1-nitroanthraquinone | 36925-31-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 1-nitroanthraquinone
• 英文别名: 1-Nitroanthracene；1-nitro-anthracene；1-Nitro-anthracen；nitroanthracene；Anthracene, nitro-
• CAS: 36925-31-2
• 化学式: C₁₄H₉NO₂
• 分子量: 223.231
• InChiKey: JBDYKGMNMDIHFL-UHFFFAOYSA-N

物化性质

• 熔点：
  146 °C
• 沸点：
  413.3±14.0 °C(Predicted)
• 密度：
  1.316±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-nitroanthraquinone 在 盐酸 、 tin 作用下， 生成 1-氨基蒽
  参考文献：
  名称：

  Battegay; Boehler, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1936, vol. 203, p. 333

  摘要：

  DOI：
• 作为产物：
  描述：

  蒽 在 copper nitrate trihydrate 作用下， 反应 1.0h， 以93%的产率得到1-nitroanthraquinone
  参考文献：
  名称：

  机械力作用下实现硝酸盐硝化芳香族化合物 的方法

  摘要：

  本发明公开了机械力作用下实现硝酸盐硝化芳香族化合物的方法。本发明提供的一种芳香族硝基化合物的制备方法，包括如下步骤：在机械力作用下，芳香族化合物与金属硝酸盐或其水合物经硝化反应，得到所述芳香族硝基化合物；所述机械力为机械提供的能引起物质物理和/或化学性质变化的外力。所述机械力可为压缩、剪切、冲击、摩擦、拉伸、弯曲和振动中的任一种。本发明具有如下优点：无需使用任何溶剂，避免了废液产生；不需使用酸性物质，反应完成后处理简单，对设备无任何损伤；极高的转化率和选择性，可以应用于硝化常规芳香族化合物。

  公开号：

  CN108409575B

文献信息

• Sustainable chemical process for reduction of nitro compounds (R-NO2) or nitroso compounds (R-NO) containing sulphonic or carboxylic group into corresponding amino compounds (R-NH2) with inherent recycle of all acidic streams generated in synthesis
  申请人：Padia Bhadresh K.

  公开号：US20120203031A1

  公开（公告）日：2012-08-09

  The process of the present invention creates a sustainable and closed water loop allowing inherent recycles of all liquid streams generated in the process. The liquid streams generated during the process of the invention are inherently recycled completely, making the process of the present invention a zero liquid discharge process which is environmentally friendly and sustainable. This invention further relates to a sustainable chemical process of reduction of R—NO 2 or R—NO into corresponding R—NH 2 that produces environmentally friendly R—NH 2 in good yields and selectivity with large of mother liquor recycle. The process has a wide scope in that it can be applied to a number of molecules.

  本发明的过程创建了一个可持续和封闭的水循环，允许在过程中生成的所有液体流的固有循环利用。在本发明的过程中生成的液体流被固有地完全回收利用，使得本发明的过程成为一种零液体排放的环保和可持续过程。该发明进一步涉及一种可持续的化学过程，将R—NO2或R—NO还原为相应的R—NH2，产生环保的R—NH2，产率高，选择性好，具有大量母液回收。该过程的范围广泛，可以应用于许多分子。
• [EN] SUSTAINABLE CHEMICAL PROCESS FOR REDUCTION OF NITRO COMPOUNDS (R-NO2) OR NITROSO COMPOUNDS (R-NO) CONTAINING SULPHONIC OR CARBOXYLIC GROUP INTO CORRESPONDING AMINO COMPOUNDS (R-NH2) WITH INHERENT RECYCLE OF ALL ACIDIC STREAMS GENERATED IN SYNTHESIS<br/>[FR] PROCÉDÉ CHIMIQUE ÉCOLOGIQUE POUR LA RÉDUCTION DE COMPOSÉS NITRO (R-NO2) OU DE COMPOSÉS NITROSO (R-NO) CONTENANT UN GROUPE SULFONIQUE OU CARBOXYLIQUE EN COMPOSÉS AMINO CORRESPONDANTS (R-NH2) AVEC UN RECYCLAGE INHÉRENT DE TOUS LES COURANTS ACIDES PRODU
  申请人：PADIA BHADRESH K

  公开号：WO2011048535A1

  公开（公告）日：2011-04-28

  The process of the present invention creates a sustainable and closed water loop allowing inherent recycles of all liquid streams generated in the process. The liquid streams generated during the process of the invention are inherently recycled completely, making the process of the present invention a zero liquid discharge process which is environmentally friendly and sustainable. This invention further relates to a sustainable chemical process of reduction of R- NO2 or R-NO into corresponding R-NH2 that produces environmentally friendly R-NH2 in good yields and selectivity with large of mother liquor recycle. The process has a wide scope in that it can be applied to a number of molecules.

