2-((3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-pentadecafluorononan-2-ylidene)amino)ethan-1-ol | 1359037-35-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-((3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-pentadecafluorononan-2-ylidene)amino)ethan-1-ol
• CAS: 1359037-35-6
• 化学式: C₁₁H₈F₁₅NO
• 分子量: 455.167
• InChiKey: PRBDNTLIQYTPQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.81
• 重原子数：
  28.0
• 可旋转键数：
  8.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  32.59
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  2-((3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-pentadecafluorononan-2-ylidene)amino)ethan-1-ol 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 50.0 ℃ 、8.0 MPa 条件下， 反应 16.0h， 以78%的产率得到2-((3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-pentadecafluorononan-2-yl)amino)ethan-1-ol
  参考文献：
  名称：

  Synthesis and self-assembling behavior of F-amphiphilic functionalized amines

  摘要：

  A simple route to fluoroalkylated functionalized secondary amines is proposed by the treatment of 2-perfluoroalkylprop-2-enoic acids with various primary amines. Two of these compounds were obtained from oxyethylenic diamine and present an amphiphilic structure.These compounds exhibit an excellent surface activity since they are lowering the surface tension to 18-20 mN/m and this, at very low concentrations (around 10(-5) M). DLS measurements and TEM studies show an original behavior of the monocatenar fluorinated surfactants 5n and 5o, which are able to spontaneously self-assembles into vesicles, and therefore it makes them suitable candidates as carriers in drug or gene delivery systems. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2011.03.019
• 作为产物：
  描述：

  acide 2-perfluorooctylethanoieque 在 sodium hydroxide 作用下， 以 四氢呋喃 、 水 、 甲苯 为溶剂， 反应 24.0h， 生成 2-((3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-pentadecafluorononan-2-ylidene)amino)ethan-1-ol
  参考文献：
  名称：

  Synthesis and self-assembling behavior of F-amphiphilic functionalized amines

  摘要：

  A simple route to fluoroalkylated functionalized secondary amines is proposed by the treatment of 2-perfluoroalkylprop-2-enoic acids with various primary amines. Two of these compounds were obtained from oxyethylenic diamine and present an amphiphilic structure.These compounds exhibit an excellent surface activity since they are lowering the surface tension to 18-20 mN/m and this, at very low concentrations (around 10(-5) M). DLS measurements and TEM studies show an original behavior of the monocatenar fluorinated surfactants 5n and 5o, which are able to spontaneously self-assembles into vesicles, and therefore it makes them suitable candidates as carriers in drug or gene delivery systems. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2011.03.019