4-methyl-N-[(1S)-1-phenyl-2,3-dihydroinden-1-yl]benzenesulfonamide | 1246661-97-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methyl-N-[(1S)-1-phenyl-2,3-dihydroinden-1-yl]benzenesulfonamide
• CAS: 1246661-97-1
• 化学式: C₂₂H₂₁NO₂S
• 分子量: 363.48
• InChiKey: MOWFSXWLPWRKIO-QFIPXVFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯硼酸 在 potassium hydrogen difluoride 、 (RhCl(C₈H₈(C₆H₄CF₃)2))2 作用下， 以 1,4-二氧六环 、 甲醇 、 水 为溶剂， 反应 24.5h， 生成 4-methyl-N-[(1S)-1-phenyl-2,3-dihydroinden-1-yl]benzenesulfonamide
  参考文献：
  名称：

  Rhodium-Catalyzed Asymmetric Addition of Potassium Organotrifluoroborates toN-Sulfonyl Ketimines

  摘要：

  A rhodium-catalyzed asymmetric addition of readily available potassium organotrifluoroborates to both N-tosyl and N-nosyl ketimines has bean developed. High enantioselectivity has been achieved by using a chiral diene ligand, and the nosyl group of the addition products can be easily removed while retaining the enantiomeric purity.

  DOI：

  10.1021/ol200958q

文献信息

• Rhodium-Catalyzed Asymmetric Arylation of <i>N</i>-Tosyl Ketimines
  作者：Ryo Shintani、Momotaro Takeda、Takaoki Tsuji、Tamio Hayashi

  DOI：10.1021/ja106114q

  日期：2010.9.29

  A rhodium-catalyzed addition of sodium tetraarylborates to N-tosyl ketimines is described. Highly efficient asymmetric catalysis has been achieved by employing a chiral diene ligand, constructing chiral amine derivatives possessing alpha-tetrasubstituted carbon stereocenters with high enantioselectivity.
• Rhodium-Catalyzed Asymmetric Addition of Potassium Organotrifluoroborates to<i>N</i>-Sulfonyl Ketimines
  作者：Ryo Shintani、Momotaro Takeda、Ying-Teck Soh、Tomoaki Ito、Tamio Hayashi

  DOI：10.1021/ol200958q

  日期：2011.6.17

  A rhodium-catalyzed asymmetric addition of readily available potassium organotrifluoroborates to both N-tosyl and N-nosyl ketimines has bean developed. High enantioselectivity has been achieved by using a chiral diene ligand, and the nosyl group of the addition products can be easily removed while retaining the enantiomeric purity.