N-p-fluorobenzoyl-phenylhydroxylamine | 13664-14-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-p-fluorobenzoyl-phenylhydroxylamine
• 英文别名: 4-fluoro-N-hydroxy-N-phenylbenzamide
• CAS: 13664-14-7
• 化学式: C₁₃H₁₀FNO₂
• 分子量: 231.226
• InChiKey: PJGMEVOCPLFHTP-UHFFFAOYSA-N

物化性质

• 熔点：
  137 °C(Solv: benzene (71-43-2))
• 沸点：
  381.4±44.0 °C(Predicted)
• 密度：
  1.343±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-p-fluorobenzoyl-phenylhydroxylamine 在 盐酸 、 十六烷基三甲基氯化铵 作用下， 以 1,4-二氧六环 、 水 为溶剂， 生成 对氟苯甲酸
  参考文献：
  名称：

  Ghosh, Kallol K.; Roy, Supriya, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1997, vol. 36, # 4, p. 324 - 328

  摘要：

  DOI：
• 作为产物：
  描述：

  对氟苯甲酰氯 、 苯基羟胺 在 碳酸氢钠 作用下， 以 乙醚 为溶剂， 生成 N-p-fluorobenzoyl-phenylhydroxylamine
  参考文献：
  名称：

  Ghosh, Kallol K.; Roy, Supriya, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1997, vol. 36, # 4, p. 324 - 328

  摘要：

  DOI：

文献信息

• Benzaldehyde Lyase-Catalyzed Direct Amidation of Aldehydes with Nitroso Compounds
  作者：Peruze Ayhan、Ayhan S. Demir

  DOI：10.1002/adsc.201000735

  日期：2011.3.7

  furnishes N‐arylhydroxamic acids in high yields. Aromatic aldehydes and benzoins are converted into enamine‐carbanion‐like intermediates prior to their reaction with nitroso compounds. The kinetic resolution of rac‐2‐hydroxy‐1,2‐diphenylethanones furnished (S)‐benzoins and arylhydroxamic acids with high enantioselectivities and conversions.

  荧光假单胞菌的苯甲醛裂解酶催化芳香醛与亚硝基化合物的反应，并以高收率提供N-芳基异羟肟酸。芳香醛和安息香在与亚硝基化合物反应之前，先转化为烯胺-碳二阴离子类中间体。具有高对映选择性和转化率的rac -2-羟基1,2-二苯基乙酮提供的动力学拆分（S）-安息香和芳基异羟肟酸。
• Ghosh, Kallol K.; Ghosh, Sharmistha, Journal of the Indian Chemical Society, 1995, vol. 72, # 9, p. 603 - 608
  作者：Ghosh, Kallol K.、Ghosh, Sharmistha

  DOI：——

  日期：——
• Acid-Catalyzed Hydrolysis of N-Phenyl-4-substituted-benzohydroxamic Acids
  作者：Kallol K. Ghosh、Sharmistha Ghosh

  DOI：10.1021/jo00085a028

  日期：1994.3

  Acidity rate profiles have been established for the hydrolysis of some N-phenyl-4-substituted-benzohydroxamic acids 4-XC6H4(C=O)N(OH)C6H5 (X = H, CH3, OCH3, NO2, Cl, F) in sulfuric acid solutions in 20/80 (v/v) dioxane-water medium. Analysis of the data by the Cox-Yates excess acidity method and substitutent, temperature, and solvent isotope effects are all compatible with a changeover from an A-2 mechanism at low acidities to a predominantly A-1 mechanism at high acidities.
• Ghosh, Kallol K.; Krishnani, Kishor K., Journal of Chemical Research, Miniprint, 1993, # 12, p. 3143 - 3154
  作者：Ghosh, Kallol K.、Krishnani, Kishor K.

  DOI：——

  日期：——
• Solid-phase extraction of plutonium(IV) an americium(III) using N-benzoylphenylhydroxylamine and its derivatives
  作者：O. M. Petrukhin、B. Ya. Spivakov、V. P. Morgalyuk、G. I. Malofeeva、E. V. Kuzovkina、A. P. Novikov

  DOI：10.1134/s0036023611110192

  日期：2011.11

  The recovery and separation of plutonium(IV) and americium(III) by solid-phase extraction (SPE) on alkylated silica gel S16 modified with N-benzoylphenylhydroxylamine (BPHA) and with its derivatives was studied. BPHA was modified by introducing into the p-position of the phenyl ring of electronactive substituents that differ in their hydrophobicity: CH(3), Ph, Cl, F, and NO(2). The SPE of plutonium(IV) and americium(III) was studied in the range of acidities from pH 8 to 1 M HNO(3). The recovery and separation of these elements was shown to depend on the nature of the substituent, aqueous acidity, and the preparation of S16 to SPE experiments.