-1-yl)-N-diphenylphosphorylethanimine
• CAS: 118922-08-0
• 化学式: C₂₀H₂₂NOP
• 分子量: 323.375
• InChiKey: LDDRVRLEKDBINZ-HEHNFIMWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  29.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(1-cyclohexenyl)-1-<(diphenylphosphinyl)imino>ethane 、 乙烯基乙醚 以 二氯甲烷 为溶剂， 反应 135.0h， 以75%的产率得到(3S^*,4aR^*)-3-ethoxy-1-methyl-2-(diphenylphosphinyl)-2,3,4,4a,5,6,7,8-octahydroisoquinoline
  参考文献：
  名称：

  A general solution to implementing the 4.pi. participation of 1-aza-1,3-butadienes in Diels-Alder reactions: inverse electron demand Diels-Alder reactions of .alpha..beta.-unsaturated N-benzenesulfonyl imines

  摘要：

  DOI：

  10.1021/ja00186a067

文献信息

• Boger, Dale L.; Corbett, Wendy L.; Curran, Timothy T., Journal of the American Chemical Society, 1991, vol. 113, # 5, p. 1713 - 1729
  作者：Boger, Dale L.、Corbett, Wendy L.、Curran, Timothy T.、Kasper

  DOI：——

  日期：——
• General and practical catalytic enantioselective Strecker reaction of ketoimines: significant improvement through catalyst tuning by protic additives
  作者：Nobuki Kato、Masato Suzuki、Motomu Kanai、Masakatsu Shibasaki

  DOI：10.1016/j.tetlet.2004.02.082

  日期：2004.4

  Significant improvement in enantioselectivity and catalyst activity was achieved for the catalytic enantio selective Strecker reaction. Using a catalyst (1-2.5 mol%) prepared from Gd((OPr)-Pr-i)(3) and D-glucose derived ligand 1, and in the presence of 2,6-dimethylphenol as an additive, high enantioselectivity was obtained from a wide range of ketoimines, including heteroaromatic and cyclic ketoimines. The new method was applied to an efficient catalytic asymmetric synthesis of sorbinil, a therapeutic agent for diabetic complications. (C) 2004 Elsevier Ltd. All rights reserved.
• A general solution to implementing the 4.pi. participation of 1-aza-1,3-butadienes in Diels-Alder reactions: inverse electron demand Diels-Alder reactions of .alpha..beta.-unsaturated N-benzenesulfonyl imines
  作者：Dale L. Boger、Annette M. Kasper

  DOI：10.1021/ja00186a067

  日期：1989.2