Several 2,4-dinitro-N-acylanilines were regioselectively reduced at the C-2 position by baker's yeast in slightly basic media (pH = 7.5) to afford 2-amino-4-nitroacylanilines, which were then cyclized under acidic conditions to the corresponding 2-substituted-6-nitrobenzimidazoles. The benzimidazoles thus obtained can be employed as precursors for bioactive derivatives.
几种 2,4-二硝基-N-酰基
苯胺在微碱性介质(pH = 7.5)中被面包酵母在 C-2 位置区域选择性还原,得到 2-
氨基-4-硝基酰基
苯胺,然后在酸性条件下环化为相应的 2-取代-
6-硝基苯并咪唑。由此获得的
苯并咪唑可用作
生物活性衍
生物的前体。