N,N,N',N'-四乙基丁-2-炔-1,4-二胺 | 105-18-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N,N,N',N'-四乙基丁-2-炔-1,4-二胺
• 中文别名: N,N,N',N'-四乙基-2-丁炔-1,4-二胺
• 英文名称: N,N,N',N'-Tetraethyl-1,4-diaminobut-2-yne
• 英文别名: 1,4-bis(diethylamino)-2-butyne；tetra-N-ethyl-but-2-ynediyldiamine；Tetra-N-aethyl-but-2-indiyldiamin；N,N,N',N'-tetraethyl-2-butyne-1,4-diamine；N,N,N',N'-tetraethylbut-2-ynylenediamine；1,4-Bis-(diaethylamino)-butin-(2)；2-Butyne-1,4-diamine, N,N,N',N'-tetraethyl-；N,N,N',N'-tetraethylbut-2-yne-1,4-diamine
• CAS: 105-18-0
• 化学式: C₁₂H₂₄N₂
• mdl: MFCD00015118
• 分子量: 196.336
• InChiKey: ZSHOGSSMVWJOGA-UHFFFAOYSA-N

物化性质

• 沸点：
  323.24°C (rough estimate)
• 密度：
  0.8742 (rough estimate)
• 稳定性/保质期：
  可燃，受热会产生有毒的氮氧化物烟雾。

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2921290000
• 储存条件：
  库房应保持通风、低温和干燥，并与食品原料分开存放。

制备方法与用途

类别：有毒物品

毒性分级：高毒

急性毒性：静脉-小鼠 LD50: 56 毫克/公斤

可燃性危险特性：可燃；受热会产生有毒氮氧化物烟雾

储运特性：应存放在库房内，并保持通风、低温和干燥的环境；与食品原料分开存放

灭火剂：干粉、泡沫、沙土、二氧化碳或雾状水

反应信息

• 作为反应物：
  描述：

  N,N,N',N'-四乙基丁-2-炔-1,4-二胺 在 CrMCM-41 作用下， 生成 tetra-N-ethyl-trans,trans-buta-1,3-dienediyldiamine
  参考文献：
  名称：

  US2617827

  摘要：

  公开号：
• 作为产物：
  描述：

  二乙胺 、 1,4-二氯-2-丁炔 反应 2.0h， 以72%的产率得到N,N,N',N'-四乙基丁-2-炔-1,4-二胺
  参考文献：
  名称：

  Fungicidal activity of three putrescine analogues

  摘要：

  AbstractThe synthetic putrescine analogues (E)‐N,N,N′,N′‐tetraethyl‐l,4‐diaminobut‐2‐ene(E‐TED), the (Z)‐isomer (Z‐TED) and (E)‐N,N‐dimethyl‐1,4‐diaminobut‐2‐ene(E‐DMD) were prepared as their salts, and controlled five important crop pathogens (Erysiphe graminis DC f.sp. hordei Marchal, Uromyces viciae‐fabae (Pers.) Schroet, Botrytis fabae Sardina, Podosphaera leucotricha (Ell. & Ev.) Salm. and Phytophthora infestans (Mont.) De Bary). E‐TED was also effective in vitro, with growth of P. infestans and Pyrenophora avenae Ito & Kuribay completely inhibited at 1800 and 360 mg litre−1 respectively. When P. avence was grown in the presence of 180 mg E‐TED litre−1, there were significant reducuons in putrescine and spermidine concentrations (58% and 35% respectively). An apparent increase in ornithine decarboxylase activity and a decrease in S‐adenosylmethionine decarboxylase activity in P. avenae exposed to E‐TED at 36 mg litre−1 were not statistically significant. Diamine oxidase activity remained unchanged in fungal tissue exposed to E‐TED.

