N-phenyl-N'-propionyl-urea | 91146-49-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-phenyl-N'-propionyl-urea
• 英文别名: N-Phenyl-N'-propionyl-harnstoff；N-propionyl-N'-phenylurea；N-phenyl-N'-propionylurea；N-(phenylcarbamoyl)propanamide
• CAS: 91146-49-5
• 化学式: C₁₀H₁₂N₂O₂
• 分子量: 192.217
• InChiKey: AOWYFOXIGANBGA-UHFFFAOYSA-N

物化性质

• 密度：
  1.190±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-phenyl-N'-propionyl-thiourea 在 silver nitrate 作用下， 生成 N-phenyl-N'-propionyl-urea
  参考文献：
  名称：

  Ten Ways to Reduce Detention Population

  摘要：

  ABSTRACT“Juvenile detention is regularly overlooked, maligned, and misunderstood. Its embattled condition is best described as severely abused and neglected. It is underfunded, understaffed, crowded and largely ignored.”1“Detention caseloads increased 38 percent between 1987 and 1996. The increase in the number of delinquency cases handled by the courts has driven the growth in the number of juveniles in the detention system. In 1987, 1.2 million delinquency cases were disposed of in juvenile courts. By 1996, this number had risen 49 percent, to almost 1.8 million. This increase in the volume of juveniles in the justice system resulted in a 38 percent increase in the number of delinquency cases that involved the use of detention. The number of juvenile delinquency cases detained in 1996 was 89,000 more than in 1987. This has resulted in increased demand for juvenile detention bed space across the country.”2“Changes in statutes allowing more detainable offenses have significantly increased the number of youths admitted to regional detention centers.”3“Although minority youth constituted about 32 percent of the youth population in the country in 1995, they represented 68 percent of the juvenile population in secure detention…4

  DOI：

  10.1111/j.1755-6988.2001.tb00036.x

文献信息

• In situ slow release of isocyanates: synthesis and organocatalytic application of N-acylureas
  作者：Atul K. Singh、Ruchi Chawla、Lal Dhar S. Yadav

  DOI：10.1016/j.tetlet.2013.07.045

  日期：2013.9

  A novel, efficient, and operationally simple one-pot synthesis of both, symmetrical and unsymmetrical N-acylureas from carboxamides and in situ generated isocyanates (from N,N-dibromo-p-toluenesulfonamide) in the presence of a mild base at rt is reported. The protocol avoids the tedious isolation and purification steps of hazardous isocyanates. The first application of these acylureas to the catalysis

  在室温下在弱碱存在下，由酰胺和原位生成的异氰酸酯（由N，N-二溴-对甲苯磺酰胺）合成对称，不对称的N-酰基脲的新颖，有效且操作简单的方法是报告。该协议避免了危险的异氰酸酯的繁琐分离和纯化步骤。还显示了这些酰脲在氢键催化中的首次应用。
• Pinner, Chemische Berichte, 1890, vol. 23, p. 2953
  作者：Pinner

  DOI：——

  日期：——
• Kuehn, Chemische Berichte, 1884, vol. 17, p. 2882
  作者：Kuehn

  DOI：——

  日期：——
• PHENYL ISOCYANATE CONVERSION PROCESS
  申请人：Dow Global Technologies LLC

  公开号：EP3921349A1

  公开（公告）日：2021-12-15
• US4072712A
  申请人：——

  公开号：US4072712A

  公开（公告）日：1978-02-07