N-(4-Methylbenzyl)-4-nitrobenzenesulfonamide | 5523-88-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-Methylbenzyl)-4-nitrobenzenesulfonamide
• 英文别名: N-[(4-methylphenyl)methyl]-4-nitrobenzenesulfonamide
• CAS: 5523-88-6
• 化学式: C₁₄H₁₄N₂O₄S
• mdl: MFCD01213765
• 分子量: 306.342
• InChiKey: AYMQSUBRUMQHCD-UHFFFAOYSA-N

物化性质

• 溶解度：
  1.8 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  100
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-(4-Methylbenzyl)-4-nitrobenzenesulfonamide 在 盐酸 、 tin 作用下， 以 乙醇 、 水 为溶剂， 以100%的产率得到4-amino-N-(4-methylbenzyl)benzenesulfonamide
  参考文献：
  名称：

  Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists

  摘要：

  To date, many known G protein-coupled receptor 55 (GPR55) ligands are those identified among the cannabinoids. In order to further study the function of GPR55, new potent and selective ligands are needed. In this study, we utilized the screening results from PubChem bioassay AID 1961 which reports the results of Image-based HIS for Selective Agonists of GPR55. Three compounds, CID1792579, CID1252842 and CID1011163, were further evaluated and used as a starting point to create a series of nanomolar potency GPR55 agonists with N-(4-sulfamoylphenyl)thiourea scaffold. The GPR55 activity of the compounds were screened by using a commercial beta-arrestin PathHunter assay and the potential compounds were further evaluated by using a recombinant HEK cell line exhibiting GPR55-mediated effects on calcium signalling. The designed compounds were not active when tested against various endocannabinoid targets (CB1R, CB2R, FAAH, MGL, ABHD6 and ABHD12), indicating compounds' selectivity for the GPR55. Finally, structure activity relationships of these compounds were explored. (C) 2015 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2015.10.050
• 作为产物：
  描述：

  对硝基苯磺酰氯 、 4-甲基苄胺 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以64%的产率得到N-(4-Methylbenzyl)-4-nitrobenzenesulfonamide
  参考文献：
  名称：

  Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists

  摘要：

  To date, many known G protein-coupled receptor 55 (GPR55) ligands are those identified among the cannabinoids. In order to further study the function of GPR55, new potent and selective ligands are needed. In this study, we utilized the screening results from PubChem bioassay AID 1961 which reports the results of Image-based HIS for Selective Agonists of GPR55. Three compounds, CID1792579, CID1252842 and CID1011163, were further evaluated and used as a starting point to create a series of nanomolar potency GPR55 agonists with N-(4-sulfamoylphenyl)thiourea scaffold. The GPR55 activity of the compounds were screened by using a commercial beta-arrestin PathHunter assay and the potential compounds were further evaluated by using a recombinant HEK cell line exhibiting GPR55-mediated effects on calcium signalling. The designed compounds were not active when tested against various endocannabinoid targets (CB1R, CB2R, FAAH, MGL, ABHD6 and ABHD12), indicating compounds' selectivity for the GPR55. Finally, structure activity relationships of these compounds were explored. (C) 2015 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2015.10.050

文献信息

• Competitive Reaction Pathways in the Nucleophilic Substitution Reactions of Aryl Benzenesulfonates with Benzylamines in Acetonitrile
  作者：Jin Heui Choi、Byung Choon Lee、Hai Whang Lee、Ikchoon Lee

  DOI：10.1021/jo0161835

  日期：2002.2.1

  The reactions of aryl benzenesulfonates (YC6H4SO2OC6H4Z) with benzylamines (XC6H4CH2NH2) in acetonitrile at 65.0 degrees C have been studied. The reactions proceed competitively by S-O (kS-O) and C-O (kC-O) bond scission, but the former provides the major reaction pathway. On the basis of analyses of the Hammett and Brönsted coefficients together with the cross-interaction constants rho(XY), rho(YZ)

  研究了芳基苯磺酸盐（YC6H4SO2OC6H4Z）与苄胺（XC6H4CH2NH2）在乙腈中于65.0摄氏度下的反应。反应通过SO（kS-O）和CO（kC-O）键分裂而竞争地进行，但前者提供了主要的反应途径。在分析Hammett和Brönsted系数以及交叉相互作用常数rho（XY），rho（YZ）和rho（XZ）的基础上，提出了通过限速形成SO键裂解的逐步机理三角-双锥体五元（TBP-5C）中间体，而CO键断裂则是通过限速从Meisenheimer型络合物中排出磺酸根阴离子（YC6H4SO3-）来进行的。
• Base‐Promoted Michael Addition/Smiles Rearrangement/ <i>N</i> ‐Arylation Cascade: One‐Step Synthesis of 1,2,3‐Trisubstituted 4‐Quinolones from Ynones and Sulfonamides
  作者：Jing Liu、Dan Ba、Weiwei Lv、Yanhui Chen、Zemin Zhao、Guolin Cheng

  DOI：10.1002/adsc.201900960

  日期：2020.1.7

  synthesize 1,2,3‐trisubstituted 4‐quinolones from readily available ynones and sulfonamides was developed. The construction of one C−C bond and two C−N bonds via cleavage of one N−S, one C−S, and one C−X (X=F, Cl, Br, O) bond is achieved under transition‐metal‐free conditions in one step. This transformation generates 1 equiv. of sulfur dioxide and 1 equiv. of hydrogen halide as the byproducts. The broad substrate

  已开发了一种通用，实用且环保的方案，可以从容易获得的炔酮和磺酰胺中合成1,2,3-三取代的4-喹诺酮。在过渡金属的作用下，通过裂解一个N-S，一个C-S和一个C-X（X = F，Cl，Br，O）键，可以构建一个C-C键和两个C-N键。一步就能达到无条件。此变换生成1个当量。二氧化硫和1当量 卤化氢作为副产物。1,2,3-三取代的4-喹诺酮类化合物的52个实例证明了广泛的底物范围和官能团耐受性。初步的机理研究支持顺序的迈克尔加成/微笑重排/ N芳基化反应途径。
• Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists
  作者：Sari Yrjölä、Teija Parkkari、Dina Navia-Paldanius、Tuomo Laitinen、Agnieszka A. Kaczor、Tarja Kokkola、Frank Adusei-Mensah、Juha R. Savinainen、Jarmo T. Laitinen、Antti Poso、Amy Alexander、June Penman、Lisa Stott、Marie Anskat、Andrew J. Irving、Tapio J. Nevalainen

  DOI：10.1016/j.ejmech.2015.10.050

  日期：2016.1

  To date, many known G protein-coupled receptor 55 (GPR55) ligands are those identified among the cannabinoids. In order to further study the function of GPR55, new potent and selective ligands are needed. In this study, we utilized the screening results from PubChem bioassay AID 1961 which reports the results of Image-based HIS for Selective Agonists of GPR55. Three compounds, CID1792579, CID1252842 and CID1011163, were further evaluated and used as a starting point to create a series of nanomolar potency GPR55 agonists with N-(4-sulfamoylphenyl)thiourea scaffold. The GPR55 activity of the compounds were screened by using a commercial beta-arrestin PathHunter assay and the potential compounds were further evaluated by using a recombinant HEK cell line exhibiting GPR55-mediated effects on calcium signalling. The designed compounds were not active when tested against various endocannabinoid targets (CB1R, CB2R, FAAH, MGL, ABHD6 and ABHD12), indicating compounds' selectivity for the GPR55. Finally, structure activity relationships of these compounds were explored. (C) 2015 Elsevier Masson SAS. All rights reserved.