  DOI：

  10.1002/ps.2780410112

文献信息

• Acetylenic derivatives of metal carbonyls I. Substitution reactions of CO2(CO)6C2RR′ complexes
  作者：G. Cetini、O. Gambino、R. Rossetti、E. Sappa

  DOI：10.1016/s0022-328x(00)84714-2

  日期：1967.4

  In this work the substitution reactions were studied, of one acetylenic derivative, by another, in the complexes Co2(CO)6C2RR′ in which R and R′CF3, COOCH3, C6H5, CH2Cl, CH3, CH2N(C2H5)2 and H.

  在这项工作中的取代反应进行了研究，一个炔属衍生物的，通过另一个，在钴络合物2（CO）6 c ^ 2 RR'，其中R和R'CF 3，COOCH 3，C 6 H ^ 5，CH 2 Cl，CH 3，CH 2 N（C 2 H 5）2和H。
• Regio-and stereo-specific reduction of conjugated and non-conjugated triple bonds by activated zinc powder
  作者：Marc H. P. J. Aerssens、Lambert Brandsma

  DOI：10.1039/c39840000735

  日期：——

  Regio-as well as stereo-specific reductions of a wide variety of acetylenic derivatives have been carried out in absolute ethanol with zinc powder activated with 1,2-dibromoethane, and with zinc powder activated successively with dibromoethane and copper(I) bromide, the first reagent less powerful and more selective than the second one.

  在无水乙醇中，用1,2-二溴乙烷活化的锌粉，以及依次用二溴乙烷和溴化铜（I）活化的锌粉，进行了多种炔属衍生物的区域还原和立体特异性还原。与第二种试剂相比，第一种试剂的功能更弱，选择性更高。
• A Versatile Synthetic Method for Preparing 1,2,3,5-Tetrasubstituted Pyrroles Using Isothiocyanates and 2-Alkynyl Ethers or 2-Alkynylamines as Building Units
  作者：Lambert Brandsma、Nina A. Nedolya、Boris A. Trofimov

  DOI：10.1002/(sici)1099-0690(199910)1999:10<2663::aid-ejoc2663>3.0.co;2-c

  日期：1999.10

  A fundamentally new approach for the construction of pyrrole rings is exemplified by highly efficient one-pot syntheses of 1,2,3,5-tetrasubstituted pyrroles starting from alkyl isothiocyanates and 2-alkynylamines or 2-alkynyl ethers.

  从烷基异硫氰酸酯和2-炔基胺或2-炔基醚开始的高效一锅合成1,2,3,5-四取代的吡咯，举例说明了一种构建吡咯环的根本新方法。
• Novel benzothiazepine and bensothiepine compounds
  申请人：Sasahara Takehiko

  公开号：US20070190041A1

  公开（公告）日：2007-08-16

  A pharmaceutical useful as a therapeutic agent and a preventive agent for hyperlipemia, and a pharmaceutical useful as a therapeutic agent and a preventive agent for hepatic disorders associated with cholestasis, particularly, primary biliary cirrhosis and primary sclerosing cholangitis, and a pharmaceutical useful as a therapeutic agent and a preventive agent for obesity, fatty liver and steatohepatitis are provided. A benzothiazepine or benzothiepine compound represented by the following formula (1A) having a thioamide bond and a quaternary ammonium substitutent:

  提供了一种药物，可用作治疗和预防高脂血症的治疗剂和预防剂，以及一种药物，可用作治疗和预防与胆汁淤积有关的肝脏疾病，特别是原发性胆汁性肝硬化和原发性硬化性胆管炎的治疗剂和预防剂，以及一种药物，可用作治疗和预防肥胖症、脂肪肝和脂肪性肝炎的治疗剂和预防剂。化合物的苯并噻吩或苯并噻环代表如下式（1A），具有硫酰胺键和季铵取代基：
• Novel quaternary ammonium compounds
  申请人：Sasahara Takehiko

  公开号：US20070203115A1

  公开（公告）日：2007-08-30

  A method for inhibiting ileal bile acid transporter activity in a subject, comprising administering to said subject an effective amount of a compound represented by formula (1):

  一种抑制回肠胆汁酸转运蛋白活性的方法，包括向该受试者施用一种由式（1）所代表的化合物的有效量：