  本发明的过程创建了一个可持续和闭合的水循环，允许在过程中产生的所有液体流的固有循环。在本发明的过程中产生的液体流被固有地完全回收利用，使得本发明的过程成为一种零液体排放的环保和可持续的过程。该发明还涉及一种可持续的化学过程，用于将R-NO2或R-NO还原为相应的R-NH2，产生具有良好产率和选择性的环保R-NH2，并具有大量母液回收。该过程具有广泛的适用范围，可应用于多种分子。
• [EN] ANTHRACENE BASED COMPOUNDS AND THEIR USES<br/>[FR] COMPOSÉS À BASE D'ANTHRACÈNE ET LEURS UTILISATIONS
  申请人：UNIV OF HERTFORDSHIRE HIGHER EDUCATION CORP

  公开号：WO2016181120A1

  公开（公告）日：2016-11-17

  The present invention relates to compounds of the general formula (A) and their applicability for use in the treatment or prophylaxis of a disease, in particular for use as in treatment of cancer, in particular for use as in treatment of pancreatic cancer, in particular as inhibitors of S100P/RAGE interaction in pancreatic cancer. In summary herein are presented a group of compounds for use as in treatment of cancer, in particular as inhibitors of S100P/RAGE interaction in pancreatic cancer. The compounds have general formula (A): (A) or may be a pharmaceutically acceptable salt, solvate, hydrate, polymorph, prodrug, codrug, cocrystal, tautomer, racemate, stereoisomer or mixture thereof. X is independently NO2 or H; and Y is independently H or a side group. The compounds all have a lower fused ring system based on nitroanthracene or anthracene. The group Y attached to the N of the succinimide group varies between the compounds. For example, Y may be substituted or non-substituted benzene ring. Alternatively, in some examples Y is a heteroaromatic system. It has been discovered from studies by the inventors that the compounds described will inhibit S100P/RAGE interaction and are therefore useful for treating pancreatic cancer.

  本发明涉及一般式（A）的化合物及其在治疗或预防疾病方面的适用性，特别是在癌症治疗中的应用，特别是在胰腺癌治疗中的应用，特别是作为胰腺癌中S100P/RAGE相互作用的抑制剂。总之，这里介绍了一组化合物，用于癌症治疗，特别是作为胰腺癌中S100P/RAGE相互作用的抑制剂。这些化合物具有一般式（A）：（A）或者可能是药用可接受的盐、溶剂化合物、水合物、多晶形、前药、共药、共晶、互变异构体、拉氏体异构体或其混合物。X独立地是NO2或H；Y独立地是H或侧基。所有这些化合物都基于硝基蒽或蒽的较低融合环系统。连接到琥酰亚胺基团的N的Y基团在这些化合物之间变化。例如，Y可能是取代或非取代的苯环。另外，在某些例子中，Y是一个杂环芳香系统。发明者的研究表明，所描述的化合物将抑制S100P/RAGE相互作用，因此对治疗胰腺癌是有用的。
• Method of manufacturing aromatic urethane
  申请人：NKK CORPORATION

  公开号：EP0310907A1

  公开（公告）日：1989-04-12

  This invention is a method of manufacturing aro­matic urethane including an aromatic urea production step of reacting an aromatic primary amine, an aromatic nitro-compound, and carbon monoxide with one another, using a catalyst mainly consisting of a compound con­taining a platinum group metal, and using a compound having a coordination ability to the catalyst as at least part of a solvent, thereby producing N,N′-di-­substituted urea, and separating and isolating the produced N,N′-di-substituted urea from the reaction solution, and further including a step of reacting the N,N′-di-substituted urea obtained in the urea produc­tion step with an organic compound containing a hydroxyl group to produce the aromatic primary amine and aromatic urethane, and separating the aromatic primary amine to produce aromatic urethane.

  这项发明是一种制造芳香族脲的方法，包括芳香族脲生产步骤，其中反应芳香族主要胺、芳香族硝基化合物和一氧化碳，使用主要由含有铂族金属的化合物组成的催化剂，并且使用具有对催化剂的配位能力的化合物作为至少部分溶剂，从而产生N,N'-二取代脲，并将生成的N,N'-二取代脲从反应溶液中分离和分离，并进一步包括将在脲生产步骤中获得的N,N'-二取代脲与含有羟基的有机化合物反应以产生芳香族主要胺和芳香族脲的步骤，并分离芳香族主要胺以产生芳香族脲。
• Resin useful for resist, resist composition and pattern forming process using the same
  申请人：KABUSHIKI KAISHA TOSHIBA

  公开号：US20020098441A1

  公开（公告）日：2002-07-25

  According to the present invention, a resist resin having in its structure a specific bridged-bond-containing aliphatic ring, and a resist composition comprising the same are provided. By using this resist composition, a resist pattern excellent in both transparency against short-wavelength light and dry-etching resistance can be formed by alkali development with high resolution.

  根据本发明，提供了一种在其结构中具有特定桥式键含有的脂环的抗蚀树脂，以及包括该树脂的抗蚀组合物。通过使用这种抗蚀组合物，可以通过高分辨率的碱性显影形成对短波长光具有优异透明度和干法刻蚀抗性的抗蚀图案。